HS3STs sulfate GlcN at C3 in heparan sulfate

Stable Identifier
Reaction [transition]
Homo sapiens
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Heparan sulfate 3-O-sulfotransferases (HS3ST2-6), associated with the Golgi membrane, transfer sulfate to the 3-OH position on glucosamine (GlcN) residues of heparan sulfate (HS) to form 3-O-sulfated HS (Shworak et al. 1999, Xia et al. 2002). HS3ST2-6 do not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.
Literature References
PubMed ID Title Journal Year
9346953 Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase

Liu, J, Rosenberg, RD, Schwartz, JJ, Fritze, LM, Zhang, L, Logeart, D, Shworak, NW

J Biol Chem 1997
9988767 Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cDNAs and identification of distinct genomic loci

Copeland, NG, Liu, J, Kobayashi, M, Rosenberg, RD, Jenkins, NA, Zhang, L, Petros, LM, Shworak, NW

J Biol Chem 1999
12138164 Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1

Liu, J, Malmstrom, A, Chen, J, Shukla, D, Tiwari, V, Ju, W, Li, JP, Xia, G

J Biol Chem 2002
Event Information
Catalyst Activity

[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity of HS3STs [Golgi membrane]

Orthologous Events
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