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D4S-BCAN [lysosomal lumen]
Stable Identifier
R-HSA-2065208
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal lumen
Synonyms
Brevican core protein, PGCB_HUMAN, BCAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Chondroitin sulfate/dermatan sulfate metabolism (Homo sapiens)
CS/DS degradation (Homo sapiens)
DSPG and CSPG translocate to the lysosome for degradation (Homo sapiens)
DSPGs [lysosomal lumen] (Homo sapiens)
D4S-PGs [lysosomal lumen] (Homo sapiens)
D4S-BCAN [lysosomal lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96GW7 BCAN
Gene Names
BCAN, BEHAB, CSPG7, UNQ2525/PRO6018
Chain
signal peptide:1-22, chain:23-911
Reference Genes
BioGPS Gene:63827 BCAN
COSMIC (genes):BCAN BCAN
CTD Gene:63827 BCAN
dbSNP Gene:63827 BCAN
ENSEMBL:ENSG00000132692 BCAN
ENSEMBL_homo_sapiens_GENE:ENSG00000132692.19 BCAN
HGNC:23059 BCAN
KEGG Gene (Homo sapiens):63827 BCAN
Monarch:63827 BCAN
NCBI Gene:63827 BCAN
OMIM:600347 BCAN
UCSC:Q96GW7 BCAN
Reference Transcript
RefSeq:NM_021948.4 BCAN
RefSeq:XM_011509866.1 BCAN
RefSeq:NM_198427.1 BCAN
Other Identifiers
11719950_a_at
11728162_at
16672126
219107_PM_at
219107_at
221623_PM_at
221623_at
2361638
2361639
2361643
2361645
2361646
2361648
2361649
2361650
2361651
2361652
2361653
2361655
2361656
2361657
2361658
2361659
2361660
2361665
2361667
2361669
2361670
2361671
2361672
2361674
2361675
2361676
2361677
4920094C_3p_s_at
60064_g_at
63827
7906205
80560_at
91920_3p_at
91920_PM_at
91920_at
92116_at
A_14_P113766
A_23_P160607
A_24_P358554
GE56735
GO:0001501
GO:0002052
GO:0005515
GO:0005540
GO:0005576
GO:0005615
GO:0005764
GO:0005773
GO:0005794
GO:0005796
GO:0007155
GO:0007417
GO:0010001
GO:0016020
GO:0021766
GO:0030154
GO:0030246
GO:0030312
GO:0031012
GO:0034330
GO:0043202
GO:0043226
GO:0045202
GO:0048856
GO:0060074
GO:0072534
GO:0098552
GO:0098978
HMNXSV003004458
ILMN_1680300
ILMN_1732154
ILMN_2246131
PH_hs_0022733
TC01001325.hg
g10798902_3p_at
g10798902_3p_x_at
g11345493_3p_at
Participates
as a member of
D4S-PGs [lysosomal lumen] (Homo sapiens)
Other forms of this molecule
D2,4,4(S)3-BCAN(361-911) [extracellular region]
CSE-BCAN(361-911) [extracellular region]
C6S-BCAN(361-911) [extracellular region]
C4S-BCAN(361-911) [extracellular region]
D2,4(S)2-BCAN(361-911) [extracellular region]
D4S-BCAN(361-911) [extracellular region]
D4S-BCAN(23-360) [extracellular region]
D2,4(S)2-BCAN(23-360) [extracellular region]
C6S-BCAN(23-360) [extracellular region]
D2,4,4(S)3-BCAN(23-360) [extracellular region]
C4S-BCAN(23-360) [extracellular region]
CSE-BCAN(23-360) [extracellular region]
D2,4(S)2-BCAN(23-395) [extracellular region]
D2,4,4(S)3-BCAN(23-395) [extracellular region]
C6S-BCAN(23-395) [extracellular region]
C4S-BCAN(23-395) [extracellular region]
D4S-BCAN(23-395) [extracellular region]
CSE-BCAN(23-395) [extracellular region]
C4S-BCAN(396-911) [extracellular region]
D2,4,4(S)3-BCAN(396-911) [extracellular region]
C6S-BCAN(396-911) [extracellular region]
D4S-BCAN(396-911) [extracellular region]
CSE-BCAN(396-911) [extracellular region]
D2,4(S)2-BCAN(396-911) [extracellular region]
dermatan-BCAN [Golgi lumen]
D2,4(S)2-BCAN [Golgi lumen]
D2,4,4(S)3-BCAN [Golgi lumen]
D4S-BCAN [Golgi lumen]
CSE-BCAN [lysosomal lumen]
C6S-BCAN [lysosomal lumen]
C4S-BCAN [lysosomal lumen]
D2,4(S)2-BCAN [lysosomal lumen]
D4S-BCAN [extracellular region]
D2,4(S)2-BCAN [extracellular region]
D2,4,4(S)3-BCAN [extracellular region]
BCAN [lysosomal lumen]
D2,4,4(S)3-BCAN [lysosomal lumen]
CSE-BCAN [extracellular region]
C6S-BCAN [extracellular region]
C4S-BCAN [extracellular region]
CSE-BCAN [Golgi lumen]
C6S-BCAN [Golgi lumen]
Gal-Gal-Xyl-BCAN [Golgi lumen]
GlcA-Gal-Gal-Xyl-BCAN [Golgi lumen]
Gal-Xyl-BCAN [Golgi lumen]
XylS-BCAN [Golgi lumen]
BCAN [Golgi lumen]
chondroitin(1)-BCAN [Golgi lumen]
chondroitin(2)-BCAN [Golgi lumen]
chondroitin(3)-BCAN [Golgi lumen]
C4S-BCAN [Golgi lumen]
Inferred To
Bcan [lysosomal lumen]
(Mus musculus)
Bcan [lysosomal lumen]
(Rattus norvegicus)
D4S-BCAN [lysosomal lumen]
(Gallus gallus)
BCAN [lysosomal lumen]
(Bos taurus)
BCAN [lysosomal lumen]
(Canis familiaris)
BCAN [lysosomal lumen]
(Sus scrofa)
bcan [lysosomal lumen]
(Danio rerio)
bcan [lysosomal lumen]
(Xenopus tropicalis)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63516) at unknown position
Modification
beta-D-GalNAc-(1->4)-beta-D-IdoA-(1->3)-beta-D-GalNAc4S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_068767.3
,
NP_940819.1
,
XP_011508168.1
OpenTargets
ENSG00000132692
HPA
ENSG00000132692-BCAN
GeneCards
Q96GW7
Ensembl
ENST00000329117
,
ENSP00000354925
,
ENST00000361588
,
ENSP00000331210
,
ENSG00000132692
PRO
Q96GW7
Pharos - Targets
Q96GW7
HMDB Protein
HMDBP02632
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P07948 LYN
7
MyrG2-PalmC3-LYN [lysosomal membrane]
(R-HSA-9707903)
MyrG2-PalmC3-LYN [endocytic vesicle membrane]
(R-HSA-9705728)
LYN [plasma membrane]
(R-HSA-197943)
p-Y397-LYN [cytosol]
(R-HSA-8942608)
p-Y397-LYN [plasma membrane]
(R-HSA-2454229)
MyrG2-PalmC3-LYN [plasma membrane]
(R-HSA-9606875)
LYN [cytosol]
(R-HSA-354251)
0.556
3
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