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HNF6-dependent synthesis of NEUROG3 protein during morphogenesis
Stable Identifier
R-HSA-210836
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Regulation of beta-cell development (Homo sapiens)
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells (Homo sapiens)
HNF6-dependent synthesis of NEUROG3 protein during morphogenesis (Homo sapiens)
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The NEUROG3 gene is transcribed, its mRNA is translated, and the protein product is transported to the nucleus during morphogenesis of the pancreas. NEUROG3 transcription requires the activity of the HNF6 transcription factor. HES1 represses NEUROG3 transcription. In vivo, the interplay between HNF6 and HES6 deteremines the timing and level of NEUROG3 expression, which is critical for normal development of the pancreas. These events and interactions have not been studied directly in humans, but are inferred from corresponding ones worked out in the mouse.
Participants
Input
NEUROG3 gene [nucleoplasm]
(Homo sapiens)
Output
NEUROG3 [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells (Homo sapiens)
This event is regulated
Negatively by
Regulator
HES1 [nucleoplasm]
(Homo sapiens)
Positively by
Regulator
ONECUT1 [nucleoplasm]
(Homo sapiens)
Inferred From
Hnf6-dependent synthesis of Ngn3 protein during morphogenesis (Mus musculus)
Authored
Tello-Ruiz, MK (2008-05-24)
Ferrer, J (2008-05-24)
Reviewed
Jensen, J (2008-05-13)
Created
D'Eustachio, P (2008-01-17)
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