Reactome | HIST1H1E [nucleoplasm]

HIST1H1E [nucleoplasm]

Stable Identifier

R-HSA-211251

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

histone H1.4

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular Senescence (Homo sapiens)
    - DNA Damage/Telomere Stress Induced Senescence (Homo sapiens)
      - Formation of Senescence-Associated Heterochromatin Foci (SAHF) (Homo sapiens)
        
        SAHF formation (Homo sapiens)
        
        Histone H1 [nucleoplasm] (Homo sapiens)
        
        HIST1H1E [nucleoplasm] (Homo sapiens)
        
        Histone H1 bound chromatin DNA [nucleoplasm] (Homo sapiens)
        
        Histone H1 [nucleoplasm] (Homo sapiens)
        
        HIST1H1E [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P10412 H1-4

Gene Names

H1-4, H1F4, HIST1H1E

Chain

initiator methionine:, chain:2-219

Reference Genes

BioGPS Gene:3008 H1-4

CTD Gene:3008 H1-4

dbSNP Gene:3008 H1-4

ENSEMBL:ENSG00000168298 HIST1H1E

ENSEMBL_homo_sapiens_GENE:ENSG00000168298.7 H1-4

HGNC:4718 H1-4

KEGG Gene (Homo sapiens):3008 H1-4

Monarch:3008 H1-4

NCBI Gene:3008 H1-4

OMIM:142220 H1-4

UCSC:P10412 H1-4

Reference Transcript

RefSeq:NM_005321.2 H1-4

Other Identifiers

11734572_at

17005569

208553_PM_at

208553_at

2899172

2899173

2899174

2899175

3008

580_at

8117377

A_14_P124444

A_23_P7976

GE484924

GO:0000122

GO:0000786

GO:0000792

GO:0003677

GO:0003690

GO:0003723

GO:0005198

GO:0005515

GO:0005634

GO:0005694

GO:0006310

GO:0006325

GO:0006334

GO:0006351

GO:0006355

GO:0006357

GO:0030261

GO:0030527

GO:0031490

GO:0031492

GO:0042826

GO:0043226

GO:0045910

GO:0065003

HMNXSV003003317

ILMN_1746435

M60748_at

PH_hs_0013158

TC06000168.hg

g4885378_3p_at

Participates

as a candidate of

Histone H1 [nucleoplasm] (Homo sapiens)

Inferred To

HIST1H1E [nucleoplasm] (Danio rerio)

HHO1 [nucleoplasm] (Saccharomyces cerevisiae)

H1-4 [nucleoplasm] (Canis familiaris)

H1-4 [nucleoplasm] (Mus musculus)

H1-4 [nucleoplasm] (Rattus norvegicus)

H1 [nucleoplasm] (Dictyostelium discoideum)

si:dkey-261m9.14 [nucleoplasm] (Danio rerio)

Homologues of HIST1H1E [nucleoplasm] (Danio rerio)

histh1l1 [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_005312.1

OpenTargets

ENSG00000168298

HPA

ENSG00000168298-H1-4

GeneCards

P10412

Ensembl

ENST00000304218, ENSG00000168298, ENSP00000307705

PRO

P10412

Pharos - Targets

P10412

Orphanet

29186

PDB

7PFT, 7PEZ, 7PF6, 7PFD, 7PEX, 7PF5, 7PFX, 6H8P, 7PF0, 7PFW, 7PFC, 7PFA, 7PEU, 7PF3, 7PFV, 8H1T, 7PFU, 7PF2, 7PET, 3TZD, 7K5Y, 7K63, 7PFE, 5JJZ

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.708	5
UniProt:Q8IY81 FTSJ3	1	FTSJ3 [nucleoplasm] (R-HSA-6791507)	0.669	4
UniProt:Q9Y468 L3MBTL1	1	L3MBTL1 [nucleoplasm] (R-HSA-3222110)	0.591	7
UniProt:Q9UIG0 BAZ1B	1	BAZ1B [nucleoplasm] (R-HSA-417153)	0.564	2
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.527	2
UniProt:Q9H9L3 ISG20L2	1	ISG20L2 [nucleoplasm] (R-HSA-6799476)	0.527	2
UniProt:Q6PKG0 LARP1	1	LARP1 [cytosol] (R-HSA-9760421)	0.527	2
UniProt:Q8TBF4 ZCRB1	2	ZCRB1 [cytosol] (R-HSA-9682010) ZCRB1 [nucleoplasm] (R-HSA-6787853)	0.527	3
UniProt:O60832 DKC1	1	DKC1 [nucleoplasm] (R-HSA-163102)	0.527	2
UniProt:O96028 NSD2	2	p-S102-WHSC1 [nucleoplasm] (R-HSA-5682984) WHSC1 [nucleoplasm] (R-HSA-1183215)	0.527	2
UniProt:O43159 RRP8	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.527	3
UniProt:Q9NW13 RBM28	1	RBM28 [nucleoplasm] (R-HSA-6791192)	0.527	3
UniProt:Q53GS7 GLE1	1	GLE1 [nucleoplasm] (R-HSA-8932905)	0.527	2
UniProt:P62249 RPS16	2	RPS16 [nucleoplasm] (R-HSA-6791196) RPS16 [cytosol] (R-HSA-72337)	0.527	3
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:P05455 SSB	1	SSB [nucleoplasm] (R-HSA-58418)	0.527	2
UniProt:P15880 RPS2	3	RPS2 [nucleoplasm] (R-HSA-6790655) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [cytosol] (R-HSA-72347)	0.527	3
UniProt:O00425 IGF2BP3	1	IGF2BP3 [cytosol] (R-HSA-428313)	0.527	2
UniProt:O95363 FARS2	1	FARS2(1-?) [mitochondrial matrix] (R-HSA-379565)	0.527	2
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.527	3
UniProt:P61247 RPS3A	2	RPS3A [nucleoplasm] (R-HSA-6791182) RPS3A [cytosol] (R-HSA-72373)	0.527	2

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