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HS(6)-SDC2 [Golgi lumen]
Stable Identifier
R-HSA-2076588
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Golgi lumen
Synonyms
SDC2, HSPG, SDC2_HUMAN, Heparan sulfate proteoglycan core protein
Icon
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
HS-GAG biosynthesis (Homo sapiens)
HS6STs sulfate GlcN at C6 in heparan sulfate/heparin (Homo sapiens)
HS/HPIN-PGs [Golgi lumen] (Homo sapiens)
HS(6)-SDC2 [Golgi lumen] (Homo sapiens)
Some HSPGs are secreted to the plasma membrane (Homo sapiens)
HSPGs [Golgi lumen] (Homo sapiens)
HS/HPIN-PGs [Golgi lumen] (Homo sapiens)
HS(6)-SDC2 [Golgi lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P34741 SDC2
Gene Names
SDC2, HSPG1
Chain
signal peptide:1-18, chain:19-201
Reference Genes
BioGPS Gene:6383 SDC2
COSMIC (genes):SDC2 SDC2
CTD Gene:6383 SDC2
dbSNP Gene:6383 SDC2
ENSEMBL:ENSG00000169439 SDC2
ENSEMBL_homo_sapiens_GENE:ENSG00000169439.12 SDC2
HGNC:10659 SDC2
KEGG Gene (Homo sapiens):6383 SDC2
Monarch:6383 SDC2
NCBI Gene:6383 SDC2
OMIM:142460 SDC2
UCSC:P34741 SDC2
Reference Transcript
RefSeq:NM_002998.3 SDC2
Other Identifiers
11720753_s_at
11745006_a_at
11745007_s_at
11746797_a_at
11746798_x_at
11751122_x_at
17071144
212154_PM_at
212154_at
212157_PM_at
212157_at
212158_PM_at
212158_at
3108152
3108153
3108154
3108155
3108156
3108157
3108158
3108184
3108185
3108186
3108187
3108188
3108189
3108190
3108191
3108192
3108210
3108212
39757_at
6383
65000_at
8147461
A_14_P109550
A_24_P380734
A_33_P3371219
GE57514
GO:0005515
GO:0005764
GO:0005773
GO:0005783
GO:0005788
GO:0005794
GO:0005796
GO:0005886
GO:0007399
GO:0008150
GO:0009986
GO:0016020
GO:0016477
GO:0030154
GO:0030165
GO:0030312
GO:0031012
GO:0042802
GO:0043202
GO:0043226
GO:0048813
GO:0048814
GO:0048856
GO:0048870
GO:0062023
HMNXSV003007453
Hs.1501.0.S1_3p_at
Hs.1501.0.S2_3p_at
Hs.1501.0.S3_3p_at
ILMN_1784553
J04621_at
PH_hs_0000201
TC08000590.hg
Participates
as a member of
HS/HPIN-PGs [Golgi lumen] (Homo sapiens)
Other forms of this molecule
SDC2 [plasma membrane]
p-Y179,Y191-SDC2 [plasma membrane]
SDC2 [lysosomal lumen]
HS(6)-SDC2 [lysosomal lumen]
HS(1)-SDC2 [Golgi lumen]
HS(2)-SDC2 [Golgi lumen]
HS(3)-SDC2 [Golgi lumen]
HS(4)-SDC2 [Golgi lumen]
HS(5)-SDC2 [Golgi lumen]
Heparan-SDC2 [Golgi lumen]
Heparan(1)-SDC2 [Golgi lumen]
Heparan(2)-SDC2 [Golgi lumen]
Heparan(4)-SDC2 [Golgi lumen]
Heparan(3)-SDC2 [Golgi lumen]
SDC2 [Golgi lumen]
HS(4)-SDC2 [plasma membrane]
HS(6)-SDC2 [plasma membrane]
HS(2)-SDC2 [plasma membrane]
HS(1)-SDC2 [plasma membrane]
HS(3)-SDC2 [plasma membrane]
HS(5)-SDC2 [plasma membrane]
SDC2 [endoplasmic reticulum lumen]
p-SDC2 [endoplasmic reticulum lumen]
Gal-Gal-Xyl-SDC2 [Golgi lumen]
GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen]
Gal-Xyl-SDC2 [Golgi lumen]
XylS-SDC2 [Golgi lumen]
Inferred To
SDC2 [Golgi lumen]
(Bos taurus)
SDC2 [Golgi lumen]
(Gallus gallus)
SDC2 [Golgi lumen]
(Sus scrofa)
sdc2 [Golgi lumen]
(Danio rerio)
sdc2 [Golgi lumen]
(Xenopus tropicalis)
Sdc [Golgi lumen]
(Drosophila melanogaster)
Sdc2 [Golgi lumen]
(Mus musculus)
Sdc2 [Golgi lumen]
(Rattus norvegicus)
sdn-1 [Golgi lumen]
(Caenorhabditis elegans)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63666) at unknown position
Modification
beta-D-IdoA-(1->4)-alpha-D-GlcNS6S-(1->4)-beta-D-IdoA2S-(1->4)-alpha-D-GlcNS3S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_002989.2
OpenTargets
ENSG00000169439
HPA
ENSG00000169439-SDC2
GeneCards
P34741
Ensembl
ENSP00000307046
,
ENST00000302190
,
ENSG00000169439
PRO
P34741
Pharos - Targets
P34741
HMDB Protein
HMDBP10737
PDB
6ITH
Interactors (48)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P34741 SDC2
20
SDC2 [plasma membrane]
(R-HSA-2090052)
p-Y179,Y191-SDC2 [plasma membrane]
(R-HSA-4093306)
SDC2 [lysosomal lumen]
(R-HSA-2090083)
HS(6)-SDC2 [lysosomal lumen]
(R-HSA-2090064)
HS(1)-SDC2 [Golgi lumen]
(R-HSA-2076607)
HS(2)-SDC2 [Golgi lumen]
(R-HSA-2076603)
HS(3)-SDC2 [Golgi lumen]
(R-HSA-2076443)
HS(4)-SDC2 [Golgi lumen]
(R-HSA-2076356)
HS(6)-SDC2 [Golgi lumen]
(R-HSA-2076588)
HS(5)-SDC2 [Golgi lumen]
(R-HSA-2076320)
Heparan-SDC2 [Golgi lumen]
(R-HSA-2076608)
Heparan(1)-SDC2 [Golgi lumen]
(R-HSA-2076536)
Heparan(2)-SDC2 [Golgi lumen]
(R-HSA-2076397)
Heparan(4)-SDC2 [Golgi lumen]
(R-HSA-2076576)
Heparan(3)-SDC2 [Golgi lumen]
(R-HSA-2076361)
SDC2 [Golgi lumen]
(R-HSA-2054101)
HS(4)-SDC2 [plasma membrane]
(R-HSA-2076683)
HS(6)-SDC2 [plasma membrane]
(R-HSA-2076661)
HS(2)-SDC2 [plasma membrane]
(R-HSA-2076644)
HS(1)-SDC2 [plasma membrane]
(R-HSA-2076643)
0.655
4
UniProt:P18827 SDC1
20
SDC1 [plasma membrane]
(R-HSA-174758)
SDC1 [lysosomal lumen]
(R-HSA-2090025)
HS(6)-SDC1 [lysosomal lumen]
(R-HSA-2090082)
HS(1)-SDC1 [Golgi lumen]
(R-HSA-2076321)
HS(2)-SDC1 [Golgi lumen]
(R-HSA-2076309)
HS(3)-SDC1 [Golgi lumen]
(R-HSA-2076444)
HS(4)-SDC1 [Golgi lumen]
(R-HSA-2076593)
HS(6)-SDC1 [Golgi lumen]
(R-HSA-2076520)
HS(5)-SDC1 [Golgi lumen]
(R-HSA-2076290)
Heparan-SDC1 [Golgi lumen]
(R-HSA-2076561)
Heparan(1)-SDC1 [Golgi lumen]
(R-HSA-2076349)
Heparan(2)-SDC1 [Golgi lumen]
(R-HSA-2076558)
Heparan(4)-SDC1 [Golgi lumen]
(R-HSA-2076339)
Heparan(3)-SDC1 [Golgi lumen]
(R-HSA-2076314)
SDC1 [Golgi lumen]
(R-HSA-2054105)
XylS-SDC1 [Golgi lumen]
(R-HSA-2064146)
Gal-Xyl-SDC1 [Golgi lumen]
(R-HSA-2064148)
HS(4)-SDC1 [plasma membrane]
(R-HSA-2076693)
HS(6)-SDC1 [plasma membrane]
(R-HSA-2076652)
HS(2)-SDC1 [plasma membrane]
(R-HSA-2076666)
0.59
3
UniProt:P31431 SDC4
20
SDC4 [lysosomal lumen]
(R-HSA-2090041)
HS(6)-SDC4 [lysosomal lumen]
(R-HSA-2090058)
HS(1)-SDC4 [Golgi lumen]
(R-HSA-2076434)
HS(2)-SDC4 [Golgi lumen]
(R-HSA-2076411)
HS(3)-SDC4 [Golgi lumen]
(R-HSA-2076418)
HS(4)-SDC4 [Golgi lumen]
(R-HSA-2076407)
HS(6)-SDC4 [Golgi lumen]
(R-HSA-2076330)
HS(5)-SDC4 [Golgi lumen]
(R-HSA-2076510)
Heparan-SDC4 [Golgi lumen]
(R-HSA-2076374)
Heparan(1)-SDC4 [Golgi lumen]
(R-HSA-2076394)
Heparan(2)-SDC4 [Golgi lumen]
(R-HSA-2076446)
Heparan(4)-SDC4 [Golgi lumen]
(R-HSA-2076613)
Heparan(3)-SDC4 [Golgi lumen]
(R-HSA-2076460)
SDC4 [Golgi lumen]
(R-HSA-2054111)
XylS-SDC4 [Golgi lumen]
(R-HSA-2064195)
HS(4)-SDC4 [plasma membrane]
(R-HSA-2076670)
HS(6)-SDC4 [plasma membrane]
(R-HSA-2076633)
HS(2)-SDC4 [plasma membrane]
(R-HSA-2076694)
HS(1)-SDC4 [plasma membrane]
(R-HSA-2076653)
HS(3)-SDC4 [plasma membrane]
(R-HSA-2076674)
0.59
4
UniProt:P41271-2 NBL1
0.556
3
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:Q9Y3C5 RNF11
0.556
3
UniProt:O60333-2 KIF1B
0.556
3
UniProt:O60506-4 SYNCRIP
0.556
3
UniProt:P28799-2 GRN
0.556
3
UniProt:Q13387-4 MAPK8IP2
0.556
3
UniProt:G5E9A7 G5E9A7
0.556
3
UniProt:P27986-2 PIK3R1
0.556
3
UniProt:Q6NXG1 ESRP1
3
ESRP1 [nucleoplasm]
(R-HSA-6803472)
ESRP1(1-606)-p-RAF1(227-648) fusion [cytosol]
(R-HSA-6802523)
ESRP1(1-606)-RAF1(227-648) fusion [cytosol]
(R-HSA-6802312)
0.556
3
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.556
3
UniProt:O15354 GPR37
1
GPR37 [plasma membrane]
(R-HSA-5333623)
0.556
3
UniProt:O60784-2 TOM1
0.556
3
IntAct:EBI-25834291 CCSB
0.556
3
UniProt:Q12797-6 ASPH
0.556
5
UniProt:Q63HN8 RNF213
3
RNF213(1-1172)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9715284)
RNF213(1-1172)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9715291)
RNF213 [cytosol]
(R-HSA-9635613)
0.527
2
UniProt:Q14592 ZNF460
1
ZNF460 [nucleoplasm]
(R-HSA-1027424)
0.527
2
UniProt:Q01831 XPC
5
XPC [nucleoplasm]
(R-HSA-67441)
Ub-XPC [nucleoplasm]
(R-HSA-6782944)
Ub,SUMO-XPC [nucleoplasm]
(R-HSA-6790460)
Ub,SUMO,K63polyUb-XPC [nucleoplasm]
(R-HSA-6790522)
monoSUMO1-K655-XPC [nucleoplasm]
(R-HSA-4570458)
0.527
2
UniProt:Q9Y5Q9 GTF3C3
1
GTF3C3 [nucleoplasm]
(R-HSA-83691)
0.527
2
UniProt:Q9UKD1 GMEB2
0.527
3
UniProt:P40939 HADHA
1
HADHA [mitochondrial inner membrane]
(R-HSA-77264)
0.527
3
UniProt:O14936 CASK
1
CASK [cytosol]
(R-HSA-373631)
0.527
2
UniProt:Q6AI08 HEAT6
0.527
2
UniProt:P55084 HADHB
1
HADHB [mitochondrial inner membrane]
(R-HSA-77266)
0.527
3
UniProt:Q8N441 FGFRL1
1
FGFRL1 [plasma membrane]
(R-HSA-197650)
0.527
3
UniProt:Q99985 SEM3C
0.527
3
UniProt:Q8NCB2 CAMKV
0.527
2
UniProt:O60645 EXOC3
2
EXOC3 [secretory granule membrane]
(R-HSA-2872286)
EXOC3 [cytosol]
(R-HSA-5623379)
0.527
2
UniProt:Q8WV41 SNX33
0.527
2
UniProt:P32249 GPR183
1
GPR183 [plasma membrane]
(R-HSA-8851676)
0.527
3
UniProt:P0C0S8 H2AC11
11
K63polyUb-HIST1H2AG [nucleoplasm]
(R-HSA-6783237)
Ub-HIST1H2AG [nucleoplasm]
(R-HSA-6782508)
Ack6-HIST1H2AG [nucleoplasm]
(R-HSA-4568595)
Me2aR30-HIST1H2AG [nucleoplasm]
(R-HSA-5244582)
MeR30-HIST1H2AG [nucleoplasm]
(R-HSA-5244560)
Me2aR4-HIST1H2AG [nucleoplasm]
(R-HSA-5244587)
MeR4-HIST1H2AG [nucleoplasm]
(R-HSA-5244623)
Me2aR12-HIST1H2AG [nucleoplasm]
(R-HSA-5229305)
MeR12-HIST1H2AG [nucleoplasm]
(R-HSA-5229206)
HIST1H2AG [nucleoplasm]
(R-HSA-212084)
Ack-HIST1H2AG [nucleoplasm]
(R-HSA-4551311)
0.527
2
UniProt:Q6ZS30 NBEL1
0.527
2
UniProt:Q99584 S10AD
0.527
2
UniProt:Q9Y4F1 FARP1
1
FARP1 [cytosol]
(R-HSA-9679578)
0.527
2
UniProt:O15530 PDPK1
3
p-S241-PDPK1 [cytosol]
(R-HSA-9860799)
PDPK1 [cytosol]
(R-HSA-202210)
PDPK1 [plasma membrane]
(R-HSA-61459)
0.527
2
UniProt:Q9ULK5 VANGL2
2
VANGL2 [plasma membrane]
(R-HSA-3965373)
pS5,S82,S84-VANGL2 [plasma membrane]
(R-HSA-4551547)
0.527
2
UniProt:Q8IXQ5 KLHL7
0.527
3
UniProt:Q96B77 TMEM186
1
TMEM186 [mitochondrial inner membrane]
(R-HSA-9708009)
0.527
2
UniProt:Q96QE5 TEFM
0.527
2
UniProt:P17152 TMEM11
1
TMEM11 [mitochondrial inner membrane]
(R-HSA-8949578)
0.527
2
UniProt:P21802 FGFR2
20
FGFR2 IIIa TM [extracellular region]
(R-HSA-8851703)
FGFR2 [plasma membrane]
(R-HSA-2023840)
FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane]
(R-HSA-8853137)
FGFR2(2-822)-CIT(927-2027) fusion [plasma membrane]
(R-HSA-8853154)
FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane]
(R-HSA-8853123)
FGFR2(22-767)-AHCYL1(108-530) fusion [plasma membrane]
(R-HSA-8853158)
FGFR2(22-767)-OFD1(38-1012) fusion [plasma membrane]
(R-HSA-8853150)
FGFR2(22-767)-CASP7(1-303) fusion [plasma membrane]
(R-HSA-8853153)
FGFR2(22-767)-AFF3(292-1226) fusion [plasma membrane]
(R-HSA-8853139)
FGFR2(22-767)-CCAR(51-923) fusion [plasma membrane]
(R-HSA-8853159)
FGFR2 N549H [plasma membrane]
(R-HSA-2033296)
FGFR2 N549K [plasma membrane]
(R-HSA-1637910)
FGFR2 K660N [plasma membrane]
(R-HSA-1637905)
FGFR2 K660M [plasma membrane]
(R-HSA-1637902)
FGFR2 K660E [plasma membrane]
(R-HSA-1637900)
FGFR2 S267P [plasma membrane]
(R-HSA-1637920)
FGFR2 L764Hfs*4 [plasma membrane]
(R-HSA-1637908)
FGFR2 W290C [plasma membrane]
(R-HSA-1637929)
p-6Y-FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane]
(R-HSA-8853134)
p-6Y-FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane]
(R-HSA-8853146)
0.527
2
UniProt:Q8WY07 SLC7A3
1
SLC7A3 [plasma membrane]
(R-HSA-375779)
0.527
2
UniProt:Q13268 DHRS2
0.527
3
UniProt:Q8IWU6 SULF1
0.527
2
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