Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
HS(5)-GPC4 [Golgi lumen]
Stable Identifier
R-HSA-2076488
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
GPC4, Glypican-4, GPC4_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
HS-GAG biosynthesis (Homo sapiens)
GLCE epimerises more GlcA to IdoA as sulfate content rises (Homo sapiens)
HS(5)-PGs [Golgi lumen] (Homo sapiens)
HS(5)-GPC4 [Golgi lumen] (Homo sapiens)
HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Homo sapiens)
HS(5)-PGs [Golgi lumen] (Homo sapiens)
HS(5)-GPC4 [Golgi lumen] (Homo sapiens)
Some HSPGs are secreted to the plasma membrane (Homo sapiens)
HSPGs [Golgi lumen] (Homo sapiens)
HS(5)-PGs [Golgi lumen] (Homo sapiens)
HS(5)-GPC4 [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75487 GPC4
Gene Names
GPC4, UNQ474/PRO937
Chain
signal peptide:1-18, chain:19-529, chain:19-, propeptide:530-556
Reference Genes
BioGPS Gene:2239 GPC4
COSMIC (genes):GPC4 GPC4
CTD Gene:2239 GPC4
dbSNP Gene:2239 GPC4
ENSEMBL:ENSG00000076716 GPC4
HGNC:4452 GPC4
KEGG:hsa:2239 GPC4
Monarch:2239 GPC4
NCBI Gene:2239 GPC4
OMIM:300168 GPC4
UCSC:O75487 GPC4
Reference Transcript
RefSeq:NM_001448.2 GPC4
Other Identifiers
11727403_at
11727404_a_at
11758979_at
17114272
204983_PM_s_at
204983_s_at
204984_PM_at
204984_at
2239
36508_at
4022380
4022381
4022382
4022383
4022384
4022385
4022386
4022387
4022389
4022390
4022391
4022392
4022393
4022396
4022405
4022411
4022438
4022439
52756_at
8175217
A_23_P435407
GE54232
GO:0005515
GO:0005576
GO:0005634
GO:0005794
GO:0005796
GO:0005886
GO:0007155
GO:0009897
GO:0009966
GO:0009986
GO:0015026
GO:0016055
GO:0016477
GO:0030312
GO:0031012
GO:0043202
GO:0043226
GO:0045202
GO:0048870
GO:0060089
GO:0062023
GO:0070062
GO:0098552
GO:0098696
GO:0098978
GO:0099560
GO:1905606
HMNXSV003012893
ILMN_1789502
PH_hs_0003752
TC0X001376.hg
g3420276_3p_a_at
g4504082_3p_at
Participates
as a member of
HS(5)-PGs [Golgi lumen] (Homo sapiens)
Other forms of this molecule
HS(4)-GPC4 [plasma membrane]
HS(6)-GPC4 [plasma membrane]
HS(2)-GPC4 [plasma membrane]
HS(1)-GPC4 [plasma membrane]
HS(3)-GPC4 [plasma membrane]
HS(5)-GPC4 [plasma membrane]
XylS-GPC4 [Golgi lumen]
Gal-Xyl-GPC4 [Golgi lumen]
GPC4 [Golgi lumen]
Gal-Gal-Xyl-GPC4 [Golgi lumen]
GlcA-Gal-Gal-Xyl-GPC4 [Golgi lumen]
HS(3)-GPC4 [Golgi lumen]
HS(4)-GPC4 [Golgi lumen]
HS(2)-GPC4 [Golgi lumen]
HS(1)-GPC4 [Golgi lumen]
Heparan(4)-GPC4 [Golgi lumen]
Heparan(3)-GPC4 [Golgi lumen]
Heparan(2)-GPC4 [Golgi lumen]
Heparan(1)-GPC4 [Golgi lumen]
Heparan-GPC4 [Golgi lumen]
HS(6)-GPC4 [Golgi lumen]
HS(6)-GPC4 [lysosomal lumen]
GPC4 [lysosomal lumen]
Inferred To
gpc4 [Golgi lumen]
(Danio rerio)
gpc4 [Golgi lumen]
(Xenopus tropicalis)
GPC4 [Golgi lumen]
(Bos taurus)
GPC4 [Golgi lumen]
(Canis familiaris)
GPC4 [Golgi lumen]
(Sus scrofa)
HS(5)-GPC4 [Golgi lumen]
(Gallus gallus)
dlp [Golgi lumen]
(Drosophila melanogaster)
gpn-1 [Golgi lumen]
(Caenorhabditis elegans)
Gpc4 [Golgi lumen]
(Mus musculus)
Gpc4 [Golgi lumen]
(Rattus norvegicus)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63661) at unknown position
Modification
beta-D-IdoA-(1->4)-alpha-D-GlcNS-(1->4)-beta-D-IdoA2S-(1->4)-alpha-D-GlcNS3S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_001439.2
OpenTargets
ENSG00000076716
ENSEMBL
ENST00000370828
,
ENSP00000359864
HPA
ENSG00000076716-GPC4
PRO
O75487
Pharos - Targets
O75487
GlyGen
O75487
Orphanet
GPC4
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:O15530 PDPK1
3
p-S241-PDPK1 [cytosol]
(R-HSA-9860799)
PDPK1 [cytosol]
(R-HSA-202210)
PDPK1 [plasma membrane]
(R-HSA-61459)
0.527
2
UniProt:P32249 GPR183
1
GPR183 [plasma membrane]
(R-HSA-8851676)
0.527
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text