Cytosolic phospho-LATS1, complexed with MOB1, catalyzes the phosphorylation of WWTR1 (TAZ) on serine residue 89. This activity of human LATS1 protein has not been demonstrated experimentally but is inferred from the activity of human paralogue LATS2 and of mouse homologue LATS1 (Varelas et al. 2010).
Pawson, T, Wrana, JL, Gregorieff, A, Sakuma, R, Fellouse, FA, Attisano, L, Varelas, X, Song, S, McNeill, H, Hunziker, W, Miller, BW, Sopko, R
protein serine/threonine kinase activity of p-LATS1:p-MOB1 [cytosol]
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