STXBP1-1 [cytosol]

Stable Identifier
R-HSA-210514
Type
Genes and Transcripts [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
MUNC18, STXBP1 isoform 1
STXBP1-1 [cytosol] icon
Locations in the PathwayBrowser
General

Munc 18 interacts with syntaxin in the plasma membrane, with Mint (Munc 18 interacting) which in turn interacts with CASK and neurexins. Munc18 also interacts with granulophilin. Granulophilin is interacts simultaneously with syntaxin and Munc18. These interactions are believed to be involved in the docking of the synaptic vesicle to the plasma membrane. However, the sequence of events is unclear.

Literature References
PubMed ID Title Journal Year
11010978 Modulation of amyloid precursor protein metabolism by X11alpha /Mint-1. A deletion analysis of protein-protein interaction domains.

Turner, RS, Borg, JP, Margolis, B, Mueller, HT

J Biol Chem 2000
External Reference Information
External Reference
Gene Names
STXBP1, UNC18A
Other Identifiers
0006450341
11729699_a_at
11729700_a_at
11729701_x_at
11746786_a_at
17089371
202260_s_at
3189933
3189934
3189942
3189943
3189946
3189947
3189948
3189951
3189953
3189954
3189955
3189957
3189958
3189959
3189960
3189961
3189962
3189963
3189964
3189965
3189967
3189968
3189969
3189970
3189971
3189972
33942_s_at
6812
8158059
A_24_P201171
D63851_at
GE79675
GO:0000003
GO:0000149
GO:0000902
GO:0002376
GO:0002576
GO:0003006
GO:0003674
GO:0003723
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0005856
GO:0005886
GO:0006810
GO:0006836
GO:0006886
GO:0006887
GO:0006904
GO:0006950
GO:0007155
GO:0007267
GO:0007269
GO:0007274
GO:0007412
GO:0008150
GO:0008219
GO:0010807
GO:0015031
GO:0016020
GO:0016082
GO:0016188
GO:0016192
GO:0017075
GO:0019899
GO:0019901
GO:0019904
GO:0019905
GO:0021700
GO:0022607
GO:0030141
GO:0030154
GO:0030424
GO:0031091
GO:0031333
GO:0031338
GO:0031410
GO:0031630
GO:0032229
GO:0032355
GO:0032991
GO:0035493
GO:0035542
GO:0042802
GO:0043226
GO:0043274
GO:0043306
GO:0043524
GO:0045335
GO:0045921
GO:0045956
GO:0047485
GO:0048471
GO:0048787
GO:0048856
GO:0050821
GO:0060292
GO:0061024
GO:0065003
GO:0070062
GO:0070527
GO:0071346
GO:0072659
GO:0098793
GO:0098794
GO:0098978
GO:0099525
GO:0106022
GO:1903296
GO:2000367
HMNXSV003011439
ILMN_1728747
ILMN_1810657
ILMN_2414878
PH_hs_0023811
TC09000668.hg
g4507296_3p_a_at
Participates
Inferred To
Cross References
OpenTargets
GeneCards
PRO
Pharos - Targets
Orphanet
PDB
HMDB Protein
Interactors (18)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q8N4C7 STX19      0.805 9
 UniProt:O00635 TRIM38  1 0.805 9
 UniProt:Q13190 STX5  5 0.718 6
 UniProt:O75558 STX11      0.718 6
 UniProt:P42858 HTT  1 0.666 7
 UniProt:P05067 APP  20 0.666 7
 UniProt:P21917 DRD4  1 0.556 3
 UniProt:O75376 NCOR1  2 0.556 3
 UniProt:Q0VDD7 BRME1      0.556 3
 UniProt:O14901 KLF11      0.556 3
 UniProt:Q96C24 SYTL4  2 0.556 3
 UniProt:P50222 MEOX2      0.556 3
 UniProt:P28482 MAPK1  18 0.556 3
 UniProt:Q8N0Z3 SPICE      0.556 3
 IntAct:EBI-25911596 CCSB      0.556 3
 UniProt:Q6IPU0 CENPP  2 0.556 3
 UniProt:P60880 SNAP25  7 0.527 2
 UniProt:P11142 HSPA8  10 0.499 2
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