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SLC1A1 [plasma membrane]
Stable Identifier
R-HSA-210414
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
EAAC1, EAAT3
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter release cycle (Homo sapiens)
Glutamate Neurotransmitter Release Cycle (Homo sapiens)
SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ (Homo sapiens)
SLC1A1-3,6,7 [plasma membrane] (Homo sapiens)
SLC1A1 [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of inorganic cations/anions and amino acids/oligopeptides (Homo sapiens)
SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol (Homo sapiens)
SLC1A1-3,6,7 [plasma membrane] (Homo sapiens)
SLC1A1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P43005 SLC1A1
Gene Names
SLC1A1, EAAC1, EAAT3, HEAAC1
Chain
chain:1-524
Reference Genes
BioGPS Gene:6505 SLC1A1
COSMIC (genes):SLC1A1 SLC1A1
CTD Gene:6505 SLC1A1
dbSNP Gene:6505 SLC1A1
ENSEMBL:ENSG00000106688 SLC1A1
ENSEMBL_homo_sapiens_GENE:ENSG00000106688.12 SLC1A1
HGNC:10939 SLC1A1
KEGG Gene (Homo sapiens):6505 SLC1A1
Monarch:6505 SLC1A1
NCBI Gene:6505 SLC1A1
OMIM:133550 SLC1A1
UCSC:P43005 SLC1A1
Reference Transcript
RefSeq:NM_004170.5 SLC1A1
Other Identifiers
11721351_at
11721352_at
17083261
206396_PM_at
206396_at
213664_PM_at
213664_at
3160659
3160660
3160674
3160684
3160685
3160687
3160688
3160689
3160690
3160691
3160692
3160697
3160699
3160700
3160701
3160705
38267_at
38268_at
6505
8154135
A_14_P105964
A_23_P216468
A_24_P232252
GE58898
GO:0001662
GO:0001932
GO:0001975
GO:0002027
GO:0003013
GO:0005215
GO:0005253
GO:0005313
GO:0005314
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005768
GO:0005783
GO:0005886
GO:0006575
GO:0006749
GO:0006750
GO:0006790
GO:0006801
GO:0006811
GO:0006836
GO:0006865
GO:0006882
GO:0006886
GO:0007212
GO:0007215
GO:0007268
GO:0007420
GO:0007611
GO:0007613
GO:0007625
GO:0007626
GO:0009410
GO:0009986
GO:0010460
GO:0010467
GO:0010842
GO:0012501
GO:0015108
GO:0015179
GO:0015183
GO:0015293
GO:0015501
GO:0015813
GO:0016020
GO:0016192
GO:0016324
GO:0016595
GO:0019221
GO:0022008
GO:0023052
GO:0030154
GO:0030424
GO:0030425
GO:0030534
GO:0031410
GO:0031901
GO:0031902
GO:0031982
GO:0032279
GO:0033229
GO:0034330
GO:0034599
GO:0035633
GO:0036211
GO:0036293
GO:0042417
GO:0042802
GO:0042883
GO:0043005
GO:0043025
GO:0043083
GO:0043197
GO:0043198
GO:0043204
GO:0043226
GO:0043278
GO:0043524
GO:0043679
GO:0045121
GO:0045184
GO:0045202
GO:0046872
GO:0048514
GO:0048678
GO:0048856
GO:0050808
GO:0050877
GO:0051402
GO:0051938
GO:0055037
GO:0055038
GO:0055065
GO:0055085
GO:0060013
GO:0060041
GO:0060047
GO:0060291
GO:0061744
GO:0070062
GO:0070633
GO:0070777
GO:0070778
GO:0070779
GO:0071242
GO:0071288
GO:0071314
GO:0071407
GO:0071577
GO:0071944
GO:0072347
GO:0090313
GO:0090461
GO:0097049
GO:0097386
GO:0097440
GO:0098685
GO:0098712
GO:0098793
GO:0098877
GO:0099170
GO:0099544
GO:0140009
GO:0140010
GO:0150002
GO:0150104
GO:1902476
GO:1903712
GO:1903926
GO:1990635
GO:1990708
HMNXSV003000939
Hs.91139.1.A1_3p_at
ILMN_1658917
PH_hs_0005070
TC09000029.hg
U08989_at
g4759121_3p_at
Participates
as a member of
SLC1A1-3,6,7 [plasma membrane] (Homo sapiens)
Other forms of this molecule
SLC1A1 I395del [plasma membrane]
SLC1A1 84kb_del [plasma membrane]
SLC1A1 R445W [plasma membrane]
Inferred To
slc1a1 [plasma membrane]
(Danio rerio)
slc1a1 [plasma membrane]
(Xenopus tropicalis)
Eaat1 [plasma membrane]
(Drosophila melanogaster)
glt-1 [plasma membrane]
(Caenorhabditis elegans)
SLC1A1 [plasma membrane]
(Bos taurus)
SLC1A1 [plasma membrane]
(Canis familiaris)
SLC1A1 [plasma membrane]
(Gallus gallus)
SLC1A1 [plasma membrane]
(Mus musculus)
SLC1A1 [plasma membrane]
(Rattus norvegicus)
SLC1A1 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_004161.4
ZINC - World Drugs
EAA3_HUMAN
Guide to Pharmacology - Targets
870
OpenTargets
ENSG00000106688
ZINC - FDA approved
EAA3_HUMAN
ZINC - Substances
EAA3_HUMAN
ZINC target
P43005
ZINC - Biogenic
EAA3_HUMAN
PRO
P43005
PDB
8CUJ
,
8CUD
,
8CTD
,
8CV3
,
8CTC
,
6S3Q
,
6X3F
,
7NSG
,
6X2Z
,
8CUA
,
8CV2
,
8CUI
,
6X3E
,
6X2L
ZINC - Metabolites
EAA3_HUMAN
HPA
ENSG00000106688-SLC1A1
GeneCards
P43005
Ensembl
ENST00000262352
,
ENSG00000106688
,
ENSP00000262352
Pharos - Targets
P43005
Orphanet
22150
ZINC - Predictions - Purchasable
EAA3_HUMAN
HMDB Protein
HMDBP03094
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P78382 SLC35A1
2
SLC35A1 [Golgi membrane]
(R-HSA-727812)
SLC35A1 V93Cfs*17 [Golgi membrane]
(R-HSA-5651957)
0.556
3
UniProt:O60493 SNX3
3
SNX3 [cytosol]
(R-HSA-3247743)
PolyUb-SNX3 [endosome membrane]
(R-HSA-6782993)
SNX3 [endosome membrane]
(R-HSA-6782991)
0.527
2
UniProt:O15357 INPPL1
1
INPPL1 [cytosol]
(R-HSA-913354)
0.527
3
UniProt:Q6UXV4 APOOL
3
APOOL (MIC27) [mitochondrial inner membrane]
(R-HSA-8949612)
APOOL [extracellular region]
(R-HSA-8862979)
APOOL [platelet alpha granule lumen]
(R-HSA-8863003)
0.527
2
UniProt:Q9NPF0 CD320
2
CD320 [plasma membrane]
(R-HSA-2980909)
CD320 E88del [plasma membrane]
(R-HSA-3325560)
0.527
2
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