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EPHA1 [plasma membrane]
Stable Identifier
R-HSA-211415
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
EphA1
Icon
Locations in the PathwayBrowser for interactor UniProt:Q02818 NUCB1
Expand all
Developmental Biology (Homo sapiens)
Transcriptional regulation of pluripotent stem cells (Homo sapiens)
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation (Homo sapiens)
Expression of EPHA1 (Homo sapiens)
EPHA1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P21709 EPHA1
Gene Names
EPHA1, EPH, EPHT, EPHT1
Chain
signal peptide:1-25, chain:26-976
Reference Genes
BioGPS Gene:2041 EPHA1
COSMIC (genes):EPHA1 EPHA1
CTD Gene:2041 EPHA1
dbSNP Gene:2041 EPHA1
ENSEMBL:ENSG00000146904 EPHA1
ENSEMBL_homo_sapiens_GENE:ENSG00000146904.9 EPHA1
ENSEMBL_homo_sapiens_GENE:ENSG00000284816.2 EPHA1
HGNC:3385 EPHA1
KEGG Gene (Homo sapiens):2041 EPHA1
Monarch:2041 EPHA1
NCBI Gene:2041 EPHA1
OMIM:179610 EPHA1
UCSC:P21709 EPHA1
Reference Transcript
RefSeq:NM_005232.4 EPHA1
Other Identifiers
1108_s_at
11723373_a_at
11751296_a_at
17063948
2041
205977_PM_s_at
205977_s_at
3077323
3077324
3077325
3077326
3077328
3077329
3077330
3077331
3077333
3077334
3077337
3077340
3077343
3077344
3077345
3077346
3077347
3077348
3077349
3077350
3077351
3077355
3077357
3077360
3077361
8143575
A_23_P157333
GE62812
GO:0000166
GO:0001525
GO:0001954
GO:0001968
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005003
GO:0005005
GO:0005515
GO:0005524
GO:0005886
GO:0006468
GO:0006469
GO:0007010
GO:0007155
GO:0007166
GO:0007169
GO:0008284
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0019901
GO:0023052
GO:0030335
GO:0030336
GO:0034446
GO:0036211
GO:0043087
GO:0043235
GO:0045766
GO:0046777
GO:0048013
GO:0048856
GO:0048870
GO:0050896
GO:0051496
GO:0060089
GO:0090630
GO:0140096
HMNXSV003006546
ILMN_1664265
M18391_s_at
PH_hs_0005023
TC07001971.hg
g4885208_3p_a_at
Participates
as a member of
EPHAs [plasma membrane] (Homo sapiens)
as an output of
Expression of EPHA1 (Homo sapiens)
Other forms of this molecule
p-Y599,Y605-EPHA1 [plasma membrane]
Inferred To
EPHA1 [plasma membrane]
(Bos taurus)
EPHA1 [plasma membrane]
(Caenorhabditis elegans)
EPHA1 [plasma membrane]
(Canis familiaris)
EPHA1 [plasma membrane]
(Danio rerio)
EPHA1 [plasma membrane]
(Drosophila melanogaster)
EPHA1 [plasma membrane]
(Gallus gallus)
EPHA1 [plasma membrane]
(Mus musculus)
EPHA1 [plasma membrane]
(Sus scrofa)
Epha1 [plasma membrane]
(Rattus norvegicus)
Homologues of EPHA1 [plasma membrane]
(Danio rerio)
Cross References
RefSeq
NP_005223.4
ZINC - World Drugs
EPHA1_HUMAN
Guide to Pharmacology - Targets
1821
OpenTargets
ENSG00000146904
ZINC - FDA approved
EPHA1_HUMAN
ZINC - Substances
EPHA1_HUMAN
ZINC target
P21709
ZINC - Biogenic
EPHA1_HUMAN
PRO
P21709
PDB
3KKA
,
2K1L
,
3HIL
,
2K1K
ZINC - Investigational
EPHA1_HUMAN
IntEnz
2.7.10.1
GeneCards
P21709
HPA
ENSG00000146904-EPHA1
Ensembl
ENSP00000494931
,
ENSG00000284816
,
ENST00000645847
,
ENST00000275815
,
ENSG00000146904
,
ENSP00000275815
Pharos - Targets
P21709
ZINC - Predictions - Purchasable
EPHA1_HUMAN
HMDB Protein
HMDBP01345
Interactors (37)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P78527 PRKDC
4
K48polyUb-PRKDC [cytosol]
(R-HSA-8938766)
PRKDC [cytosol]
(R-HSA-3134816)
p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm]
(R-HSA-76302)
PRKDC [nucleoplasm]
(R-HSA-62161)
0.615
3
UniProt:P42898 MTHFR
1
MTHFR [cytosol]
(R-HSA-200663)
0.527
2
UniProt:Q96JJ3 ELMO2
1
ELMO2 [cytosol]
(R-HSA-372642)
0.527
2
UniProt:Q96Q15 SMG1
1
SMG1 [cytosol]
(R-HSA-927760)
0.527
2
UniProt:P42695 NCAPD3
3
p-T1415,S1419-NCAPD3 [nucleoplasm]
(R-HSA-2294594)
p-T1415-NCAPD3 [nucleoplasm]
(R-HSA-2294587)
NCAPD3 [nucleoplasm]
(R-HSA-1629790)
0.527
2
UniProt:P49770 EIF2B2
1
EIF2B2 [cytosol]
(R-HSA-72519)
0.527
2
UniProt:O43432 EIF4G3
1
EIF4G3 [cytosol]
(R-HSA-1678827)
0.527
2
UniProt:Q9NRY5 FAM114A2
2
FAM114A2(1-327)-BRAF(439-766) fusion [cytosol]
(R-HSA-6802321)
FAM114A2(1-327)-p-BRAF(439-766) fusion [cytosol]
(R-HSA-6802525)
0.527
2
UniProt:Q9H1Z4 WDR13
0.527
2
UniProt:Q6NUQ1 RINT1
1
RINT1 [cytosol]
(R-HSA-6810991)
0.527
2
UniProt:Q02818 NUCB1
2
p-NUCB1 [endoplasmic reticulum lumen]
(R-HSA-8957027)
NUCB1 [endoplasmic reticulum lumen]
(R-HSA-8956751)
0.527
2
UniProt:Q7Z4Q2 HEAT3
0.527
2
UniProt:Q8N1S5 S39AB
0.527
2
UniProt:O75146 HIP1R
3
HIP1R [cytosol]
(R-HSA-8868155)
HIP1R [Golgi membrane]
(R-HSA-434348)
HIP1R [cytoplasmic vesicle membrane]
(R-HSA-434201)
0.527
2
UniProt:P50748 KNTC1
1
KNTC1 [cytosol]
(R-HSA-376233)
0.527
2
UniProt:O94768 ST17B
0.527
2
UniProt:Q86U38 NOP9
0.527
2
UniProt:Q9NR50 EIF2B3
1
EIF2B3 [cytosol]
(R-HSA-72525)
0.527
2
UniProt:O94822 LTN1
1
LTN1 [cytosol]
(R-HSA-5688967)
0.527
2
UniProt:Q96ER3 SAAL1
0.527
2
UniProt:Q9NSV4 DIAPH3
1
DIAPH3 [cytosol]
(R-HSA-5666125)
0.527
2
UniProt:Q9C0E2 XPO4
0.527
2
UniProt:Q6ZT07 TBCD9
0.527
2
UniProt:Q13144 EIF2B5
1
EIF2B5 [cytosol]
(R-HSA-72523)
0.527
2
UniProt:Q8WVM7 STAG1
4
STAG1 [cytosol]
(R-HSA-2484793)
STAG1 [chromosome]
(R-HSA-1638773)
STAG1 [nucleoplasm]
(R-HSA-163016)
STAG1 [chromosome, centromeric region]
(R-HSA-2466017)
0.527
2
UniProt:Q5JTZ9 AARS2
1
AARS2 [mitochondrial matrix]
(R-HSA-379653)
0.527
2
UniProt:Q8IYI6 EXOC8
2
EXOC8 [plasma membrane]
(R-HSA-264948)
EXOC8 [cytosol]
(R-HSA-5623388)
0.527
2
UniProt:O00471 EXOC5
2
EXOC5 [cytosol]
(R-HSA-265045)
EXOC5 [cytosol]
(R-HSA-5623383)
0.527
2
UniProt:Q15058 KIF14
1
KIF14 [cytosol]
(R-HSA-1629804)
0.527
2
UniProt:Q92538 GBF1
2
GBF1 [cytosol]
(R-HSA-6807751)
GBF1 [Golgi membrane]
(R-HSA-199994)
0.527
2
UniProt:P40855 PEX19
1
PEX19 [cytosol]
(R-HSA-3009036)
0.527
3
UniProt:O60443 GSDME
18
GSDME(1-270) G199E [cytosol]
(R-HSA-9710427)
GSDME(1-270) R48I [cytosol]
(R-HSA-9710474)
GSDME(1-270) I137T [cytosol]
(R-HSA-9710473)
GSDME W46* [cytosol]
(R-HSA-9711042)
GSDME(1-270) D18V [cytosol]
(R-HSA-9710466)
GSDME(1-270) D14Y [cytosol]
(R-HSA-9710450)
GSDME(1-270) P212L [cytosol]
(R-HSA-9710487)
GSDME(1-270) W44C [cytosol]
(R-HSA-9710470)
GSDME(1-270) I217N [cytosol]
(R-HSA-9710437)
GSDME E210* [cytosol]
(R-HSA-9710420)
GSDME(1-270) [cytosol]
(R-HSA-9647689)
GSDME [cytosol]
(R-HSA-9647620)
GSDME (271-496) [cytosol]
(R-HSA-9647615)
GSDME(1-270) E177V [cytosol]
(R-HSA-9710403)
GSDME(1-270) T196M [cytosol]
(R-HSA-9710429)
GSDME(1-270) G17D [cytosol]
(R-HSA-9710478)
GSDME(1-270) E134A [cytosol]
(R-HSA-9710410)
GSDME(1-270) N24D [cytosol]
(R-HSA-9710404)
0.527
2
UniProt:O43592 XPOT
2
XPOT [cytosol]
(R-HSA-6783484)
XPOT [nucleoplasm]
(R-HSA-6783465)
0.527
2
UniProt:P56182 RRP1
1
RRP1 [nucleoplasm]
(R-HSA-6792441)
0.527
2
UniProt:Q14012 CAMK1
2
CAMK1 [cytosol]
(R-HSA-9619207)
p-T177-CAMK1 [cytosol]
(R-HSA-9619377)
0.527
2
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.519
2
IntAct:EBI-1108795 NPM
0.499
3
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