Reactome | AKT phosphorylates FOXO1A

AKT phosphorylates FOXO1A

Stable Identifier

R-HSA-211164

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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One or more of the isoforms of AKT catalyzes the phosphorylation of FOXO1A protein at three sites, threonine-24, serine-256, and serine-319 (Zhang et al. 2002, 2006). This reaction occurs in the nucleoplasm, and thus is dependent on the phosphorylation and nuclear import of AKT in response to upstream regulatory factors (Burgering and Kops 2002).

Literature References

PubMed ID	Title	Journal	Year
16540465	Kinetic mechanism of AKT/PKB enzyme family Lofgren, JA, Yamane, H, Wahl, R, Ali, A, Zhang, S, Kendall, RL, Zhang, X	J Biol Chem	2006
12228231	Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding Unterman, TG, Gan, L, Pan, H, Zhang, X, Adam, S, Guo, S, Mesecar, A, Olson, ST, He, X	J Biol Chem	2002
12114024	Cell cycle and death control: long live Forkheads Burgering, BM, Kops, GJ	Trends Biochem Sci	2002