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HS(2)-SDC3 [plasma membrane]
Stable Identifier
R-HSA-2076692
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
SDC3, Syndecan-3, SDC3_HUMAN
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
RSV-host interactions (Homo sapiens)
G protein binds CX3CR1 on host cell surface (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
sG binds to HSPGs (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
HSPGs:sG [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
Respiratory syncytial virus (RSV) attachment and entry (Homo sapiens)
G protein binds CX3CR1 on host cell surface (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Early SARS-CoV-2 Infection Events (Homo sapiens)
Attachment and Entry (Homo sapiens)
Direct Host Cell Membrane Membrane Fusion and Release of SARS-CoV-2 Nucleocapsid (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
Endocytosis of SARS-CoV-2 Virion (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
FURIN Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
Spike glycoprotein of SARS-CoV-2 binds ACE2 on host cell (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
TMPRSS2 Mediated SARS-CoV-2 Spike Protein Cleavage and Endocytosis (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
S3:M:E:encapsidated SARS-CoV-2 genomic RNA: 7a:O-glycosyl 3a tetramer:glycosylated-ACE2:HSPGs [extracellular region] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
Syndecan interactions (Homo sapiens)
Syndecans 1, 2, 4, (3) bind FGF2 (Homo sapiens)
SDC1, 2, 4, (3) [plasma membrane] (Homo sapiens)
Syndecan-3 [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
SDC1,2,4,(3):FGF2 [plasma membrane] (Homo sapiens)
SDC1, 2, 4, (3) [plasma membrane] (Homo sapiens)
Syndecan-3 [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
TNC binds Syndecan-3 (Homo sapiens)
Syndecan-3 [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
TNC:Syndecan-3 [plasma membrane] (Homo sapiens)
Syndecan-3 [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
PSGs bind proteoglycans and TGF-beta1 (Homo sapiens)
PSGs:Proteoglycan,TGFB1 [plasma membrane] (Homo sapiens)
Proteoglycans,TGFB1 [plasma membrane] (Homo sapiens)
Syndecans1-4 [plasma membrane] (Homo sapiens)
Syndecan-3 [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
Proteoglycans,TGFB1 [plasma membrane] (Homo sapiens)
Syndecans1-4 [plasma membrane] (Homo sapiens)
Syndecan-3 [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Heparan sulfate/heparin (HS-GAG) metabolism (Homo sapiens)
HS-GAG biosynthesis (Homo sapiens)
Some HSPGs are secreted to the plasma membrane (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of fat-soluble vitamins (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
CR:atREs binds apoE and HSPG (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
CR:atREs binds apoE and HSPG (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
CR:atREs:HSPG:apoE [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
NREH hydrolyses atREs (HSPG:apoE) to atROL and FAs (Homo sapiens)
CR:atREs:HSPG:apoE [early endosome] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
HSPGs [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
HS(2)-SDC3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75056 SDC3
Gene Names
SDC3, KIAA0468
Chain
chain:1-442
Reference Genes
BioGPS Gene:9672 SDC3
COSMIC (genes):SDC3 SDC3
CTD Gene:9672 SDC3
dbSNP Gene:9672 SDC3
ENSEMBL:ENSG00000162512 SDC3
ENSEMBL_homo_sapiens_GENE:ENSG00000162512.16 SDC3
HGNC:10660 SDC3
KEGG Gene (Homo sapiens):9672 SDC3
Monarch:9672 SDC3
NCBI Gene:9672 SDC3
OMIM:186357 SDC3
UCSC:O75056 SDC3
Reference Transcript
RefSeq:NM_014654.3 SDC3
Other Identifiers
11739276_at
11739277_at
1554864_PM_a_at
1554864_a_at
202898_PM_at
202898_at
2404210
2404211
2404212
2404213
2404214
2404215
2404216
2404217
2404218
2404219
2404220
2404221
2404227
2404228
2404229
2404230
2404231
2404234
2404248
2404249
32092_at
7914282
9672
A_23_P74887
A_33_P3241884
GE53205
GO:0005515
GO:0005764
GO:0005773
GO:0005794
GO:0005796
GO:0005886
GO:0009986
GO:0016020
GO:0016477
GO:0030312
GO:0031012
GO:0042802
GO:0043202
GO:0043226
GO:0044393
GO:0048870
GO:0062023
HMNXSV003053205
Hs2.158287.2.S1_3p_s_at
ILMN_1753523
ILMN_1802418
PH_hs_0009580
TC01002444.hg
g7662137_3p_at
Participates
as a member of
Syndecan-3 [plasma membrane] (Homo sapiens)
HS(2)-PGs [plasma membrane] (Homo sapiens)
Other forms of this molecule
SDC3 [lysosomal lumen]
HS(6)-SDC3 [lysosomal lumen]
HS(1)-SDC3 [Golgi lumen]
HS(2)-SDC3 [Golgi lumen]
HS(3)-SDC3 [Golgi lumen]
HS(4)-SDC3 [Golgi lumen]
HS(6)-SDC3 [Golgi lumen]
HS(5)-SDC3 [Golgi lumen]
Heparan-SDC3 [Golgi lumen]
Heparan(1)-SDC3 [Golgi lumen]
Heparan(2)-SDC3 [Golgi lumen]
HS(4)-SDC3 [plasma membrane]
HS(6)-SDC3 [plasma membrane]
HS(1)-SDC3 [plasma membrane]
HS(3)-SDC3 [plasma membrane]
HS(5)-SDC3 [plasma membrane]
Gal-Gal-Xyl-SDC3 [Golgi lumen]
GlcA-Gal-Gal-Xyl-SDC3 [Golgi lumen]
Gal-Xyl-SDC3 [Golgi lumen]
XylS-SDC3 [Golgi lumen]
SDC3 [Golgi lumen]
Heparan(3)-SDC3 [Golgi lumen]
Heparan(4)-SDC3 [Golgi lumen]
Inferred To
SDC3 [plasma membrane]
(Canis familiaris)
SDC3 [plasma membrane]
(Sus scrofa)
sdn-1 [plasma membrane]
(Caenorhabditis elegans)
HS(2)-SDC3 [plasma membrane]
(Bos taurus)
HS(2)-SDC3 [plasma membrane]
(Gallus gallus)
Sdc3 [plasma membrane]
(Mus musculus)
Sdc3 [plasma membrane]
(Rattus norvegicus)
Sdc [plasma membrane]
(Drosophila melanogaster)
Modified Residues
Name
O-xylosyl-L-serine (ChEBI:63653) at unknown position
Modification
beta-D-GlcA-(1->4)-alpha-D-GlcNS-(1->4)-beta-D-IdoA-(1->4)-alpha-D-GlcNS-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl-yl group
PsiMod Name
O-xylosyl-L-serine
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O3-xylosylserine.
Cross References
RefSeq
NP_055469.3
OpenTargets
ENSG00000162512
HPA
ENSG00000162512-SDC3
GeneCards
O75056
Ensembl
ENSP00000344468
,
ENST00000339394
,
ENSG00000162512
PRO
O75056
Pharos - Targets
O75056
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