Reactome | Heparan-AGRN [Golgi lumen]

Heparan-AGRN [Golgi lumen]

Stable Identifier

R-HSA-2076530

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi lumen

Synonyms

GlcA-Gal-Gal-Xyl-AGRN, Agrin, AGRIN_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O00468 AGRN

Gene Names

AGRN, AGRIN

Chain

signal peptide:1-29, chain:30-2068, chain:30-1102, chain:1103-2068, chain:1103-1863, chain:1864-2068

Reference Genes

BioGPS Gene:375790 O004686

COSMIC (genes):AGRN AGRN

CTD Gene:375790 O004686

dbSNP Gene:375790 AGRN

ENSEMBL:ENSG00000188157 AGRN

HGNC:329 O004686

KEGG:hsa:375790 O004686

Monarch:375790 O004686

NCBI Gene:375790 O004686

OMIM:103320 O004686

UCSC:O00468 O004686

Reference Transcript

Participates

as a member of

Heparan-PGs [Golgi lumen] (Homo sapiens)

Other forms of this molecule

HS(4)-AGRN [plasma membrane]

HS(6)-AGRN [plasma membrane]

HS(2)-AGRN [plasma membrane]

HS(1)-AGRN [plasma membrane]

HS(3)-AGRN [plasma membrane]

HS(5)-AGRN [plasma membrane]

AGRN(30-2068) [extracellular region]

Gal-Xyl-AGRN [Golgi lumen]

Gal-Gal-Xyl-AGRN [Golgi lumen]

XylS-AGRN(30-2068) [Golgi lumen]

AGRN(30-2068) [Golgi lumen]

GlcA-Gal-Gal-Xyl-AGRN [Golgi lumen]

HS(5)-AGRN [Golgi lumen]

HS(6)-AGRN [Golgi lumen]

HS(4)-AGRN [Golgi lumen]

HS(3)-AGRN [Golgi lumen]

HS(2)-AGRN [Golgi lumen]

HS(1)-AGRN [Golgi lumen]

Heparan(4)-AGRN [Golgi lumen]

Heparan(3)-AGRN [Golgi lumen]

Heparan(2)-AGRN [Golgi lumen]

Heparan(1)-AGRN [Golgi lumen]

HS(6)-AGRN [lysosomal lumen]

GlcA-Gal-Gal-XylP-AGRN [Golgi lumen]

Inferred To

Heparan-AGRN [Golgi lumen] (Caenorhabditis elegans)

Homologues of Heparan-AGRN [Golgi lumen] (Caenorhabditis elegans)

Agrn [Golgi lumen] (Mus musculus)

Agrn [Golgi lumen] (Rattus norvegicus)

SP2353 [Golgi lumen] (Drosophila melanogaster)

itx-1 [Golgi lumen] (Caenorhabditis elegans)

agrn [Golgi lumen] (Xenopus tropicalis)

AGRN [Golgi lumen] (Bos taurus)

AGRN [Golgi lumen] (Canis familiaris)

AGRN [Golgi lumen] (Sus scrofa)

Modified Residues

Name

O-xylosyl-L-serine (ChEBI:63645) at unknown position

Modification

alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group

PsiMod Name

O-xylosyl-L-serine

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O3-xylosylserine.

Cross References

RefSeq

NP_940978.2, XP_005244806.1, XP_054192447.1, NP_001292204.1

OpenTargets

ENSG00000188157

ENSEMBL

ENST00000379370, ENSP00000368678, ENSG00000188157

GeneCards

AGRN

HPA

ENSG00000188157-AGRN

PRO

O00468

Pharos - Targets

O00468

GlyGen

O00468

Orphanet

AGRN

PDB

8S9P

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02741 CRP	1	CRP(19-224) [extracellular region] (R-HSA-976719)	0.643	4
UniProt:Q13438 OS9	1	OS9 [endoplasmic reticulum membrane] (R-HSA-1022132)	0.527	3
UniProt:O15530 PDPK1	3	PDPK1 [plasma membrane] (R-HSA-61459) PDPK1 [cytosol] (R-HSA-202210) p-S241-PDPK1 [cytosol] (R-HSA-9860799)	0.527	2
UniProt:Q9UK22 FBXO2	1	FBXO2 [cytosol] (R-HSA-976044)	0.527	3
UniProt:P40939 HADHA	1	HADHA [mitochondrial inner membrane] (R-HSA-77264)	0.527	2
UniProt:Q8NCB2 CAMKV			0.527	3
UniProt:O15265 ATXN7	2	ATXN7 [cytosol] (R-HSA-201591) ATXN7 [nucleoplasm] (R-HSA-8869458)	0.508	2

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