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HS(1)-AGRN [Golgi lumen]
Stable Identifier
R-HSA-2076350
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
AGRN, Agrin, AGRIN_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates and carbohydrate derivatives (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
HS-GAG biosynthesis (Homo sapiens)
GLCE epimerises GlcA to IdoA (Homo sapiens)
HS(1)-PGs [Golgi lumen] (Homo sapiens)
HS(1)-AGRN [Golgi lumen] (Homo sapiens)
NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS) (Homo sapiens)
HS(1)-PGs [Golgi lumen] (Homo sapiens)
HS(1)-AGRN [Golgi lumen] (Homo sapiens)
Some HSPGs are secreted to the plasma membrane (Homo sapiens)
HSPGs [Golgi lumen] (Homo sapiens)
HS(1)-PGs [Golgi lumen] (Homo sapiens)
HS(1)-AGRN [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00468 AGRN
Gene Names
AGRN, AGRIN
Chain
signal peptide:1-29, chain:30-2068, chain:30-1102, chain:1103-2068, chain:1103-1863, chain:1864-2068
Reference Genes
BioGPS Gene:375790 O004686
COSMIC (genes):AGRN AGRN
CTD Gene:375790 O004686
dbSNP Gene:375790 O004686
ENSEMBL:ENSG00000188157 AGRN
HGNC:329 O004686
KEGG:hsa:375790 O004686
Monarch:375790 O004686
NCBI Gene:375790 O004686
OMIM:103320 O004686
UCSC:O00468 O004686
Reference Transcript
RefSeq:NM_001305275.1 O004686
RefSeq:NM_198576.3 O004686
RefSeq:XM_005244749.3 O004686
Participates
as a member of
HS(1)-PGs [Golgi lumen] (Homo sapiens)
Other forms of this molecule
HS(4)-AGRN [plasma membrane]
HS(6)-AGRN [plasma membrane]
HS(2)-AGRN [plasma membrane]
HS(1)-AGRN [plasma membrane]
HS(3)-AGRN [plasma membrane]
HS(5)-AGRN [plasma membrane]
AGRN(30-2045) [extracellular region]
AGRN(30-2045) [Golgi lumen]
XylS-AGRN(30-2045) [Golgi lumen]
Gal-Xyl-AGRN [Golgi lumen]
Gal-Gal-Xyl-AGRN [Golgi lumen]
GlcA-Gal-Gal-Xyl-AGRN [Golgi lumen]
HS(2)-AGRN [Golgi lumen]
HS(3)-AGRN [Golgi lumen]
Heparan(4)-AGRN [Golgi lumen]
Heparan(3)-AGRN [Golgi lumen]
Heparan(2)-AGRN [Golgi lumen]
Heparan(1)-AGRN [Golgi lumen]
Heparan-AGRN [Golgi lumen]
HS(4)-AGRN [Golgi lumen]
HS(5)-AGRN [Golgi lumen]
HS(6)-AGRN [Golgi lumen]
HS(6)-AGRN [lysosomal lumen]
AGRN(30-2045) [lysosomal lumen]
Inferred To
HS(1)-AGRN [Golgi lumen]
(Caenorhabditis elegans)
HS(1)-AGRN [Golgi lumen]
(Mus musculus)
HS(1)-AGRN [Golgi lumen]
(Rattus norvegicus)
SP2353 [Golgi lumen]
(Drosophila melanogaster)
itx-1 [Golgi lumen]
(Caenorhabditis elegans)
Homologues of HS(1)-AGRN [Golgi lumen]
(Caenorhabditis elegans)
AGRN [Golgi lumen]
(Bos taurus)
AGRN [Golgi lumen]
(Canis familiaris)
AGRN [Golgi lumen]
(Sus scrofa)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63652) at unknown position
Modification
beta-D-GlcA-(1->4)-alpha-D-GlcNS-(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNS-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
XP_005244806.1
,
NP_940978.2
,
NP_001292204.1
OpenTargets
ENSG00000188157
ENSEMBL
ENSP00000368678
,
ENST00000379370
,
ENSG00000188157
GeneCards
AGRN
HPA
ENSG00000188157-AGRN
PRO
O00468
Pharos - Targets
O00468
GlyGen
O00468
Orphanet
AGRN
PDB
8S9P
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15530 PDPK1
3
PDPK1 [plasma membrane]
(R-HSA-61459)
PDPK1 [cytosol]
(R-HSA-202210)
p-S241-PDPK1 [cytosol]
(R-HSA-9860799)
0.527
2
UniProt:Q13438 OS9
1
OS9 [endoplasmic reticulum membrane]
(R-HSA-1022132)
0.527
3
UniProt:P02741 CRP
1
CRP(19-224) [extracellular region]
(R-HSA-976719)
0.527
3
UniProt:O15265 ATXN7
2
ATXN7 [nucleoplasm]
(R-HSA-8869458)
ATXN7 [cytosol]
(R-HSA-201591)
0.508
2
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