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Heparan(2)-GPC3 [Golgi lumen]
Stable Identifier
R-HSA-2076409
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
GPC3, Glypican-3, GPC3_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of glycosylation (Homo sapiens)
Diseases associated with glycosaminoglycan metabolism (Homo sapiens)
Defective EXT1 causes exostoses 1, TRPS2 and CHDS (Homo sapiens)
Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)
Heparan(2)-PGs [Golgi lumen] (Homo sapiens)
Heparan(2)-GPC3 [Golgi lumen] (Homo sapiens)
Defective EXT2 causes exostoses 2 (Homo sapiens)
Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)
Heparan(2)-PGs [Golgi lumen] (Homo sapiens)
Heparan(2)-GPC3 [Golgi lumen] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
HS-GAG biosynthesis (Homo sapiens)
EXT1:EXT2 transfer GlcNAc to the heparan chain (Homo sapiens)
Heparan(2)-PGs [Golgi lumen] (Homo sapiens)
Heparan(2)-GPC3 [Golgi lumen] (Homo sapiens)
EXT1:EXT2 transfers GlcA to heparan (Homo sapiens)
Heparan(2)-PGs [Golgi lumen] (Homo sapiens)
Heparan(2)-GPC3 [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51654 GPC3
Gene Names
GPC3, OCI5
Chain
signal peptide:1-24, chain:25-358, chain:359-554, propeptide:555-580
Reference Genes
BioGPS Gene:2719 GPC3
COSMIC (genes):GPC3 GPC3
CTD Gene:2719 GPC3
dbSNP Gene:2719 GPC3
ENSEMBL:ENSG00000147257 GPC3
ENSEMBL_homo_sapiens_GENE:ENSG00000147257.16 GPC3
HGNC:4451 GPC3
KEGG Gene (Homo sapiens):2719 GPC3
Monarch:2719 GPC3
NCBI Gene:2719 GPC3
OMIM:300037 GPC3
UCSC:P51654 GPC3
Reference Transcript
RefSeq:NM_001164617.1 GPC3
RefSeq:NM_001164619.1 GPC3
RefSeq:NM_004484.3 GPC3
Other Identifiers
11729604_s_at
11752479_a_at
11754011_x_at
17114288
209220_PM_at
209220_at
2719
39350_at
4022458
4022459
4022460
4022461
4022462
4022463
4022479
4022499
4022506
4022508
4022517
4022518
4022567
4022568
4022583
4022584
8175234
A_33_P3230264
A_33_P3326634
GE58338
GO:0001658
GO:0001822
GO:0005515
GO:0005764
GO:0005773
GO:0005783
GO:0005788
GO:0005794
GO:0005796
GO:0005886
GO:0007224
GO:0008285
GO:0009617
GO:0009653
GO:0009887
GO:0009948
GO:0009966
GO:0009986
GO:0010171
GO:0016020
GO:0016192
GO:0016477
GO:0023052
GO:0030154
GO:0030163
GO:0030282
GO:0030312
GO:0030316
GO:0030324
GO:0030414
GO:0030513
GO:0031012
GO:0035116
GO:0040008
GO:0042074
GO:0043202
GO:0043226
GO:0045732
GO:0045807
GO:0045879
GO:0045880
GO:0045926
GO:0046326
GO:0048856
GO:0048870
GO:0050673
GO:0050680
GO:0055085
GO:0060070
GO:0060071
GO:0060422
GO:0060828
GO:0060976
GO:0062023
GO:0072111
GO:0072138
GO:0072180
GO:0072203
GO:0090090
GO:0090263
GO:0098552
GO:0098772
GO:1905475
GO:2000050
GO:2000096
HMNXSV003050256
ILMN_2051972
L47125_s_at
PH_hs_0006599
TC0X001378.hg
Z37987_s_at
g1237180_3p_at
Participates
as a member of
Heparan(2)-PGs [Golgi lumen] (Homo sapiens)
Other forms of this molecule
GPC3(25-?) [lysosomal lumen]
HS(6)-GPC3 [lysosomal lumen]
HS(1)-GPC3 [Golgi lumen]
HS(2)-GPC3 [Golgi lumen]
HS(3)-GPC3 [Golgi lumen]
HS(4)-GPC3 [Golgi lumen]
HS(6)-GPC3 [Golgi lumen]
HS(5)-GPC3 [Golgi lumen]
Heparan-GPC3 [Golgi lumen]
Heparan(1)-GPC3 [Golgi lumen]
Heparan(4)-GPC3 [Golgi lumen]
Heparan(3)-GPC3 [Golgi lumen]
GPC3(25-?) [Golgi lumen]
XylS-GPC3(25-?) [Golgi lumen]
Gal-Xyl-GPC3 [Golgi lumen]
GlcA-Gal-Gal-Xyl-GPC3 [Golgi lumen]
Gal-Gal-Xyl-GPC3 [Golgi lumen]
p-GPC3 [endoplasmic reticulum lumen]
HS(4)-GPC3 [plasma membrane]
HS(6)-GPC3 [plasma membrane]
HS(2)-GPC3 [plasma membrane]
HS(1)-GPC3 [plasma membrane]
HS(3)-GPC3 [plasma membrane]
HS(5)-GPC3 [plasma membrane]
GPC3 [endoplasmic reticulum lumen]
Inferred To
GPC3 [Golgi lumen]
(Bos taurus)
GPC3 [Golgi lumen]
(Canis familiaris)
GPC3 [Golgi lumen]
(Sus scrofa)
Heparan(2)-GPC3 [Golgi lumen]
(Gallus gallus)
Gpc3 [Golgi lumen]
(Mus musculus)
Gpc3 [Golgi lumen]
(Rattus norvegicus)
gpc3 [Golgi lumen]
(Danio rerio)
gpc3 [Golgi lumen]
(Xenopus tropicalis)
dally [Golgi lumen]
(Drosophila melanogaster)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63648) at unknown position
Modification
alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_001158091.1
,
NP_004475.1
,
NP_001158089.1
Guide to Pharmacology - Targets
2959
OpenTargets
ENSG00000147257
GeneCards
P51654
HPA
ENSG00000147257-GPC3
Ensembl
ENSP00000486325
,
ENSG00000147257
,
ENSP00000359854
,
ENSP00000377836
,
ENST00000370818
,
ENST00000631057
,
ENST00000394299
PRO
P51654
Pharos - Targets
P51654
Orphanet
16160
PDB
7ZA1
,
7ZAW
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P32249 GPR183
1
GPR183 [plasma membrane]
(R-HSA-8851676)
0.527
3
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