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DIT and MIT combine to form triiodothyronine
Stable Identifier
R-HSA-209925
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Metabolism of amine-derived hormones (Homo sapiens)
Thyroxine biosynthesis (Homo sapiens)
DIT and MIT combine to form triiodothyronine (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Mono- and di-iodinated tyrosine can combine to form tri-iodothyronine (T3). The hormone thyrotropin can stimulate the production of T3 and T4.
Literature References
PubMed ID
Title
Journal
Year
67547
Biosynthesis of thyroid hormone: basic and clinical aspects
Niepomniszcze, H
,
Degroot, LJ
Metabolism
1977
Participants
Input
DIT [extracellular region]
MIT [extracellular region]
Output
L-Ala [extracellular region]
T3 [extracellular region]
Participates
as an event of
Thyroxine biosynthesis (Homo sapiens)
Catalyst Activity
peroxidase activity of TPO [plasma membrane]
Physical Entity
TPO [plasma membrane]
(Homo sapiens)
Activity
peroxidase activity (GO:0004601)
This event is regulated
Positively by
Regulator
Thyrotropin [extracellular region]
(Homo sapiens)
Orthologous Events
DIT and MIT combine to form triiodothyronine (Bos taurus)
DIT and MIT combine to form triiodothyronine (Caenorhabditis elegans)
DIT and MIT combine to form triiodothyronine (Canis familiaris)
DIT and MIT combine to form triiodothyronine (Dictyostelium discoideum)
DIT and MIT combine to form triiodothyronine (Drosophila melanogaster)
DIT and MIT combine to form triiodothyronine (Gallus gallus)
DIT and MIT combine to form triiodothyronine (Mus musculus)
DIT and MIT combine to form triiodothyronine (Rattus norvegicus)
DIT and MIT combine to form triiodothyronine (Sus scrofa)
Authored
Jassal, B (2008-10-01)
Reviewed
D'Eustachio, P (2008-05-28)
Created
Jassal, B (2008-01-08)
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