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TJP2 [cytosol]
Stable Identifier
R-HSA-2064412
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ZO-2, Tight junction protein 2, Zonula occludens protein 2
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Hippo (Homo sapiens)
Translocation of YAP1:ZO-2 (TJP2) to the nucleus (Homo sapiens)
YAP1:TJP2 [cytosol] (Homo sapiens)
TJP2 [cytosol] (Homo sapiens)
WWTR1 (TAZ) binds ZO-2 (TJP2) (Homo sapiens)
TJP2 [cytosol] (Homo sapiens)
WWTR1:TJP2 [cytosol] (Homo sapiens)
TJP2 [cytosol] (Homo sapiens)
YAP1 binds ZO-2 (TJP2) (Homo sapiens)
TJP2 [cytosol] (Homo sapiens)
YAP1:TJP2 [cytosol] (Homo sapiens)
TJP2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UDY2 TJP2
Gene Names
TJP2, X104, ZO2
Chain
chain:1-1190
Reference Genes
BioGPS Gene:9414 TJP2
COSMIC (genes):TJP2 TJP2
CTD Gene:9414 TJP2
dbSNP Gene:9414 TJP2
ENSEMBL:ENSG00000119139 TJP2
ENSEMBL_homo_sapiens_GENE:ENSG00000119139.21 TJP2
HGNC:11828 TJP2
KEGG Gene (Homo sapiens):9414 TJP2
Monarch:9414 TJP2
NCBI Gene:9414 TJP2
OMIM:607709 TJP2
UCSC:Q9UDY2 TJP2
Reference Transcript
RefSeq:XM_011519207.2 TJP2
RefSeq:NM_001170416.1 TJP2
RefSeq:XM_011519206.2 TJP2
RefSeq:XM_011519208.2 TJP2
RefSeq:NM_001170415.1 TJP2
RefSeq:NM_004817.3 TJP2
RefSeq:XM_011519209.2 TJP2
Other Identifiers
11716742_a_at
11716743_s_at
11716744_x_at
11745848_a_at
11751951_a_at
11756897_x_at
17085685
202085_PM_at
202085_at
3173886
3173887
3173888
3173889
3173890
3173892
3173893
3173895
3173896
3173897
3173898
3173900
3173901
3173902
3173903
3173904
3173905
3173906
3173908
3173911
3173912
3173916
3173919
3173920
3173921
3173922
3173927
3173928
3173929
36655_at
8155707
9414
A_23_P9293
GE57705
GO:0003013
GO:0003824
GO:0004385
GO:0005515
GO:0005634
GO:0005654
GO:0005829
GO:0005886
GO:0005912
GO:0005923
GO:0007155
GO:0010033
GO:0016020
GO:0016740
GO:0019904
GO:0022600
GO:0030154
GO:0030674
GO:0034109
GO:0034330
GO:0035633
GO:0043226
GO:0044291
GO:0044325
GO:0045216
GO:0045296
GO:0046037
GO:0046710
GO:0048856
GO:0050839
GO:0050892
GO:0055086
GO:0060090
GO:0070160
GO:0070161
GO:0090557
GO:0090559
GO:0098609
GO:0150105
GO:1901135
GO:1905605
GO:1990782
HMNXSV003022400
HMNXSV003023127
ILMN_1664978
ILMN_1763972
ILMN_2384561
L27476_at
PH_hs_0004346
TC09001995.hg
TC09001996.hg
g4759341_3p_at
Participates
as a component of
WWTR1:TJP2 [cytosol] (Homo sapiens)
YAP1:TJP2 [cytosol] (Homo sapiens)
as an input of
WWTR1 (TAZ) binds ZO-2 (TJP2) (Homo sapiens)
YAP1 binds ZO-2 (TJP2) (Homo sapiens)
Other forms of this molecule
TJP2 [plasma membrane]
TJP2(?-?) [plasma membrane]
TJP2 [nucleoplasm]
Inferred To
zoo-1 [cytosol]
(Caenorhabditis elegans)
TJP2 [cytosol]
(Bos taurus)
TJP2 [cytosol]
(Canis familiaris)
TJP2 [cytosol]
(Gallus gallus)
TJP2 [cytosol]
(Sus scrofa)
Tjp2 [cytosol]
(Mus musculus)
Tjp2 [cytosol]
(Rattus norvegicus)
tjp2 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
XP_011517508.1
,
XP_011517509.1
,
NP_001163886.1
,
XP_011517511.1
,
XP_011517510.1
,
NP_004808.2
,
NP_001163887.1
OpenTargets
ENSG00000119139
HPA
ENSG00000119139-TJP2
GeneCards
Q9UDY2
Ensembl
ENSP00000366453
,
ENST00000539225
,
ENSP00000442090
,
ENST00000348208
,
ENSG00000119139
,
ENSP00000438262
,
ENSP00000345893
,
ENST00000377245
,
ENST00000535702
PRO
Q9UDY2
Pharos - Targets
Q9UDY2
Orphanet
19466
PDB
3E17
,
2OSG
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.862
7
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.714
8
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.688
3
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.671
4
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.589
2
UniProt:Q14847 LASP1
0.584
9
UniProt:Q8WVZ9 KBTBD7
1
KBTBD7 [cytosol]
(R-HSA-5658415)
0.527
3
UniProt:P78362 SRPK2
1
SRPK2 [cytosol]
(R-HSA-9729332)
0.527
2
UniProt:Q15139 PRKD1
1
PRKD1 [cytosol]
(R-HSA-58210)
0.527
2
UniProt:Q96HS1 PGAM5
0.483
2
UniProt:Q66GS9 CEP135
1
CEP135 [cytosol]
(R-HSA-380266)
0.483
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
13
UniProt:Q07157 TJP1
5
TJP1 [cell junction]
(R-HSA-8936023)
TJP1 (?-?) [plasma membrane]
(R-HSA-3209844)
TJP1 [plasma membrane]
(R-HSA-3209845)
TJP1 [Golgi-associated vesicle membrane]
(R-HSA-3209843)
TJP1 [cytosol]
(R-HSA-532659)
0.483
3
UniProt:Q15058 KIF14
1
KIF14 [cytosol]
(R-HSA-1629804)
0.483
2
UniProt:Q9NQT4 EXOSC5
2
EXOSC5 [cytosol]
(R-HSA-429889)
EXOSC5 [nucleoplasm]
(R-HSA-6791550)
0.483
2
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