Reactome | Interaction of integrin alphaVbeta3 with PECAM1

Interaction of integrin alphaVbeta3 with PECAM1

Stable Identifier

R-HSA-210304

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Interaction of integrin alphaVbeta3 with PECAM1

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Alpha v beta 3 integrin is one of the potential heterophilic ligands of PECAM-1 that is involved in down-regulation of T-cell responses. The heterophilic interaction of alpha v beta 3 integrin on endothelial cells with PEACAM-1 on leukocytes increases the adhesive function of beta integrins on T cells, monocytes, neutrophils and NK cells suggesting that leukocyte PEACAM-1 act as a signaling molecule.

Literature References

PubMed ID	Title	Journal	Year
7542249	CD31/PECAM-1 is a ligand for alpha v beta 3 integrin involved in adhesion of leukocytes to endothelium Piali, L, Hammel, P, Uherek, C, Bachmann, F, Gisler, RH, Dunon, D, Imhof, BA	J Cell Biol	1995
8838667	Identification of alpha v beta 3 as a heterotypic ligand for CD31/PECAM-1 Buckley, CD, Doyonnas, R, Newton, JP, Blystone, SD, Brown, EJ, Watt, SM, Simmons, DL	J Cell Sci	1996