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p-T24,S256,S319-FOXO1 [cytosol]
Stable Identifier
R-HSA-211158
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phospho-Forkhead box protein O1A (T24, S256, S319), FOXO1_HUMAN, FOXO1A
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Regulation of beta-cell development (Homo sapiens)
Regulation of gene expression in beta cells (Homo sapiens)
AKT-mediated inactivation of FOXO1A (Homo sapiens)
Phosphorylated FOXO1A is excluded from the nucleus (Homo sapiens)
p-T24,S256,S319-FOXO1 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
Regulation of localization of FOXO transcription factors (Homo sapiens)
14-3-3 proteins bind AKT-phosphorylated FOXO1 (Homo sapiens)
p-T24,S256,S319-FOXO1 [cytosol] (Homo sapiens)
p-T24,S256,S319-FOXO1:YWHAZ,YWHAQ,YWHAG,YWHAB [cytosol] (Homo sapiens)
p-T24,S256,S319-FOXO1 [cytosol] (Homo sapiens)
AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol (Homo sapiens)
p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4 [cytosol] (Homo sapiens)
p-T24,S256,S319-FOXO1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q12778 FOXO1
Gene Names
FOXO1, FKHR, FOXO1A
Chain
chain:1-655
Reference Genes
BioGPS Gene:2308 FOXO1
COSMIC (genes):FOXO1 FOXO1
CTD Gene:2308 FOXO1
dbSNP Gene:2308 FOXO1
ENSEMBL:ENSG00000150907 FOXO1
ENSEMBL_homo_sapiens_GENE:ENSG00000150907.10 FOXO1
HGNC:3819 FOXO1
KEGG Gene (Homo sapiens):2308 FOXO1
Monarch:2308 FOXO1
NCBI Gene:2308 FOXO1
OMIM:136533 FOXO1
UCSC:Q12778 FOXO1
Reference Transcript
RefSeq:NM_002015.3 FOXO1
Other Identifiers
11727927_a_at
11727928_at
11727929_a_at
11755772_a_at
16778392
202723_PM_s_at
202723_s_at
202724_PM_s_at
202724_s_at
2308
3510859
3510861
3510904
3510905
3510906
3510907
3510908
3510909
40570_at
7971177
A_23_P151426
A_24_P22079
GE54250
GO:0000122
GO:0000785
GO:0000978
GO:0000981
GO:0001227
GO:0001228
GO:0001568
GO:0001659
GO:0001678
GO:0003012
GO:0003676
GO:0003677
GO:0003682
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005739
GO:0005829
GO:0005975
GO:0006111
GO:0006351
GO:0006355
GO:0006357
GO:0006473
GO:0006914
GO:0006915
GO:0006974
GO:0008013
GO:0008286
GO:0009267
GO:0010467
GO:0010508
GO:0012501
GO:0023052
GO:0030154
GO:0030163
GO:0031490
GO:0031625
GO:0032868
GO:0032869
GO:0032873
GO:0034393
GO:0034599
GO:0036211
GO:0042127
GO:0042593
GO:0043065
GO:0043066
GO:0043226
GO:0043565
GO:0045444
GO:0045599
GO:0045722
GO:0045732
GO:0045892
GO:0045893
GO:0045944
GO:0046676
GO:0048856
GO:0051721
GO:0060070
GO:0060260
GO:0070417
GO:0070542
GO:0071455
GO:0071732
GO:0090090
GO:0097009
GO:0097150
GO:0140110
GO:1903243
GO:1990841
GO:2000177
GO:2000377
HMNXSV003026619
Hs.170133.0.A1_3p_s_at
ILMN_1738816
PH_hs_0010156
TC13001719.hg
U02310_at
U36922_at
g9257221_3p_a_at
Participates
as an output of
Phosphorylated FOXO1A is excluded from the nucleus (Homo sapiens)
as a component of
p-T24,S256,S319-FOXO1:YWHAZ,YWHAQ,YWHAG,YWHAB [cytosol] (Homo sapiens)
as an input of
14-3-3 proteins bind AKT-phosphorylated FOXO1 (Homo sapiens)
as a member of
p-T24,S256,S319-FOXO1,p-T32,S253,S315-FOXO3,p-T32,S197,S262-FOXO4 [cytosol] (Homo sapiens)
Other forms of this molecule
p-S218-FOXO1 [nucleoplasm]
Ac-K245,K248,K265-FOXO1 [nucleoplasm]
FOXO1 [nucleoplasm]
p-T24,S256,S319-FOXO1 [nucleoplasm]
Inferred To
phospho-p-T24,S256,S319-FOXO1 [cytosol]
(Gallus gallus)
phospho-foxo [cytosol]
(Drosophila melanogaster)
phospho-foxo1 [cytosol]
(Xenopus tropicalis)
phospho-Foxo1 [cytosol]
(Mus musculus)
phospho-Foxo1 [cytosol]
(Rattus norvegicus)
phospho-daf-16 [cytosol]
(Caenorhabditis elegans)
phospho-FOXO1 [cytosol]
(Bos taurus)
phospho-FOXO1 [cytosol]
(Canis familiaris)
phospho-FOXO1 [cytosol]
(Sus scrofa)
phospho-foxo1a [cytosol]
(Danio rerio)
Modified Residues
Name
O-phospho-L-threonine at 24
Coordinate
24
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 256
Coordinate
256
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 319
Coordinate
319
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_002006.2
OpenTargets
ENSG00000150907
ZINC - Substances
FOXO1_HUMAN
GeneCards
Q12778
HPA
ENSG00000150907-FOXO1
ZINC target
Q12778
Ensembl
ENST00000379561
,
ENSG00000150907
,
ENSP00000368880
PRO
Q12778
Pharos - Targets
Q12778
ZINC - Predictions - Purchasable
FOXO1_HUMAN
Orphanet
16069
PDB
3CO7
,
6QVW
,
5DUI
,
6QZR
,
3COA
,
6QZS
,
8A65
,
8A62
,
4LG0
,
3CO6
,
6LBI
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.788
6
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.745
6
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.745
6
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.702
4
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.671
5
UniProt:P06493 CDK1
11
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
p-Y4-CDK1 [cytosol]
(R-HSA-9836187)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
CDK1 [nucleoplasm]
(R-HSA-68889)
CDK1 [cytosol]
(R-HSA-170075)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
0.645
5
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.643
3
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.639
8
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.623
5
UniProt:Q01105 SET
1
SET [nucleoplasm]
(R-HSA-451201)
0.591
5
UniProt:P14635 CCNB1
4
CCNB1 [nucleoplasm]
(R-HSA-68901)
p-4S-CCNB1 [cytosol]
(R-HSA-170058)
p-4S-CCNB1 [nucleoplasm]
(R-HSA-170049)
CCNB1 [cytosol]
(R-HSA-157451)
0.571
2
UniProt:P31749 AKT1
14
p-T308,S473-AKT1 E17K [nucleoplasm]
(R-HSA-2399994)
p-T308,S473-AKT1 E17K [cytosol]
(R-HSA-2243935)
AKT1 E17K [cytosol]
(R-HSA-2219526)
p-S473-AKT1 E17K [plasma membrane]
(R-HSA-2243944)
AKT1 E17K [plasma membrane]
(R-HSA-1500573)
p-S473-AKT1 [cytosol]
(R-HSA-9841264)
p-T308,S473-AKT1 [plasma membrane]
(R-HSA-199430)
p-Y315,Y326-AKT1 [cytosol]
(R-HSA-8848757)
p-T308-AKT1 [cytosol]
(R-HSA-198634)
AKT1 [cytosol]
(R-HSA-58252)
AKT1 [plasma membrane]
(R-HSA-199416)
p-S473-AKT1 [plasma membrane]
(R-HSA-377265)
p-T308,S473-AKT1 [cytosol]
(R-HSA-198356)
p-T308,S473-AKT1 [nucleoplasm]
(R-HSA-198357)
0.571
2
UniProt:Q92793 CREBBP
4
monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]
(R-HSA-3927877)
FOXO4-S-S-CREBBP [nucleoplasm]
(R-HSA-9617684)
CREBBP [cytosol]
(R-HSA-9756493)
CREBBP [nucleoplasm]
(R-HSA-193545)
0.564
3
UniProt:Q923E4 Sirt1
2
Sirt1 [nucleoplasm]
(R-MMU-5211238)
SIRT1 [nucleoplasm]
(R-MMU-427531)
0.544
2
UniProt:P14921-3 ETS1
0.544
2
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.508
2
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