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HNF1B- and FGF10-dependent synthesis of PTF1A protein
Stable Identifier
R-HSA-210788
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Developmental Biology (Homo sapiens)
Regulation of beta-cell development (Homo sapiens)
Regulation of gene expression in early pancreatic precursor cells (Homo sapiens)
HNF1B- and FGF10-dependent synthesis of PTF1A protein (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The PTF1A gene is transcribed, its mRNA is translated, and the protein product is transported to the nucleus. PTF1A transcription requires the activity of the HNF1B transcription factor and FGF10. These events and interactions have not been studied directly in humans, but are inferred from corresponding ones worked out in the mouse.
Participants
Input
PTF1A gene [nucleoplasm]
(Homo sapiens)
Output
PTF1A [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Regulation of gene expression in early pancreatic precursor cells (Homo sapiens)
This event is regulated
Positively by
Regulator
HNF1B [nucleoplasm]
(Homo sapiens)
Regulator
FGF10 [extracellular region]
(Homo sapiens)
Inferred From
FGF10 activates Ptf1 expression in early pancreatic buds (Mus musculus)
HNF1b transactivates Ptf1a (Mus musculus)
Authored
Tello-Ruiz, MK (2008-05-24)
Ferrer, J (2008-05-24)
Reviewed
Jensen, J (2008-05-13)
Created
D'Eustachio, P (2008-01-16)
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