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Heparan-AGRN [Golgi lumen]
Stable Identifier
R-HSA-2076530
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
GlcA-Gal-Gal-Xyl-AGRN, Agrin, AGRIN_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Diseases of glycosylation (Homo sapiens)
Diseases associated with glycosaminoglycan metabolism (Homo sapiens)
Defective EXT1 causes exostoses 1, TRPS2 and CHDS (Homo sapiens)
Defective EXT1 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)
Heparan-PGs [Golgi lumen] (Homo sapiens)
Heparan-AGRN [Golgi lumen] (Homo sapiens)
Defective EXT2 causes exostoses 2 (Homo sapiens)
Defective EXT2 (in EXT1:EXT2) does not transfer GlcA to heparan (Homo sapiens)
Heparan-PGs [Golgi lumen] (Homo sapiens)
Heparan-AGRN [Golgi lumen] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
HS-GAG biosynthesis (Homo sapiens)
EXT1:EXT2 transfers GlcNAc to heparan (Homo sapiens)
Heparan-PGs [Golgi lumen] (Homo sapiens)
Heparan-AGRN [Golgi lumen] (Homo sapiens)
EXT1:EXT2 transfers GlcNAc to the terminal GlcA residue (Homo sapiens)
Heparan-PGs [Golgi lumen] (Homo sapiens)
Heparan-AGRN [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00468 AGRN
Gene Names
AGRN, AGRIN
Chain
signal peptide:1-29, chain:30-2068, chain:30-1102, chain:1103-2068, chain:1103-1863, chain:1864-2068
Reference Genes
COSMIC (genes):AGRN O004686
dbSNP Gene:375790 O004686
ENSEMBL:ENSG00000188157 AGRN
Participates
as a member of
Heparan-PGs [Golgi lumen] (Homo sapiens)
Other forms of this molecule
HS(4)-AGRN [plasma membrane]
HS(6)-AGRN [plasma membrane]
HS(2)-AGRN [plasma membrane]
HS(1)-AGRN [plasma membrane]
HS(3)-AGRN [plasma membrane]
HS(5)-AGRN [plasma membrane]
AGRN(30-2045) [extracellular region]
XylS-AGRN(30-2045) [Golgi lumen]
Gal-Xyl-AGRN [Golgi lumen]
AGRN(30-2045) [Golgi lumen]
Gal-Gal-Xyl-AGRN [Golgi lumen]
GlcA-Gal-Gal-Xyl-AGRN [Golgi lumen]
HS(3)-AGRN [Golgi lumen]
HS(4)-AGRN [Golgi lumen]
HS(2)-AGRN [Golgi lumen]
HS(1)-AGRN [Golgi lumen]
Heparan(4)-AGRN [Golgi lumen]
Heparan(3)-AGRN [Golgi lumen]
Heparan(2)-AGRN [Golgi lumen]
Heparan(1)-AGRN [Golgi lumen]
HS(5)-AGRN [Golgi lumen]
HS(6)-AGRN [Golgi lumen]
HS(6)-AGRN [lysosomal lumen]
AGRN(30-2045) [lysosomal lumen]
Inferred To
Heparan-AGRN [Golgi lumen]
(Caenorhabditis elegans)
Heparan-AGRN [Golgi lumen]
(Mus musculus)
Heparan-AGRN [Golgi lumen]
(Rattus norvegicus)
Homologues of Heparan-AGRN [Golgi lumen]
(Caenorhabditis elegans)
SP2353 [Golgi lumen]
(Drosophila melanogaster)
itx-1 [Golgi lumen]
(Caenorhabditis elegans)
AGRN [Golgi lumen]
(Bos taurus)
AGRN [Golgi lumen]
(Canis familiaris)
AGRN [Golgi lumen]
(Sus scrofa)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63645) at unknown position
Modification
alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15530 PDPK1
3
p-S241-PDPK1 [cytosol]
(R-HSA-9860799)
PDPK1 [cytosol]
(R-HSA-202210)
PDPK1 [plasma membrane]
(R-HSA-61459)
0.527
2
UniProt:Q13438 OS9
1
OS9 [endoplasmic reticulum membrane]
(R-HSA-1022132)
0.527
3
UniProt:P02741 CRP
1
CRP(19-224) [extracellular region]
(R-HSA-976719)
0.527
3
UniProt:O15265 ATXN7
2
ATXN7 [nucleoplasm]
(R-HSA-8869458)
ATXN7 [cytosol]
(R-HSA-201591)
0.508
2
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