Reactome | Tie2 Signaling

Tie2 Signaling

Stable Identifier

R-HSA-210993

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this pathway in the Pathway Browser

The Tie2/Tek receptor tyrosine kinase plays a pivotal role in vascular and hematopoietic development and is expressed exclusively on endothelial lineage. Tie2 interacts with a group of ligands belonging to angiopoietin family and undergoes activation.
These ligands show opposing actions, angiopoietin 1 and angiopoietin 4 stimulate the Tie2 phosphorylation and angiopoietin 2 inhibits it. Upon tyrosine phosphorylation Tie2 acts as a scaffold for various signaling proteins involved in different signal transduction cascades that can effect survival of endothelium and angiogenic sprout formation.

Literature References

PubMed ID	Title	Journal	Year
11191051	Tek/Tie2 signaling: new and old partners Dumont, DJ, Jones, N	Cancer Metastasis Rev	2000
9764820	The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R Dumont, DJ, Jones, N	Oncogene	1998
11969368	The angiopoietins and Tie2/Tek: adding to the complexity of cardiovascular development Ward, NL, Dumont, DJ	Semin Cell Dev Biol	2002
11566266	Angiopoietin and Tie signaling pathways in vascular development Sato, TN, Loughna, S	Matrix Biol	2001