Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
Requirement by 'Ca2+ [cytosol]'
Stable Identifier
R-HSA-210503
Type
Requirement
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Drosophila melanogaster
Mus musculus
Rattus norvegicus
Sus scrofa
Expand all
Neuronal System (Bos taurus)
Transmission across Chemical Synapses (Bos taurus)
Neurotransmitter release cycle (Bos taurus)
Glutamate Neurotransmitter Release Cycle (Bos taurus)
Release of L-Glutamate at the synapse (Bos taurus)
Ca2+ [cytosol]
Cellular responses to stimuli (Caenorhabditis elegans)
Cellular responses to mechanical stimuli (Caenorhabditis elegans)
Response of endothelial cells to shear stress (Caenorhabditis elegans)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Caenorhabditis elegans)
Phosphorylation of PDPK1 on serine-241 (Caenorhabditis elegans)
Ca2+ [cytosol]
Metabolism (Caenorhabditis elegans)
Metabolism of carbohydrates and carbohydrate derivatives (Caenorhabditis elegans)
Glycogen metabolism (Caenorhabditis elegans)
Glycogen breakdown (glycogenolysis) (Caenorhabditis elegans)
glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Caenorhabditis elegans)
Ca2+ [cytosol]
Neuronal System (Caenorhabditis elegans)
Transmission across Chemical Synapses (Caenorhabditis elegans)
Neurotransmitter release cycle (Caenorhabditis elegans)
Glutamate Neurotransmitter Release Cycle (Caenorhabditis elegans)
Release of L-Glutamate at the synapse (Caenorhabditis elegans)
Ca2+ [cytosol]
Sensory Perception (Caenorhabditis elegans)
Visual phototransduction (Caenorhabditis elegans)
The phototransduction cascade (Caenorhabditis elegans)
Inactivation, recovery and regulation of the phototransduction cascade (Caenorhabditis elegans)
CALM1:Ca2+ binds CNG channel (Caenorhabditis elegans)
Ca2+ [cytosol]
PP2A dephosphorylates p-RHO to RHO (Caenorhabditis elegans)
Ca2+ [cytosol]
Transport of small molecules (Caenorhabditis elegans)
Glycosphingolipid transport (Caenorhabditis elegans)
ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Caenorhabditis elegans)
Ca2+ [cytosol]
Ion channel transport (Caenorhabditis elegans)
Stimuli-sensing channels (Caenorhabditis elegans)
ANOs transport cytosolic Cl- to extracellular region (Caenorhabditis elegans)
Ca2+ [cytosol]
TTYH2/3 transport cytosolic Cl- to extracellular region (Caenorhabditis elegans)
Ca2+ [cytosol]
Neuronal System (Canis familiaris)
Transmission across Chemical Synapses (Canis familiaris)
Neurotransmitter release cycle (Canis familiaris)
Glutamate Neurotransmitter Release Cycle (Canis familiaris)
Release of L-Glutamate at the synapse (Canis familiaris)
Ca2+ [cytosol]
Neuronal System (Drosophila melanogaster)
Transmission across Chemical Synapses (Drosophila melanogaster)
Neurotransmitter release cycle (Drosophila melanogaster)
Glutamate Neurotransmitter Release Cycle (Drosophila melanogaster)
Release of L-Glutamate at the synapse (Drosophila melanogaster)
Ca2+ [cytosol]
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter release cycle (Homo sapiens)
Glutamate Neurotransmitter Release Cycle (Homo sapiens)
Release of L-Glutamate at the synapse (Homo sapiens)
Ca2+ [cytosol]
Cellular responses to stimuli (Mus musculus)
Cellular responses to mechanical stimuli (Mus musculus)
Response of endothelial cells to shear stress (Mus musculus)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Mus musculus)
Phosphorylation of PDPK1 on serine-241 (Mus musculus)
Ca2+ [cytosol]
Secretion of ADM (Adrenomedullin) (Mus musculus)
Ca2+ [cytosol]
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Mus musculus)
PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2) (Mus musculus)
Ca2+ [cytosol]
Extracellular matrix organization (Mus musculus)
Degradation of the extracellular matrix (Mus musculus)
CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Mus musculus)
Ca2+ [cytosol]
Metabolism (Mus musculus)
Metabolism of carbohydrates and carbohydrate derivatives (Mus musculus)
Glycogen metabolism (Mus musculus)
Glycogen breakdown (glycogenolysis) (Mus musculus)
glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP (Mus musculus)
Ca2+ [cytosol]
glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP (Mus musculus)
Ca2+ [cytosol]
Metabolism of lipids (Mus musculus)
Phospholipid metabolism (Mus musculus)
Glycerophospholipid biosynthesis (Mus musculus)
CPNEs bind PL (Mus musculus)
Ca2+ [cytosol]
Muscle contraction (Mus musculus)
Cardiac conduction (Mus musculus)
Ion homeostasis (Mus musculus)
RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Mus musculus)
Ca2+ [cytosol]
Neuronal System (Mus musculus)
Transmission across Chemical Synapses (Mus musculus)
Neurotransmitter release cycle (Mus musculus)
Glutamate Neurotransmitter Release Cycle (Mus musculus)
Release of L-Glutamate at the synapse (Mus musculus)
Ca2+ [cytosol]
Sensory Perception (Mus musculus)
Visual phototransduction (Mus musculus)
The phototransduction cascade (Mus musculus)
Inactivation, recovery and regulation of the phototransduction cascade (Mus musculus)
CALM1:Ca2+ binds CNG channel (Mus musculus)
Ca2+ [cytosol]
PP2A dephosphorylates p-RHO to RHO (Mus musculus)
Ca2+ [cytosol]
Transport of small molecules (Mus musculus)
Glycosphingolipid transport (Mus musculus)
ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane (Mus musculus)
Ca2+ [cytosol]
Ion channel transport (Mus musculus)
Stimuli-sensing channels (Mus musculus)
ANO1 transports cytosolic Cl- to extracellular region (Mus musculus)
Ca2+ [cytosol]
ANOs transport cytosolic Cl- to extracellular region (Mus musculus)
Ca2+ [cytosol]
BESTs transport cytosolic Cl- to extracellular region (Mus musculus)
Ca2+ [cytosol]
CLCAs self cleave (Mus musculus)
Ca2+ [cytosol]
RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol (Mus musculus)
Ca2+ [cytosol]
TTYH2/3 transport cytosolic Cl- to extracellular region (Mus musculus)
Ca2+ [cytosol]
Neuronal System (Rattus norvegicus)
Transmission across Chemical Synapses (Rattus norvegicus)
Neurotransmitter release cycle (Rattus norvegicus)
Glutamate Neurotransmitter Release Cycle (Rattus norvegicus)
Release of L-Glutamate at the synapse (Rattus norvegicus)
Ca2+ [cytosol]
Neuronal System (Sus scrofa)
Transmission across Chemical Synapses (Sus scrofa)
Neurotransmitter release cycle (Sus scrofa)
Glutamate Neurotransmitter Release Cycle (Sus scrofa)
Release of L-Glutamate at the synapse (Sus scrofa)
Ca2+ [cytosol]
Regulation participants
Regulation type
Requirement
Regulated entity
CPNEs bind PL
Regulated entity
CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins
Regulated entity
CALM1:Ca2+ binds CNG channel
Regulated entity
CALM1:Ca2+ binds CNG channel
Regulated entity
CLCAs self cleave
Regulated entity
ANO1 transports cytosolic Cl- to extracellular region
Regulated entity
TTYH2/3 transport cytosolic Cl- to extracellular region
Regulated entity
TTYH2/3 transport cytosolic Cl- to extracellular region
Regulated entity
ANOs transport cytosolic Cl- to extracellular region
Regulated entity
ANOs transport cytosolic Cl- to extracellular region
Regulated entity
RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol
Regulated entity
BESTs transport cytosolic Cl- to extracellular region
Regulated entity
PP2A dephosphorylates p-RHO to RHO
Regulated entity
PP2A dephosphorylates p-RHO to RHO
Regulated entity
PTPN1 (PTP1B) dephosphorylates tyrosine-24 of ANXA2 (Annexin-2)
Regulated entity
Phosphorylation of PDPK1 on serine-241
Regulated entity
Phosphorylation of PDPK1 on serine-241
Regulated entity
ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane
Regulated entity
ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane
Regulated entity
glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP
Regulated entity
glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP
Regulated entity
glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP
Regulated entity
Release of L-Glutamate at the synapse
Regulated entity
Release of L-Glutamate at the synapse
Regulated entity
Release of L-Glutamate at the synapse
Regulated entity
Release of L-Glutamate at the synapse
Regulated entity
Release of L-Glutamate at the synapse
Regulated entity
Release of L-Glutamate at the synapse
Regulated entity
Release of L-Glutamate at the synapse
Regulated entity
Release of L-Glutamate at the synapse
Regulated entity
Secretion of ADM (Adrenomedullin)
Regulator
Ca2+ [cytosol]
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text