Reactome | p-Y663,Y686-PECAM1(27-?) [plasma membrane]

p-Y663,Y686-PECAM1(27-?) [plasma membrane]

Stable Identifier

R-HSA-210007

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

phosphorylated PECAM-1, p-CD31 antigen

Icon

Locations in the PathwayBrowser for interactor UniProt:Q99619 SPSB2

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External Reference Information

External Reference

UniProt:P16284 PECAM1

Gene Names

PECAM1

Chain

signal peptide:1-27, chain:28-738

Reference Genes

BioGPS Gene:5175 PECAM1

COSMIC (genes):PECAM1 PECAM1

CTD Gene:5175 PECAM1

dbSNP Gene:5175 PECAM1

ENSEMBL:ENSG00000261371 PECAM1

ENSEMBL_homo_sapiens_GENE:ENSG00000261371.6 PECAM1

HGNC:8823 PECAM1

KEGG Gene (Homo sapiens):5175 PECAM1

Monarch:5175 PECAM1

NCBI Gene:5175 PECAM1

OMIM:173445 PECAM1

Reference Transcript

Other Identifiers

11720644_a_at

11757545_x_at

1558397_PM_at

1558397_at

17125960

208981_PM_at

208981_at

208982_PM_at

208982_at

208983_PM_s_at

208983_s_at

268_at

37398_at

3766798

3766799

3766800

3766801

3766802

3766803

3766804

3766805

3766806

3766807

3766819

3766824

3766825

3766828

3766829

3766830

3766831

3766833

3766834

3766835

3766838

3766841

3766847

3766848

3766849

3766850

3766851

47482_at

5175

8017599

90067_s_at

A_33_P3229402

A_33_P3405213

GE60495

GE778494

GO:0001934

GO:0002376

GO:0004888

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0005911

GO:0006909

GO:0007155

GO:0007156

GO:0007159

GO:0007165

GO:0007166

GO:0008037

GO:0016020

GO:0016192

GO:0023052

GO:0030154

GO:0030335

GO:0030667

GO:0031092

GO:0031410

GO:0032991

GO:0034330

GO:0035633

GO:0035696

GO:0036211

GO:0042803

GO:0043226

GO:0045121

GO:0048856

GO:0048870

GO:0050731

GO:0050904

GO:0060089

GO:0061028

GO:0070062

GO:0070161

GO:0070830

GO:0072011

GO:0072672

GO:0098609

GO:0098742

GO:0150107

HMNXSV003027445

HMNXSV003057981

Hs.78146.0.S2_3p_at

Hs.78146.0.S3_3p_at

Hs2.376675.1.S1_3p_at

ILMN_1689518

L34657_at

PH_hs_0004514

PH_hs_0018325

TC17001798.hg

TC17002747.hg

X96849_at

g187239_3p_a_at

Participates

as a component of

as an input of

as an output of

PECAM1 is phosphorylated (Homo sapiens)

Other forms of this molecule

PECAM1 [platelet alpha granule membrane]

PECAM1 [plasma membrane]

PECAM1 [secretory granule membrane]

p-Y713-PECAM1 [plasma membrane]

Inferred To

phospho-p-Y663,Y686-PECAM1(27-?) [plasma membrane] (Gallus gallus)

phospho-PECAM1 [plasma membrane] (Bos taurus)

phospho-PECAM1 [plasma membrane] (Canis familiaris)

phospho-PECAM1 [plasma membrane] (Sus scrofa)

phospho-Pecam1 [plasma membrane] (Mus musculus)

phospho-Pecam1 [plasma membrane] (Rattus norvegicus)

Homologues of p-Y663,Y686-PECAM1(27-?) [plasma membrane] (Sus scrofa)

Modified Residues

Name

O4'-phospho-L-tyrosine at 663

Coordinate

663

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 686

Coordinate

686

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_016880229.1, NP_000433.4, XP_016880227.1, XP_005276937.1, XP_005276939.1, XP_005276938.1, XP_011523191.1, XP_011523192.1, XP_016880228.1

OpenTargets

ENSG00000261371

HPA

ENSG00000261371-PECAM1

GeneCards

P16284

Ensembl

ENSP00000457421, ENST00000563924, ENSG00000261371

PRO

P16284

Pharos - Targets

P16284

PDB

5GNI, 5C14, 2KY5

Interactors (83)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q06124 PTPN11	4	p-Y542-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [nucleoplasm] (R-HSA-8937745) PTPN11 [cytosol] (R-HSA-162563) p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573)	0.69	7
UniProt:P09382 LGALS1	2	p-LGALS1 [endoplasmic reticulum lumen] (R-HSA-8957003) LGALS1 [endoplasmic reticulum lumen] (R-HSA-8956711)	0.675	4
UniProt:P14923 JUP	6	JUP [cytosol] (R-HSA-201598) JUP [cornified envelope] (R-HSA-8847739) JUP [specific granule lumen] (R-HSA-6799534) JUP [extracellular region] (R-HSA-6806309) JUP [ficolin-1-rich granule lumen] (R-HSA-6801028) JUP [plasma membrane] (R-HSA-437260)	0.61	7
UniProt:P12931 SRC	6	p-Y419-SRC [nucleoplasm] (R-HSA-8937690) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.59	3
UniProt:O75175 CNOT3	1	CNOT3 [cytosol] (R-HSA-429872)	0.556	3
UniProt:Q96BD6 SPSB1	1	SPSB1 [cytosol] (R-HSA-976024)	0.556	3
IntAct:EBI-25881637 CCSB			0.556	3
UniProt:Q9NX09 DDIT4	1	DDIT4 [cytosol] (R-HSA-5632374)	0.556	3
UniProt:Q8NCS7 SLC44A5	1	SLC44A5 [plasma membrane] (R-HSA-444459)	0.556	3
UniProt:Q6ZSB9 ZBT49			0.556	3
UniProt:O15273 TCAP	1	TCAP [cytosol] (R-HSA-390571)	0.556	3
UniProt:Q08AE8 SPIR1			0.556	3
IntAct:EBI-25861394 CCSB			0.556	3
UniProt:Q6ZU52 K0408			0.556	3
UniProt:Q9GZQ6 NPFFR1	1	NPFFR1 [plasma membrane] (R-HSA-389429)	0.556	3
UniProt:Q9UJD0 RIMS3			0.556	3
UniProt:Q9HB63 NTN4	1	NTN4 [plasma membrane] (R-HSA-561258)	0.556	3
UniProt:P17024 ZNF20	1	ZNF20 [nucleoplasm] (R-HSA-975024)	0.556	3
IntAct:EBI-25881483 CCSB			0.556	3
UniProt:Q9H270 VPS11	1	VPS11 [endosome membrane] (R-HSA-2197802)	0.556	3
UniProt:P46977 STT3A	1	STT3A [endoplasmic reticulum membrane] (R-HSA-265023)	0.556	3
UniProt:Q08AM6 VAC14	3	VAC14 [Golgi membrane] (R-HSA-1806235) VAC14 [early endosome membrane] (R-HSA-1806207) VAC14 [late endosome membrane] (R-HSA-1806219)	0.556	3
UniProt:Q8N302-2 Q8N3022			0.556	3
UniProt:Q96LI6 HSFY1			0.556	3
UniProt:Q9UMX3 BOK			0.556	3
UniProt:Q8TAB5 CA216			0.556	3
UniProt:P49184 DNASE1L1	2	DNASE1L1 [extracellular region] (R-HSA-6806320) DNASE1L1 [specific granule lumen] (R-HSA-6799554)	0.556	3
UniProt:Q6ZQX7-4 Q6ZQX74			0.556	3
UniProt:Q8WUY3 PRUN2			0.556	3
UniProt:Q96I25 RBM17	1	RBM17 [nucleoplasm] (R-HSA-8865891)	0.556	3
UniProt:Q9Y3D0 CIAO2B	1	FAM96B [cytosol] (R-HSA-2161124)	0.556	3
UniProt:P12757 SKIL	1	SKIL [nucleoplasm] (R-HSA-2186596)	0.556	3
UniProt:Q6NXG1 ESRP1	3	ESRP1 [nucleoplasm] (R-HSA-6803472) ESRP1(1-606)-p-RAF1(227-648) fusion [cytosol] (R-HSA-6802523) ESRP1(1-606)-RAF1(227-648) fusion [cytosol] (R-HSA-6802312)	0.556	3
UniProt:Q9P286 PAK5	2	PAK7 [plasma membrane] (R-HSA-211555) PAK5 [cytosol] (R-HSA-428459)	0.556	3
UniProt:Q9BQ29 Q9BQ29			0.556	3
UniProt:Q8IUW3 SPA2L			0.556	3
UniProt:Q6DHV7-2 Q6DHV72			0.556	3
UniProt:Q96G97-4 BSCL2			0.556	3
UniProt:Q96JJ7-2 Q96JJ72			0.556	3
UniProt:P61966-2 AP1S1			0.556	3
UniProt:P61513 RPL37A	1	RPL37A [cytosol] (R-HSA-72468)	0.556	3
UniProt:Q96GL9 F163A			0.556	3
UniProt:Q14847-2 LASP1			0.556	3
UniProt:P54819 AK2	1	AK2 [mitochondrial intermembrane space] (R-HSA-57822)	0.556	3
UniProt:O77932 DXO			0.556	3
UniProt:P19544-6 WT1			0.556	3
UniProt:O75874 IDH1	10	IDH1 R132H mutant [cytosol] (R-HSA-880015) IDH1 R132L mutant [cytosol] (R-HSA-880000) IDH1 R132S mutant [cytosol] (R-HSA-880048) IDH1 R132C mutant [cytosol] (R-HSA-880031) IDH1 [secretory granule lumen] (R-HSA-6800980) IDH1 [ficolin-1-rich granule lumen] (R-HSA-6800977) IDH1 [extracellular region] (R-HSA-6806433) IDH1 [tertiary granule lumen] (R-HSA-6800163) IDH1 [cytosol] (R-HSA-389549) IDH1 [peroxisomal matrix] (R-HSA-389546)	0.556	3
UniProt:Q96PV4 PNMA5			0.556	3
UniProt:O15287 FANCG	2	FANCG [nucleoplasm] (R-HSA-419532) FANCG [cytosol] (R-HSA-420788)	0.556	3
UniProt:Q12824 SMARCB1	1	SMARCB1 [nucleoplasm] (R-HSA-389261)	0.556	3
UniProt:Q8NC51 SERB1			0.556	3
UniProt:Q8NBT0 POC1A			0.556	3
UniProt:Q5VYS8-5 TUT7			0.556	3
UniProt:Q5T1C6 THEM4	3	THEM4 [mitochondrial matrix] (R-HSA-162408) THEM4 [cytosol] (R-HSA-6809345) THEM4 [plasma membrane] (R-HSA-199437)	0.556	3
UniProt:Q14728 MFS10			0.556	3
UniProt:O60506-4 SYNCRIP			0.556	3
UniProt:Q16549 PCSK7			0.556	3
UniProt:Q96HB5 CC120			0.556	3
UniProt:Q99619 SPSB2	1	SPSB2 [cytosol] (R-HSA-976048)	0.556	3
UniProt:Q9H7C4 SYNCI			0.556	3
UniProt:Q6XD76 ASCL4			0.556	3
UniProt:Q9NS73-5 MBIP			0.556	3
UniProt:Q4G1C9-2 Q4G1C92			0.556	3
UniProt:Q99504 EYA3	2	p-EYA3 [nucleoplasm] (R-HSA-5683979) EYA3 [nucleoplasm] (R-HSA-5683622)	0.556	3
UniProt:Q99944 EGFL8			0.556	3
UniProt:Q7Z403 TMC6	3	TMC6 [tertiary granule membrane] (R-HSA-6800920) TMC6 [plasma membrane] (R-HSA-6800446) TMC6 [specific granule membrane] (R-HSA-6799712)	0.556	3
UniProt:Q5JSH3 WDR44			0.556	3
UniProt:P15923-3 TCF3			0.556	3
UniProt:I6L9F6 I6L9F6			0.556	3
UniProt:Q7Z614-3 SNX20			0.556	3
UniProt:Q9UQM7 CAMK2A	6	p-T286-CAMK2A [plasma membrane] (R-HSA-432796) p-T286-CAMK2A [nucleoplasm] (R-HSA-444797) p-T286-CAMK2A [endocytic vesicle membrane] (R-HSA-416999) p-T286,T305,T306-CAMK2A [cytosol] (R-HSA-4332334) CAMK2A [cytosol] (R-HSA-4332329) p-T286-CAMK2A [cytosol] (R-HSA-445368)	0.556	3
UniProt:Q13428-5 TCOF1			0.556	3
UniProt:Q8TBJ4 PLPPR1	1	LPPR1 [plasma membrane] (R-HSA-6797625)	0.556	3
IntAct:EBI-25833683 CCSB			0.556	3
UniProt:Q0VD86 INCA1			0.556	3
UniProt:Q13405 MRPL49	1	MRPL49 [mitochondrial inner membrane] (R-HSA-5368260)	0.556	3
UniProt:P26651 ZFP36	2	p-S60,S186-ZFP36 [cytosol] (R-HSA-450496) ZFP36 [cytosol] (R-HSA-450562)	0.556	3
UniProt:Q96E93 KLRG1	1	KLRG1 [plasma membrane] (R-HSA-198006)	0.556	3
UniProt:Q6IAA8 LAMTOR1	5	LAMTOR1 [specific granule membrane] (R-HSA-6799631) LAMTOR1 [lysosomal membrane] (R-HSA-5653582) LAMTOR1 [azurophil granule membrane] (R-HSA-6799633) LAMTOR1 [plasma membrane] (R-HSA-6806270) LAMTOR1 [ficolin-1-rich granule membrane] (R-HSA-6801003)	0.556	3
UniProt:Q12888 TP53BP1	3	monoSUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418) TP53BP1 [nucleoplasm] (R-HSA-61175)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.483	3
UniProt:P29350 PTPN6	5	PTPN6 [specific granule lumen] (R-HSA-6799641) PTPN6 [extracellular region] (R-HSA-6806315) PTPN6 [tertiary granule lumen] (R-HSA-6800952) PTPN6 [nucleoplasm] (R-HSA-9008911) PTPN6 [cytosol] (R-HSA-197938)	0.462	4

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