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HS(1)-AGRN [plasma membrane]
Stable Identifier
R-HSA-2076634
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
AGRN, Agrin, AGRIN_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
RSV-host interactions (Homo sapiens)
G protein binds CX3CR1 on host cell surface (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-AGRN [plasma membrane] (Homo sapiens)
sG binds to HSPGs (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-AGRN [plasma membrane] (Homo sapiens)
HSPGs:sG [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-AGRN [plasma membrane] (Homo sapiens)
Respiratory syncytial virus (RSV) attachment and entry (Homo sapiens)
G protein binds CX3CR1 on host cell surface (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-AGRN [plasma membrane] (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Early SARS-CoV-2 Infection Events (Homo sapiens)
Attachment and Entry (Homo sapiens)
Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-AGRN [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-AGRN [plasma membrane] (Homo sapiens)
Endocytosis of SARS-CoV-2 Virion (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-AGRN [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-AGRN [plasma membrane] (Homo sapiens)
FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-AGRN [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-AGRN [plasma membrane] (Homo sapiens)
Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-AGRN [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-AGRN [plasma membrane] (Homo sapiens)
TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-AGRN [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-AGRN [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
HS-GAG biosynthesis (Homo sapiens)
Some HSPGs are secreted to the plasma membrane (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-AGRN [plasma membrane] (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of fat-soluble vitamins (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
CR:atREs binds apoE and HSPG (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-AGRN [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-AGRN [plasma membrane] (Homo sapiens)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-AGRN [plasma membrane] (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-AGRN [plasma membrane] (Homo sapiens)
NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-AGRN [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-AGRN [plasma membrane] (Homo sapiens)
Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
CR:atREs binds apoE and HSPG (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-AGRN [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-AGRN [plasma membrane] (Homo sapiens)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-AGRN [plasma membrane] (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-AGRN [plasma membrane] (Homo sapiens)
NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-AGRN [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(1)-PGs [plasma membrane] (Homo sapiens)
HS(1)-AGRN [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00468 AGRN
Gene Names
AGRN, AGRIN
Chain
signal peptide:1-29, chain:30-2068, chain:30-1102, chain:1103-2068, chain:1103-1863, chain:1864-2068
Reference Genes
COSMIC (genes):AGRN O004686
dbSNP Gene:375790 O004686
ENSEMBL:ENSG00000188157 AGRN
Participates
as a member of
HS(1)-PGs [plasma membrane] (Homo sapiens)
Other forms of this molecule
HS(4)-AGRN [plasma membrane]
HS(6)-AGRN [plasma membrane]
HS(2)-AGRN [plasma membrane]
HS(3)-AGRN [plasma membrane]
HS(5)-AGRN [plasma membrane]
AGRN(30-2045) [extracellular region]
XylS-AGRN(30-2045) [Golgi lumen]
Gal-Xyl-AGRN [Golgi lumen]
AGRN(30-2045) [Golgi lumen]
Gal-Gal-Xyl-AGRN [Golgi lumen]
GlcA-Gal-Gal-Xyl-AGRN [Golgi lumen]
HS(3)-AGRN [Golgi lumen]
HS(4)-AGRN [Golgi lumen]
HS(2)-AGRN [Golgi lumen]
HS(1)-AGRN [Golgi lumen]
Heparan(4)-AGRN [Golgi lumen]
Heparan(3)-AGRN [Golgi lumen]
Heparan(2)-AGRN [Golgi lumen]
Heparan(1)-AGRN [Golgi lumen]
Heparan-AGRN [Golgi lumen]
HS(5)-AGRN [Golgi lumen]
HS(6)-AGRN [Golgi lumen]
HS(6)-AGRN [lysosomal lumen]
AGRN(30-2045) [lysosomal lumen]
Inferred To
Homologues of HS(1)-AGRN [plasma membrane]
(Caenorhabditis elegans)
AGRN [plasma membrane]
(Bos taurus)
AGRN [plasma membrane]
(Canis familiaris)
AGRN [plasma membrane]
(Sus scrofa)
SP2353 [plasma membrane]
(Drosophila melanogaster)
itx-1 [plasma membrane]
(Caenorhabditis elegans)
HS(1)-AGRN [plasma membrane]
(Caenorhabditis elegans)
HS(1)-AGRN [plasma membrane]
(Mus musculus)
HS(1)-AGRN [plasma membrane]
(Rattus norvegicus)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63652) at unknown position
Modification
beta-D-GlcA-(1->4)-alpha-D-GlcNS-(1->4)-beta-D-GlcA-(1->4)-alpha-D-GlcNS-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15530 PDPK1
3
p-S241-PDPK1 [cytosol]
(R-HSA-9860799)
PDPK1 [cytosol]
(R-HSA-202210)
PDPK1 [plasma membrane]
(R-HSA-61459)
0.527
2
UniProt:Q13438 OS9
1
OS9 [endoplasmic reticulum membrane]
(R-HSA-1022132)
0.527
3
UniProt:P02741 CRP
1
CRP(19-224) [extracellular region]
(R-HSA-976719)
0.527
3
UniProt:O15265 ATXN7
2
ATXN7 [nucleoplasm]
(R-HSA-8869458)
ATXN7 [cytosol]
(R-HSA-201591)
0.508
2
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