TRPC1 translocates calcium from the extracellular region to the cytosol

Stable Identifier
Reaction [transition]
Homo sapiens
Calcium Influx via TRPC1
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TRPC1 forms a channel that transports Ca2+ across the plasma membrane. TRPC1 is gated by STIM1 (Ong et al. 2007).

Literature References
PubMed ID Title Journal Year
18995841 STIM1 gates TRPC channels, but not Orai1, by electrostatic interaction

Yuan, JP, Muallem, S, Kim, MS, Huang, GN, Choi, YJ, Zeng, W, Worley, PF

Mol Cell 2008
17486119 STIM1 heteromultimerizes TRPC channels to determine their function as store-operated channels

Yuan, JP, Muallem, S, Huang, GN, Zeng, W, Worley, PF

Nat Cell Biol 2007
22210847 The Ca2+ Sensor STIM1 is Necessary and Sufficient for the Store-Operated Ca2+ Entry Function of TRPCs in Endothelial Cells

Freichel, M, Tiruppathi, C, Yuan, JP, Malik, AB, Vogel, SM, Sundivakkam, PC, Flockerzi, V, Singh, V

Mol Pharmacol 2011
17224452 Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components

Gwack, Y, Ong, HL, Bandyopadhyay, BC, Ambudkar, IS, Srikanth, S, Liu, X, Singh, BB, Pani, B, Paria, BC, Gill, DL, Soboloff, J, Cheng, KT

J Biol Chem 2007
Catalyst Activity

cation channel activity of STIM1:TRPC1 [plasma membrane]

Orthologous Events
Cross References
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