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ZFYVE9-1 [early endosome membrane]
Stable Identifier
R-HSA-206180
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
early endosome membrane
Synonyms
SARA, ZFYVE9 isoform 1
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by TGF-beta Receptor Complex in Cancer (Homo sapiens)
Loss of Function of SMAD2/3 in Cancer (Homo sapiens)
SMAD2/3 Phosphorylation Motif Mutants in Cancer (Homo sapiens)
Activated TGFBR1 cannot phosphorylate SMAD2 and SMAD3 Phosphorylation Motif Mutants (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 Phosphorylation Motif Mutants [early endosome membrane] (Homo sapiens)
ZFYVE9-1 [early endosome membrane] (Homo sapiens)
Loss of Function of TGFBR1 in Cancer (Homo sapiens)
TGFBR1 KD Mutants in Cancer (Homo sapiens)
An anchoring protein ZFYVE9 (SARA) does not recruit SMAD2/3 to TGFB1:TGFBR2:p-TGFBR1 KD Mutants (Homo sapiens)
ZFYVE9-1 [early endosome membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Activated type I receptor phosphorylates SMAD2/3 directly (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Homo sapiens)
ZFYVE9-1 [early endosome membrane] (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Homo sapiens)
ZFYVE9-1 [early endosome membrane] (Homo sapiens)
An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Homo sapiens)
ZFYVE9-1 [early endosome membrane] (Homo sapiens)
ZFYVE9-1 [early endosome membrane] (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
PP1 dephosphorylates TGFBR1 (Homo sapiens)
TGFB1:p-TGFBR:I-SMAD7:GADD34:PP1:ZFYVE9 [early endosome membrane] (Homo sapiens)
ZFYVE9-1 [early endosome membrane] (Homo sapiens)
ZFYVE9-1 [early endosome membrane] (Homo sapiens)
SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR (Homo sapiens)
TGFB1:p-TGFBR:I-SMAD7:GADD34:PP1:ZFYVE9 [early endosome membrane] (Homo sapiens)
ZFYVE9-1 [early endosome membrane] (Homo sapiens)
ZFYVE9-1 [early endosome membrane] (Homo sapiens)
Phosphorylated SMAD2/3 dissociates from TGFBR (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9 [early endosome membrane] (Homo sapiens)
ZFYVE9-1 [early endosome membrane] (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Homo sapiens)
ZFYVE9-1 [early endosome membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95405-1 ZFYVE9
Gene Names
ZFYVE9, MADHIP, SARA, SMADIP
Other Identifiers
11730983_a_at
11730984_a_at
11738130_a_at
16664708
204893_PM_s_at
204893_s_at
208446_PM_s_at
208446_s_at
2336305
2336306
2336307
2336308
2336321
2336322
2336323
2336324
2336325
2336326
2336327
2336328
2336335
2336339
2336341
2336342
2336343
2336344
2336347
2336350
2336354
2336356
2336357
2336360
2336361
2336363
2336364
2336365
2336366
2336368
3615376
38889_at
3992804
3992805
3992808
3992810
7901426
9372
A_14_P101368
A_23_P33768
GE62107
GO:0005515
GO:0005545
GO:0005737
GO:0005768
GO:0005769
GO:0005829
GO:0006897
GO:0007179
GO:0008289
GO:0016020
GO:0016192
GO:0016197
GO:0019904
GO:0023052
GO:0031410
GO:0031901
GO:0032991
GO:0043226
GO:0043231
GO:0046872
HMNXSV003026189
ILMN_1776848
ILMN_1799622
ILMN_2381994
PH_hs_0027270
TC01000639.hg
g4759059_3p_a_at
g6552336_3p_a_at
g6552336_3p_x_at
Participates
as a component of
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 Phosphorylation Motif Mutants [early endosome membrane] (Homo sapiens)
TGFB1:p-TGFBR:Smad7:GADD34:PP1CC:SARA [early endosome membrane] (Homo sapiens)
TGFB1:p-TGFBR:I-SMAD7:GADD34:PP1:ZFYVE9 [early endosome membrane] (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:SMAD2/3 [early endosome membrane] (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9 [early endosome membrane] (Homo sapiens)
TGFB1:p-TGFBR:ZFYVE9:p-2S-SMAD2,3 [early endosome membrane] (Homo sapiens)
as an input of
An anchoring protein ZFYVE9 (SARA) does not recruit SMAD2/3 to TGFB1:TGFBR2:p-TGFBR1 KD Mutants (Homo sapiens)
Smad7 recruits GADD34:PP1CC to phosphorylated TGF-beta receptor complex (Homo sapiens)
SMAD7 recruits GADD34:PP1 to phosphorylated TGFBR (Homo sapiens)
An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 (Homo sapiens)
as an output of
PP1CC dephosphorylates TGFBR1 (Homo sapiens)
PP1 dephosphorylates TGFBR1 (Homo sapiens)
Inferred To
ZFYVE9 [early endosome membrane]
(Bos taurus)
ZFYVE9 [early endosome membrane]
(Canis familiaris)
ZFYVE9 [early endosome membrane]
(Gallus gallus)
ZFYVE9 [early endosome membrane]
(Sus scrofa)
Sara [early endosome membrane]
(Drosophila melanogaster)
ZFYVE9-1 [early endosome membrane]
(Danio rerio)
Zfyve9 [early endosome membrane]
(Mus musculus)
Zfyve9 [early endosome membrane]
(Rattus norvegicus)
aka-1 [early endosome membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_015563.2
,
NP_004790.2
,
XP_011540739.1
OpenTargets
ENSG00000157077
HPA
ENSG00000157077-ZFYVE9
GeneCards
O95405
Ensembl
ENSP00000349737
,
ENSP00000287727
,
ENSP00000360647
,
ENST00000371591
,
ENST00000287727
,
ENST00000357206
,
ENSG00000157077
PRO
O95405
Pharos - Targets
O95405
PDB
5MJY
,
1DEV
,
4BKW
,
1MK2
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15796 SMAD2
20
Ub-SMAD2 [cytosol]
(R-HSA-6782774)
p-S465,S467-SMAD2 P305L [cytosol]
(R-HSA-3315471)
p-S465,S467-SMAD2 D300A [cytosol]
(R-HSA-3315064)
p-S465,S467-SMAD2 D300N [cytosol]
(R-HSA-3315066)
p-S465,S467-SMAD2 A354T [cytosol]
(R-HSA-3315474)
p-S465,S467-SMAD2 P305Q [cytosol]
(R-HSA-3315070)
p-S465,S467-SMAD2 D300V [cytosol]
(R-HSA-3315067)
SMAD2 S464* [cytosol]
(R-HSA-3304362)
SMAD2 W422* [cytosol]
(R-HSA-9668736)
SMAD2 S308* [cytosol]
(R-HSA-9668732)
SMAD2 R427* [cytosol]
(R-HSA-9668733)
SMAD2 W448* [cytosol]
(R-HSA-9668734)
SMAD2 S464L [cytosol]
(R-HSA-3304383)
SMAD2 C463* [cytosol]
(R-HSA-9668735)
SMAD2 R321* [cytosol]
(R-HSA-9668728)
SMAD2 S296* [cytosol]
(R-HSA-9668729)
SMAD2 S306* [cytosol]
(R-HSA-9668730)
SMAD2 Q455* [cytosol]
(R-HSA-9668731)
SMAD2 E439* [cytosol]
(R-HSA-9668724)
SMAD2 L315* [cytosol]
(R-HSA-9668725)
0.783
6
UniProt:P84022 SMAD3
20
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
p-S208-SMAD3 [cytosol]
(R-HSA-9731114)
SMAD3 [nucleoplasm]
(R-HSA-206150)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
Ub,p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-9773841)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
0.764
5
UniProt:P36873 PPP1CC
1
PPP1CC [cytosol]
(R-HSA-163443)
0.743
5
UniProt:Q13277 STX3
1
STX3 [plasma membrane]
(R-HSA-449131)
0.571
3
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.553
3
UniProt:P08100 RHO
8
RHO [ciliary membrane]
(R-HSA-5623404)
RHO [Golgi-associated vesicle membrane]
(R-HSA-5623406)
RHO [Golgi membrane]
(R-HSA-5623400)
11c-retinyl-RHO [photoreceptor disc membrane]
(R-HSA-5205900)
at-retinyl-RHO [photoreceptor disc membrane]
(R-HSA-5205901)
p-S334,338,343-at-retinyl-RHO [photoreceptor disc membrane]
(R-HSA-5205903)
p-S334,338,343-RHO [photoreceptor disc membrane]
(R-HSA-2581504)
RHO [photoreceptor disc membrane]
(R-HSA-419802)
0.544
2
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