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HS(6)-GPC5 [plasma membrane]
Stable Identifier
R-HSA-2076676
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
GPC5, Glypican-5 component recommendedName: Secreted glypican-5 /component, GPC5_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
RSV-host interactions (Homo sapiens)
G protein binds CX3CR1 on host cell surface (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
sG binds to HSPGs (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
HSPGs:sG [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
Respiratory syncytial virus (RSV) attachment and entry (Homo sapiens)
G protein binds CX3CR1 on host cell surface (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Early SARS-CoV-2 Infection Events (Homo sapiens)
Attachment and Entry (Homo sapiens)
Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
Endocytosis of SARS-CoV-2 Virion (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
HS-GAG biosynthesis (Homo sapiens)
Some HSPGs are secreted to the plasma membrane (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
HS-GAG degradation (Homo sapiens)
HS-GAGs translocate to the lysosome for degradation (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Homo sapiens)
HPSE2:HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of fat-soluble vitamins (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
CR:atREs binds apoE and HSPG (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
CR:atREs binds apoE and HSPG (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC5 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P78333 GPC5
Gene Names
GPC5
Chain
signal peptide:1-24, chain:25-, chain:25-, propeptide:-572
Reference Genes
BioGPS Gene:2262 GPC5
COSMIC (genes):GPC5 GPC5
CTD Gene:2262 GPC5
dbSNP Gene:2262 GPC5
ENSEMBL:ENSG00000179399 GPC5
HGNC:4453 GPC5
KEGG:hsa:2262 GPC5
Monarch:2262 GPC5
NCBI Gene:2262 GPC5
OMIM:602446 GPC5
UCSC:P78333 GPC5
Reference Transcript
RefSeq:NM_004466.5 GPC5
Other Identifiers
11729726_at
11729727_at
16775785
207174_PM_at
207174_at
2262
3496410
3496411
3496412
3496413
3496417
3496445
3496451
3496452
3496454
3496455
3496469
3496480
3496528
3496529
3496530
3496531
3496533
3496534
3496535
3585647
3585660
3613117
3615141
3657682
3658096
36788_at
3688649
3688731
4038869
4039260
7969596
A_14_P100211
A_14_P110012
A_23_P112874
A_33_P3368855
GE58336
GO:0005515
GO:0005576
GO:0005794
GO:0005796
GO:0005886
GO:0009966
GO:0009986
GO:0016020
GO:0016477
GO:0030312
GO:0031012
GO:0043202
GO:0043226
GO:0048870
GO:0062023
GO:0090263
GO:0098552
GO:1905475
HMNXSV003015846
ILMN_1688886
PH_hs_0026289
PH_hs_0028978
TC13000323.hg
U66033_at
g5360214_3p_at
Participates
as a member of
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
Other forms of this molecule
HS(4)-GPC5 [plasma membrane]
HS(2)-GPC5 [plasma membrane]
HS(1)-GPC5 [plasma membrane]
HS(3)-GPC5 [plasma membrane]
HS(5)-GPC5 [plasma membrane]
XylS-GPC5(25-?) [Golgi lumen]
Gal-Xyl-GPC5 [Golgi lumen]
GPC5(25-?) [Golgi lumen]
Gal-Gal-Xyl-GPC5 [Golgi lumen]
GlcA-Gal-Gal-Xyl-GPC5 [Golgi lumen]
HS(3)-GPC5 [Golgi lumen]
HS(4)-GPC5 [Golgi lumen]
HS(2)-GPC5 [Golgi lumen]
HS(1)-GPC5 [Golgi lumen]
Heparan(4)-GPC5 [Golgi lumen]
Heparan(3)-GPC5 [Golgi lumen]
Heparan(2)-GPC5 [Golgi lumen]
Heparan(1)-GPC5 [Golgi lumen]
Heparan-GPC5 [Golgi lumen]
HS(5)-GPC5 [Golgi lumen]
HS(6)-GPC5 [Golgi lumen]
HS(6)-GPC5 [lysosomal lumen]
GPC5(25-?) [lysosomal lumen]
GPI-GPC5 [plasma membrane]
GPI-cleaved GPC5 [extracellular region]
Inferred To
GPC5 [plasma membrane]
(Bos taurus)
GPC5 [plasma membrane]
(Canis familiaris)
GPC5 [plasma membrane]
(Sus scrofa)
gpc5a [plasma membrane]
(Danio rerio)
dally [plasma membrane]
(Drosophila melanogaster)
HS(6)-GPC5 [plasma membrane]
(Gallus gallus)
Gpc5 [plasma membrane]
(Mus musculus)
Gpc5 [plasma membrane]
(Rattus norvegicus)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63666) at unknown position
Modification
beta-D-IdoA-(1->4)-alpha-D-GlcNS6S-(1->4)-beta-D-IdoA2S-(1->4)-alpha-D-GlcNS3S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_004457.1
OpenTargets
ENSG00000179399
ENSEMBL
ENSP00000366267
,
ENST00000377067
HPA
ENSG00000179399-GPC5
PRO
P78333
Pharos - Targets
P78333
GlyGen
P78333
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96IK1-2 Q96IK12
0.556
3
UniProt:Q8TD91-2 MAGEC3
0.556
3
UniProt:Q6P1L5 F117B
0.556
3
UniProt:Q8N488 RYBP
1
RYBP [nucleoplasm]
(R-HSA-8937975)
0.556
3
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