Reactome | p-Y663,Y686-PECAM1(27-?) [plasma membrane]

p-Y663,Y686-PECAM1(27-?) [plasma membrane]

Stable Identifier

R-HSA-210007

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

phosphorylated PECAM-1, p-CD31 antigen

Icon

Locations in the PathwayBrowser for interactor UniProt:Q96BD6 SPSB1

Expand all

External Reference Information

External Reference

UniProt:P16284 PECAM1

Gene Names

PECAM1

Chain

signal peptide:1-27, chain:28-738

Reference Genes

BioGPS Gene:5175 PECAM1

COSMIC (genes):PECAM1 PECAM1

CTD Gene:5175 PECAM1

dbSNP Gene:5175 PECAM1

ENSEMBL:ENSG00000261371 PECAM1

HGNC:8823 PECAM1

KEGG:hsa:5175 PECAM1

Monarch:5175 PECAM1

NCBI Gene:5175 PECAM1

OMIM:173445 PECAM1

UCSC:P16284 PECAM1

Reference Transcript

Other Identifiers

11720644_a_at

11757545_x_at

1558397_PM_at

1558397_at

17125960

208981_PM_at

208981_at

208982_PM_at

208982_at

208983_PM_s_at

208983_s_at

268_at

37398_at

3766798

3766799

3766800

3766801

3766802

3766803

3766804

3766805

3766806

3766807

3766819

3766824

3766825

3766828

3766829

3766830

3766831

3766833

3766834

3766835

3766837

3766838

3766839

3766840

3766841

3766842

3766847

3766848

3766849

3766850

3766851

3766852

3766855

3766858

47482_at

5175

8017599

90067_s_at

A_33_P3229402

A_33_P3405213

GE60495

GE778494

GO:0001934

GO:0002376

GO:0004888

GO:0005515

GO:0005615

GO:0005886

GO:0005911

GO:0006909

GO:0006955

GO:0007155

GO:0007156

GO:0007159

GO:0007165

GO:0007166

GO:0008037

GO:0009897

GO:0016192

GO:0030335

GO:0030667

GO:0031092

GO:0032991

GO:0034330

GO:0035633

GO:0035696

GO:0042803

GO:0043226

GO:0045121

GO:0048856

GO:0048870

GO:0050731

GO:0050904

GO:0060089

GO:0061028

GO:0070062

GO:0070161

GO:0070830

GO:0072011

GO:0072672

GO:0098609

GO:0098742

GO:0150107

HMNXSV003027445

HMNXSV003057981

Hs.78146.0.S2_3p_at

Hs.78146.0.S3_3p_at

Hs2.376675.1.S1_3p_at

ILMN_1689518

L34657_at

PH_hs_0004514

PH_hs_0018325

TC17001798.hg

TC17002747.hg

X96849_at

g187239_3p_a_at

Participates

as a component of

as an input of

as an output of

PECAM1 is phosphorylated (Homo sapiens)

Other forms of this molecule

PECAM1 [plasma membrane]

PECAM1 [secretory granule membrane]

p-Y713-PECAM1 [plasma membrane]

PECAM1 [platelet alpha granule membrane]

Inferred To

phospho-p-Y663,Y686-PECAM1(27-?) [plasma membrane] (Gallus gallus)

phospho-PECAM1 [plasma membrane] (Bos taurus)

phospho-PECAM1 [plasma membrane] (Canis familiaris)

phospho-PECAM1 [plasma membrane] (Sus scrofa)

phospho-Pecam1 [plasma membrane] (Mus musculus)

phospho-Pecam1 [plasma membrane] (Rattus norvegicus)

Homologues of p-Y663,Y686-PECAM1(27-?) [plasma membrane] (Sus scrofa)

Modified Residues

Name

O4'-phospho-L-tyrosine at 663

Coordinate

663

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 686

Coordinate

686

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_011523192.1, NP_000433.4, XP_016880229.1, XP_005276937.1, XP_005276938.1, XP_005276939.1, XP_016880227.1, XP_011523191.1, XP_016880228.1

OpenTargets

ENSG00000261371

ENSEMBL

ENSP00000457421, ENST00000563924

HPA

ENSG00000261371-PECAM1

PRO

P16284

Pharos - Targets

P16284

GlyGen

P16284

PDB

5GNI, 5C14, 2KY5

Interactors (83)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q06124 PTPN11	4	p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573) PTPN11 [cytosol] (R-HSA-162563) PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y542-PTPN11 [cytosol] (R-HSA-1369081)	0.69	7
UniProt:P09382 LGALS1	2	LGALS1 [endoplasmic reticulum lumen] (R-HSA-8956711) p-LGALS1 [endoplasmic reticulum lumen] (R-HSA-8957003)	0.675	4
UniProt:P14923 JUP	6	JUP [plasma membrane] (R-HSA-437260) JUP [specific granule lumen] (R-HSA-6799534) JUP [extracellular region] (R-HSA-6806309) JUP [ficolin-1-rich granule lumen] (R-HSA-6801028) JUP [cornified envelope] (R-HSA-8847739) JUP [cytosol] (R-HSA-201598)	0.61	7
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y419-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.59	3
UniProt:O75175 CNOT3	1	CNOT3 [cytosol] (R-HSA-429872)	0.556	3
UniProt:Q96BD6 SPSB1	1	SPSB1 [cytosol] (R-HSA-976024)	0.556	3
IntAct:EBI-25881637 CCSB			0.556	3
UniProt:Q9NX09 DDIT4	1	DDIT4 [cytosol] (R-HSA-5632374)	0.556	3
UniProt:Q8NCS7 SLC44A5	1	SLC44A5 [plasma membrane] (R-HSA-444459)	0.556	3
UniProt:Q6ZSB9 ZBT49			0.556	3
UniProt:O15273 TCAP	1	TCAP [cytosol] (R-HSA-390571)	0.556	3
UniProt:Q08AE8 SPIR1			0.556	3
IntAct:EBI-25861394 CCSB			0.556	3
UniProt:Q6ZU52 K0408			0.556	3
UniProt:Q9GZQ6 NPFFR1	1	NPFFR1 [plasma membrane] (R-HSA-389429)	0.556	3
UniProt:Q9UJD0 RIMS3			0.556	3
UniProt:P17024 ZNF20	1	ZNF20 [nucleoplasm] (R-HSA-975024)	0.556	3
IntAct:EBI-25881483 CCSB			0.556	3
UniProt:Q9H270 VPS11	1	VPS11 [endosome membrane] (R-HSA-2197802)	0.556	3
UniProt:P46977 STT3A	1	STT3A [endoplasmic reticulum membrane] (R-HSA-265023)	0.556	3
UniProt:Q08AM6 VAC14	3	VAC14 [Golgi membrane] (R-HSA-1806235) VAC14 [early endosome membrane] (R-HSA-1806207) VAC14 [late endosome membrane] (R-HSA-1806219)	0.556	3
UniProt:Q8N302-2 Q8N3022			0.556	3
UniProt:Q96LI6 HSFY1			0.556	3
UniProt:Q9UMX3 BOK			0.556	3
UniProt:Q8TAB5 CA216			0.556	3
UniProt:P49184 DNASE1L1	2	DNASE1L1 [extracellular region] (R-HSA-6806320) DNASE1L1 [specific granule lumen] (R-HSA-6799554)	0.556	3
UniProt:Q6ZQX7-4 Q6ZQX74			0.556	3
UniProt:Q8WUY3 PRUN2			0.556	3
UniProt:Q96I25 RBM17	1	RBM17 [nucleoplasm] (R-HSA-8865891)	0.556	3
UniProt:Q9Y3D0 CIAO2B	1	FAM96B [cytosol] (R-HSA-2161124)	0.556	3
UniProt:P12757 SKIL	1	SKIL [nucleoplasm] (R-HSA-2186596)	0.556	3
UniProt:Q6NXG1 ESRP1	3	ESRP1(1-606)-RAF1(227-648) fusion [cytosol] (R-HSA-6802312) ESRP1(1-606)-p-RAF1(227-648) fusion [cytosol] (R-HSA-6802523) ESRP1 [nucleoplasm] (R-HSA-6803472)	0.556	3
UniProt:Q9P286 PAK5	2	PAK5 [cytosol] (R-HSA-428459) PAK7 [plasma membrane] (R-HSA-211555)	0.556	3
UniProt:Q9BQ29 Q9BQ29			0.556	3
UniProt:Q8IUW3 SPA2L			0.556	3
UniProt:Q6DHV7-2 Q6DHV72			0.556	3
UniProt:Q96G97-4 BSCL2			0.556	3
UniProt:Q96JJ7-2 Q96JJ72			0.556	3
UniProt:P61966-2 AP1S1			0.556	3
UniProt:P61513 RPL37A	1	RPL37A [cytosol] (R-HSA-72468)	0.556	3
UniProt:Q96GL9 F163A			0.556	3
UniProt:Q14847-2 LASP1			0.556	3
UniProt:O77932 DXO			0.556	3
UniProt:P19544-6 WT1			0.556	3
UniProt:O75874 IDH1	10	IDH1 [cytosol] (R-HSA-389549) IDH1 [peroxisomal matrix] (R-HSA-389546) IDH1 [secretory granule lumen] (R-HSA-6800980) IDH1 [extracellular region] (R-HSA-6806433) IDH1 [tertiary granule lumen] (R-HSA-6800163) IDH1 [ficolin-1-rich granule lumen] (R-HSA-6800977) IDH1 R132C mutant [cytosol] (R-HSA-880031) IDH1 R132S mutant [cytosol] (R-HSA-880048) IDH1 R132L mutant [cytosol] (R-HSA-880000) IDH1 R132H mutant [cytosol] (R-HSA-880015)	0.556	3
UniProt:Q96PV4 PNMA5			0.556	3
UniProt:O15287 FANCG	2	FANCG [nucleoplasm] (R-HSA-419532) FANCG [cytosol] (R-HSA-420788)	0.556	3
UniProt:Q12824 SMARCB1	1	SMARCB1 [nucleoplasm] (R-HSA-389261)	0.556	3
UniProt:Q8NC51 SERB1			0.556	3
UniProt:Q96E93 KLRG1	1	KLRG1 [plasma membrane] (R-HSA-198006)	0.556	3
UniProt:Q6IAA8 LAMTOR1	5	LAMTOR1 [lysosomal membrane] (R-HSA-5653582) LAMTOR1 [ficolin-1-rich granule membrane] (R-HSA-6801003) LAMTOR1 [plasma membrane] (R-HSA-6806270) LAMTOR1 [azurophil granule membrane] (R-HSA-6799633) LAMTOR1 [specific granule membrane] (R-HSA-6799631)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:P54819 AK2	1	AK2 [mitochondrial intermembrane space] (R-HSA-57822)	0.556	3
UniProt:Q9HB63 NTN4	1	NTN4 [plasma membrane] (R-HSA-561258)	0.556	3
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591)	0.556	3
UniProt:P26651 ZFP36	2	p-S60,S186-ZFP36 [cytosol] (R-HSA-450496) ZFP36 [cytosol] (R-HSA-450562)	0.556	3
UniProt:Q13405 MRPL49	1	MRPL49 [mitochondrial inner membrane] (R-HSA-5368260)	0.556	3
UniProt:Q0VD86 INCA1			0.556	3
IntAct:EBI-25833683 CCSB			0.556	3
UniProt:Q8TBJ4 PLPPR1	1	LPPR1 [plasma membrane] (R-HSA-6797625)	0.556	3
UniProt:Q13428-5 TCOF1			0.556	3
UniProt:Q9UQM7 CAMK2A	6	p-T286-CAMK2A [cytosol] (R-HSA-445368) CAMK2A [cytosol] (R-HSA-4332329) p-T286-CAMK2A [endocytic vesicle membrane] (R-HSA-416999) p-T286,T305,T306-CAMK2A [cytosol] (R-HSA-4332334) p-T286-CAMK2A [nucleoplasm] (R-HSA-444797) p-T286-CAMK2A [plasma membrane] (R-HSA-432796)	0.556	3
UniProt:Q7Z614-3 SNX20			0.556	3
UniProt:I6L9F6 I6L9F6			0.556	3
UniProt:P15923-3 TCF3			0.556	3
UniProt:Q5JSH3 WDR44			0.556	3
UniProt:Q7Z403 TMC6	3	TMC6 [tertiary granule membrane] (R-HSA-6800920) TMC6 [plasma membrane] (R-HSA-6800446) TMC6 [specific granule membrane] (R-HSA-6799712)	0.556	3
UniProt:Q99944 EGFL8			0.556	3
UniProt:Q99504 EYA3	2	p-EYA3 [nucleoplasm] (R-HSA-5683979) EYA3 [nucleoplasm] (R-HSA-5683622)	0.556	3
UniProt:Q4G1C9-2 Q4G1C92			0.556	3
UniProt:Q9NS73-5 MBIP			0.556	3
UniProt:Q6XD76 ASCL4			0.556	3
UniProt:Q9H7C4 SYNCI			0.556	3
UniProt:Q99619 SPSB2	1	SPSB2 [cytosol] (R-HSA-976048)	0.556	3
UniProt:Q96HB5 CC120			0.556	3
UniProt:Q16549 PCSK7			0.556	3
UniProt:O60506-4 SYNCRIP			0.556	3
UniProt:Q14728 MFS10			0.556	3
UniProt:Q5T1C6 THEM4	3	THEM4 [mitochondrial matrix] (R-HSA-162408) THEM4 [cytosol] (R-HSA-6809345) THEM4 [plasma membrane] (R-HSA-199437)	0.556	3
UniProt:Q5VYS8-5 TUT7			0.556	3
UniProt:Q8NBT0 POC1A			0.556	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.483	3
UniProt:P29350 PTPN6	5	PTPN6 [tertiary granule lumen] (R-HSA-6800952) PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [specific granule lumen] (R-HSA-6799641) PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [cytosol] (R-HSA-197938)	0.462	4

Cite Us!