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HS(4)-HSPG2 [Golgi lumen]
Stable Identifier
R-HSA-2076495
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
HSPG2, Perlecan
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates and carbohydrate derivatives (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
HS-GAG biosynthesis (Homo sapiens)
GLCE epimerises more GlcA to IdoA as sulfate content rises (Homo sapiens)
HS(4)-PGs [Golgi lumen] (Homo sapiens)
HS(4)-HSPG2 [Golgi lumen] (Homo sapiens)
HS3ST1 sulfates GlcN at C3 in heparan sulfate (Homo sapiens)
HS(4)-PGs [Golgi lumen] (Homo sapiens)
HS(4)-HSPG2 [Golgi lumen] (Homo sapiens)
HS3STs sulfate GlcN at C3 in heparan sulfate (Homo sapiens)
HS(4)-PGs [Golgi lumen] (Homo sapiens)
HS(4)-HSPG2 [Golgi lumen] (Homo sapiens)
Some HSPGs are secreted to the plasma membrane (Homo sapiens)
HSPGs [Golgi lumen] (Homo sapiens)
HS(4)-PGs [Golgi lumen] (Homo sapiens)
HS(4)-HSPG2 [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P98160 HSPG2
Gene Names
HSPG2
Chain
signal peptide:1-21, chain:22-4391, chain:3687-4391, chain:4197-4391
Reference Genes
BioGPS Gene:3339 HSPG2
COSMIC (genes):HSPG2 HSPG2
CTD Gene:3339 HSPG2
dbSNP Gene:3339 HSPG2
ENSEMBL:ENSG00000142798 HSPG2
HGNC:5273 HSPG2
KEGG:hsa:3339 HSPG2
Monarch:3339 HSPG2
NCBI Gene:3339 HSPG2
OMIM:142461 HSPG2
UCSC:P98160 HSPG2
Reference Transcript
RefSeq:NM_005529.6 HSPG2
RefSeq:NM_001291860.1 HSPG2
Participates
as a member of
HS(4)-PGs [Golgi lumen] (Homo sapiens)
Other forms of this molecule
HSPG2(22-4196) [extracellular region]
HS(4)-HSPG2 [plasma membrane]
HS(6)-HSPG2 [plasma membrane]
HS(2)-HSPG2 [plasma membrane]
HS(1)-HSPG2 [plasma membrane]
HS(3)-HSPG2 [plasma membrane]
HS(5)-HSPG2 [plasma membrane]
HSPG2(3687-4391) [extracellular region]
HSPG2(22-4391) [Golgi lumen]
XylS-HSPG2(22-4391) [Golgi lumen]
Gal-Xyl-HSPG2 [Golgi lumen]
Gal-Gal-Xyl-HSPG2 [Golgi lumen]
GlcA-Gal-Gal-Xyl-HSPG2 [Golgi lumen]
HS(2)-HSPG2 [Golgi lumen]
HS(3)-HSPG2 [Golgi lumen]
HS(1)-HSPG2 [Golgi lumen]
Heparan(4)-HSPG2 [Golgi lumen]
Heparan(3)-HSPG2 [Golgi lumen]
Heparan(2)-HSPG2 [Golgi lumen]
Heparan(1)-HSPG2 [Golgi lumen]
Heparan-HSPG2 [Golgi lumen]
HS(5)-HSPG2 [Golgi lumen]
HS(6)-HSPG2 [Golgi lumen]
HS(6)-HSPG2 [lysosomal lumen]
HSPG2(22-4391) [lysosomal lumen]
HSPG2(22-4391) [extracellular region]
Heparan sulfate-HSPG2 [extracellular region]
HSPG2(?-4391) [extracellular region]
HSPG2(22-?) [extracellular region]
HSPG2(4197-4391) [extracellular region]
Inferred To
DIP-beta [Golgi lumen]
(Drosophila melanogaster)
CT35293 [Golgi lumen]
(Drosophila melanogaster)
CT35363 [Golgi lumen]
(Drosophila melanogaster)
DIP-eta [Golgi lumen]
(Drosophila melanogaster)
DIP-lambda [Golgi lumen]
(Drosophila melanogaster)
DIP-kappa [Golgi lumen]
(Drosophila melanogaster)
Homologues of HS(4)-HSPG2 [Golgi lumen]
(Caenorhabditis elegans)
Homologues of HS(4)-HSPG2 [Golgi lumen]
(Drosophila melanogaster)
fipi [Golgi lumen]
(Drosophila melanogaster)
Lac [Golgi lumen]
(Drosophila melanogaster)
DIP-gamma [Golgi lumen]
(Drosophila melanogaster)
DIP-alpha [Golgi lumen]
(Drosophila melanogaster)
rig-5 [Golgi lumen]
(Caenorhabditis elegans)
DIP-theta [Golgi lumen]
(Drosophila melanogaster)
DIP-delta [Golgi lumen]
(Drosophila melanogaster)
HS(4)-HSPG2 [Golgi lumen]
(Caenorhabditis elegans)
DIP-epsilon [Golgi lumen]
(Drosophila melanogaster)
DIP-zeta [Golgi lumen]
(Drosophila melanogaster)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63657) at unknown position
Modification
beta-D-GlcA-(1->4)-alpha-D-GlcNS-(1->4)-beta-D-IdoA2S-(1->4)-alpha-D-GlcNS3S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_001278789.1
,
NP_005520.4
OpenTargets
ENSG00000142798
ENSEMBL
ENST00000374695
,
ENSP00000363827
,
ENSG00000142798
GeneCards
HSPG2
HPA
ENSG00000142798-HSPG2
PRO
P98160
Pharos - Targets
P98160
GlyGen
P98160
Orphanet
HSPG2
HMDB Protein
HMDBP01713
PDB
3SH5
,
3SH4
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35968 KDR
5
p-6Y-VEGFR2 [plasma membrane]
(R-HSA-4420103)
VEGFR2 [plasma membrane]
(R-HSA-195382)
p-Y801,Y1054,Y1175-KDR [plasma membrane]
(R-HSA-9860484)
VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane]
(R-HSA-9673613)
p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane]
(R-HSA-9673636)
0.719
5
UniProt:P05230 FGF1
1
FGF1 [extracellular region]
(R-HSA-189856)
0.564
3
ChEBI:28304 HEPARIN
0.564
2
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.53
3
UniProt:Q9H9D4 ZN408
0.527
2
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