Phosphorylation of WWTR1 (TAZ) by LATS1

Stable Identifier
R-HSA-2060328
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of WWTR1 (TAZ) by LATS1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Cytosolic phospho-LATS1, complexed with MOB1, catalyzes the phosphorylation of WWTR1 (TAZ) on serine residue 89. This activity of human LATS1 protein has not been demonstrated experimentally but is inferred from the activity of human paralogue LATS2 and of mouse homologue LATS1 (Varelas et al. 2010).
Literature References
PubMed ID Title Journal Year
20412773 The Hippo pathway regulates Wnt/beta-catenin signaling

Pawson, T, Wrana, JL, Gregorieff, A, Sakuma, R, Fellouse, FA, Attisano, L, Varelas, X, Song, S, McNeill, H, Hunziker, W, Miller, BW, Sopko, R

Dev Cell 2010
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-LATS1:p-MOB1 [cytosol]

Physical Entity
p-LATS1:p-MOB1 [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of WWTR1 (TAZ) by LATS1 (Bos taurus)
Phosphorylation of WWTR1 (TAZ) by LATS1 (Caenorhabditis elegans)
Phosphorylation of WWTR1 (TAZ) by LATS1 (Canis familiaris)
Phosphorylation of WWTR1 (TAZ) by LATS1 (Danio rerio)
Phosphorylation of WWTR1 (TAZ) by LATS1 (Gallus gallus)
Phosphorylation of WWTR1 (TAZ) by LATS1 (Mus musculus)
Phosphorylation of WWTR1 (TAZ) by LATS1 (Rattus norvegicus)
Phosphorylation of WWTR1 (TAZ) by LATS1 (Sus scrofa)
Phosphorylation of WWTR1 (TAZ) by LATS1 (Xenopus tropicalis)
Authored
D'Eustachio, P  (2012-02-03)
Reviewed
Sudol, M  (2012-02-03)
Created
D'Eustachio, P  (2012-01-16)
Cite Us!