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Interaction of PECAM-1 and SHP-1
Stable Identifier
R-HSA-210277
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
PECAM1 interactions (Homo sapiens)
Interaction of PECAM-1 and SHP-1 (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Platelet sensitization by LDL (Homo sapiens)
Interaction of PECAM-1 and SHP-1 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The phosphorylation of two tandem tyrosine residues (Y663 and Y686) within the cytoplasmic domain of PECAM-1 is required for the downstream signalling events observed following PECAM-1 ligation. Both SH2 domains of SHP-1 are required in tandem to bind PECAM-1.
Literature References
PubMed ID
Title
Journal
Year
9774457
Recruitment and activation of SHP-1 protein-tyrosine phosphatase by human platelet endothelial cell adhesion molecule-1 (PECAM-1). Identification of immunoreceptor tyrosine-based inhibitory motif-like binding motifs and substrates.
Gamble, JR
,
Hua, CT
,
Vadas, MA
,
Jackson, DE
J Biol Chem
1998
Participants
Input
p-Y663,Y686-PECAM1(27-?) [plasma membrane]
(Homo sapiens)
PTPN6 [cytosol]
(Homo sapiens)
Output
PECAM-1:SHP-1 complex [plasma membrane]
(Homo sapiens)
Participates
as an event of
Platelet sensitization by LDL (Homo sapiens)
PECAM1 interactions (Homo sapiens)
Orthologous Events
Interaction of PECAM-1 and SHP-1 (Bos taurus)
Interaction of PECAM-1 and SHP-1 (Canis familiaris)
Interaction of PECAM-1 and SHP-1 (Gallus gallus)
Interaction of PECAM-1 and SHP-1 (Mus musculus)
Interaction of PECAM-1 and SHP-1 (Rattus norvegicus)
Interaction of PECAM-1 and SHP-1 (Sus scrofa)
Authored
Garapati, P V (2008-02-26)
de Bono, B (2008-02-26)
Reviewed
Trowsdale, J (2008-02-26)
Created
Garapati, P V (2008-01-10)
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