IKBA is phosphorylated by Phospho IKKB kinase

Stable Identifier
R-HSA-209087
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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IKBA is phosphorylated by Phospho IKKB kinase
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Human IKBA, orthologue of Drosophila Cactus (CACT), is phosphorylated by activated IKKB kinase at residues Ser32 and Ser36.

Literature References
PubMed ID Title Journal Year
9346484 IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation

Bennett, BL, Rao, A, Barbosa, M, Shevchenko, A, Young, DB, Mann, M, Manning, A, Li, J, Mercurio, F, Murray, BW, Zhu, H

Science 1997
12791687 Differential phosphorylation of the signal-responsive domain of I kappa B alpha and I kappa B beta by I kappa B kinases

Wu, C, Ghosh, S

J Biol Chem 2003
Participants
Input
Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-S177,S181-IKBKB [cytosol]

Physical Entity
p-S177,S181-IKBKB [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
IKBA is phosphorylated by Phospho IKKB kinase (Bos taurus)
IKBA is phosphorylated by Phospho IKKB kinase (Canis familiaris)
IKBA is phosphorylated by Phospho IKKB kinase (Danio rerio)
IKBA is phosphorylated by Phospho IKKB kinase (Drosophila melanogaster)
IKBA is phosphorylated by Phospho IKKB kinase (Gallus gallus)
IKBA is phosphorylated by Phospho IKKB kinase (Mus musculus)
IKBA is phosphorylated by Phospho IKKB kinase (Rattus norvegicus)
IKBA is phosphorylated by Phospho IKKB kinase (Sus scrofa)
IKBA is phosphorylated by Phospho IKKB kinase (Xenopus tropicalis)
Authored
Ray, KP  (2010-05-17)
Reviewed
Pinteaux, E  (2010-05-17)
Created
Williams, MG  (2007-07-12)
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