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HS(6)-GPC4 [plasma membrane]
Stable Identifier
R-HSA-2076677
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
GPC4, Glypican-4, GPC4_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
RSV-host interactions (Homo sapiens)
G protein binds CX3CR1 on host cell surface (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
sG binds to HSPGs (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
HSPGs:sG [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
Respiratory syncytial virus (RSV) attachment and entry (Homo sapiens)
G protein binds CX3CR1 on host cell surface (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Early SARS-CoV-2 Infection Events (Homo sapiens)
Attachment and Entry (Homo sapiens)
Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
Endocytosis of SARS-CoV-2 Virion (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
HS-GAG biosynthesis (Homo sapiens)
Some HSPGs are secreted to the plasma membrane (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
HS-GAG degradation (Homo sapiens)
HS-GAGs translocate to the lysosome for degradation (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
Heparanase 2 (HPSE2) binds heparan sulfate proteoglycans (Homo sapiens)
HPSE2:HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of fat-soluble vitamins (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
CR:atREs binds apoE and HSPG (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
CR:atREs binds apoE and HSPG (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
HS(6)-GPC4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75487 GPC4
Gene Names
GPC4, UNQ474/PRO937
Chain
signal peptide:1-18, chain:19-529, chain:19-, propeptide:530-556
Reference Genes
BioGPS Gene:2239 GPC4
COSMIC (genes):GPC4 GPC4
CTD Gene:2239 GPC4
dbSNP Gene:2239 GPC4
ENSEMBL:ENSG00000076716 GPC4
ENSEMBL_homo_sapiens_GENE:ENSG00000076716.9 GPC4
HGNC:4452 GPC4
KEGG Gene (Homo sapiens):2239 GPC4
Monarch:2239 GPC4
NCBI Gene:2239 GPC4
OMIM:300168 GPC4
UCSC:O75487 GPC4
Reference Transcript
RefSeq:NM_001448.2 GPC4
Other Identifiers
11727403_at
11727404_a_at
11758979_at
17114272
204983_PM_s_at
204983_s_at
204984_PM_at
204984_at
2239
36508_at
4022380
4022381
4022382
4022383
4022384
4022385
4022386
4022387
4022389
4022390
4022391
4022392
4022393
4022396
4022405
4022411
4022438
4022439
52756_at
8175217
A_23_P435407
GE54232
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005764
GO:0005773
GO:0005794
GO:0005796
GO:0005886
GO:0007155
GO:0009897
GO:0009966
GO:0009986
GO:0015026
GO:0016020
GO:0016055
GO:0016477
GO:0023052
GO:0030312
GO:0031012
GO:0034330
GO:0043202
GO:0043226
GO:0045202
GO:0048856
GO:0048870
GO:0060089
GO:0062023
GO:0070062
GO:0098552
GO:0098696
GO:0098978
GO:0099560
GO:1905606
HMNXSV003012893
ILMN_1789502
PH_hs_0003752
TC0X001376.hg
g3420276_3p_a_at
g4504082_3p_at
Participates
as a member of
HS/HPIN-PGs [plasma membrane] (Homo sapiens)
Other forms of this molecule
GPC4 [lysosomal lumen]
HS(6)-GPC4 [lysosomal lumen]
HS(1)-GPC4 [Golgi lumen]
HS(2)-GPC4 [Golgi lumen]
HS(3)-GPC4 [Golgi lumen]
HS(4)-GPC4 [Golgi lumen]
HS(6)-GPC4 [Golgi lumen]
HS(5)-GPC4 [Golgi lumen]
Heparan-GPC4 [Golgi lumen]
Heparan(1)-GPC4 [Golgi lumen]
Heparan(2)-GPC4 [Golgi lumen]
Heparan(4)-GPC4 [Golgi lumen]
HS(4)-GPC4 [plasma membrane]
HS(2)-GPC4 [plasma membrane]
HS(1)-GPC4 [plasma membrane]
HS(3)-GPC4 [plasma membrane]
HS(5)-GPC4 [plasma membrane]
Gal-Gal-Xyl-GPC4 [Golgi lumen]
GlcA-Gal-Gal-Xyl-GPC4 [Golgi lumen]
Gal-Xyl-GPC4 [Golgi lumen]
XylS-GPC4 [Golgi lumen]
GPC4 [Golgi lumen]
Heparan(3)-GPC4 [Golgi lumen]
Inferred To
Gpc4 [plasma membrane]
(Mus musculus)
Gpc4 [plasma membrane]
(Rattus norvegicus)
HS(6)-GPC4 [plasma membrane]
(Gallus gallus)
GPC4 [plasma membrane]
(Bos taurus)
GPC4 [plasma membrane]
(Canis familiaris)
GPC4 [plasma membrane]
(Sus scrofa)
gpc4 [plasma membrane]
(Danio rerio)
gpc4 [plasma membrane]
(Xenopus tropicalis)
gpn-1 [plasma membrane]
(Caenorhabditis elegans)
dlp [plasma membrane]
(Drosophila melanogaster)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63666) at unknown position
Modification
beta-D-IdoA-(1->4)-alpha-D-GlcNS6S-(1->4)-beta-D-IdoA2S-(1->4)-alpha-D-GlcNS3S-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_001439.2
OpenTargets
ENSG00000076716
HPA
ENSG00000076716-GPC4
GeneCards
O75487
Ensembl
ENSG00000076716
,
ENST00000370828
,
ENSP00000359864
PRO
O75487
Pharos - Targets
O75487
Orphanet
17714
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:O15530 PDPK1
3
p-S241-PDPK1 [cytosol]
(R-HSA-9860799)
PDPK1 [cytosol]
(R-HSA-202210)
PDPK1 [plasma membrane]
(R-HSA-61459)
0.527
2
UniProt:P32249 GPR183
1
GPR183 [plasma membrane]
(R-HSA-8851676)
0.527
3
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