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PAK7 [plasma membrane]
Stable Identifier
R-HSA-211555
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
PAK6
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 binds effectors at the plasma membrane (Homo sapiens)
CDC42 effectors [cytosol] (Homo sapiens)
PAK7 [plasma membrane] (Homo sapiens)
CDC42:GTP:CDC42 effectors [plasma membrane] (Homo sapiens)
CDC42 effectors [cytosol] (Homo sapiens)
PAK7 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9P286 PAK5
Gene Names
PAK5, KIAA1264, PAK7
Chain
chain:1-719
Reference Genes
BioGPS Gene:57144 PAK5
COSMIC (genes):PAK5 PAK5
CTD Gene:57144 PAK5
dbSNP Gene:57144 PAK5
ENSEMBL:ENSG00000101349 PAK5
ENSEMBL_homo_sapiens_GENE:ENSG00000101349.17 PAK5
HGNC:15916 PAK5
KEGG Gene (Homo sapiens):57144 PAK5
Monarch:57144 PAK5
NCBI Gene:57144 PAK5
OMIM:608038 PAK5
UCSC:Q9P286 PAK5
Reference Transcript
RefSeq:NM_020341.3 PAK5
RefSeq:NM_177990.2 PAK5
RefSeq:XM_017027960.1 PAK5
RefSeq:XM_017027962.1 PAK5
RefSeq:XM_017027965.1 PAK5
RefSeq:XM_017027961.1 PAK5
RefSeq:XM_017027963.1 PAK5
RefSeq:XM_017027964.1 PAK5
Other Identifiers
11730406_a_at
11739447_a_at
16917139
210721_PM_s_at
210721_s_at
213990_PM_s_at
213990_s_at
3897279
3897281
3897282
3897285
3897286
3897288
3897289
3897291
3897293
3897300
3897309
3897316
3897321
3897326
3897328
3897329
3897330
3897331
39213_at
57144
8064952
A_24_P344666
GE53856
GO:0000166
GO:0001558
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005635
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0006468
GO:0006915
GO:0007010
GO:0007165
GO:0007612
GO:0007613
GO:0007626
GO:0008283
GO:0012501
GO:0016301
GO:0016310
GO:0016477
GO:0016740
GO:0023052
GO:0031965
GO:0035556
GO:0036211
GO:0043226
GO:0043408
GO:0045202
GO:0048870
GO:0050877
GO:0106310
GO:0140096
GO:2001237
HMNXSV003003927
Hs.32539.1.S1_3p_a_at
ILMN_1770938
ILMN_1803655
PH_hs_0002749
TC20000615.hg
g7649809_3p_a_at
Participates
as a member of
CDC42 effectors [cytosol] (Homo sapiens)
Other forms of this molecule
PAK5 [cytosol]
Inferred To
PAK7 [plasma membrane]
(Bos taurus)
PAK7 [plasma membrane]
(Caenorhabditis elegans)
PAK7 [plasma membrane]
(Dictyostelium discoideum)
PAK7 [plasma membrane]
(Drosophila melanogaster)
PAK7 [plasma membrane]
(Mus musculus)
PAK7 [plasma membrane]
(Rattus norvegicus)
PAK7 [plasma membrane]
(Saccharomyces cerevisiae)
PAK7 [plasma membrane]
(Schizosaccharomyces pombe)
PAK7 [plasma membrane]
(Sus scrofa)
PAK7 [plasma membrane]
(Xenopus tropicalis)
Homologues of PAK7 [plasma membrane]
(Dictyostelium discoideum)
Homologues of PAK7 [plasma membrane]
(Saccharomyces cerevisiae)
Homologues of PAK7 [plasma membrane]
(Schizosaccharomyces pombe)
PAK5 [plasma membrane]
(Canis familiaris)
PAK5 [plasma membrane]
(Gallus gallus)
Cross References
RefSeq
XP_016883453.1
,
XP_016883451.1
,
XP_016883449.1
,
XP_016883454.1
,
XP_016883452.1
,
XP_016883450.1
,
NP_817127.1
,
NP_065074.1
ZINC - World Drugs
PAK7_HUMAN
Guide to Pharmacology - Targets
2138
OpenTargets
ENSG00000101349
ZINC - FDA approved
PAK7_HUMAN
ZINC - Substances
PAK7_HUMAN
ZINC - Biogenic
PAK7_HUMAN
ZINC target
Q9P286
PRO
Q9P286
PDB
2F57
,
8C12
ZINC - Investigational
PAK7_HUMAN
GeneCards
Q9P286
HPA
ENSG00000101349-PAK5
Ensembl
ENSP00000367679
,
ENST00000378429
,
ENSP00000322957
,
ENSP00000367686
,
ENSG00000101349
,
ENST00000378423
,
ENST00000353224
Pharos - Targets
Q9P286
ZINC - Predictions - Purchasable
PAK7_HUMAN
HMDB Protein
HMDBP01170
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P60953 CDC42
3
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
CDC42 [cytosol]
(R-HSA-442630)
CDC42 [plasma membrane]
(R-HSA-449545)
0.743
5
UniProt:P51959 CCNG1
1
CCNG1 [nucleoplasm]
(R-HSA-6792489)
0.666
4
UniProt:Q9H257 CARD9
3
CARD9 [cytosol]
(R-HSA-561194)
CARD9 [plasma membrane]
(R-HSA-5607662)
p-T231-CARD9 [plasma membrane]
(R-HSA-5607623)
0.666
5
UniProt:Q96SW2 CRBN
1
CRBN [cytosol]
(R-HSA-8863300)
0.666
4
UniProt:Q9UBK9 UXT
1
UXT [nucleoplasm]
(R-HSA-9007484)
0.666
4
UniProt:O14965 AURKA
6
SUMO1-K258-AURKA [cytosol]
(R-HSA-4655367)
p-T288-AURKA [nucleoplasm]
(R-HSA-6805089)
PolyUb-AURKA [cytosol]
(R-HSA-8854040)
AURKA [nucleoplasm]
(R-HSA-4655443)
AURKA [cytosol]
(R-HSA-174254)
p-T288-AURKA [cytosol]
(R-HSA-2574832)
0.643
3
UniProt:Q92530 PSMF1
1
PSMF1 [cytosol]
(R-HSA-68818)
0.621
3
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.564
3
UniProt:Q96BZ8 LENG1
1
LENG1 [nucleoplasm]
(R-HSA-9769590)
0.556
3
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:P48730 CSNK1D
3
CSNK1D [nucleoplasm]
(R-HSA-421305)
CSNK1D [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5685717)
CSNK1D [cytosol]
(R-HSA-380315)
0.556
3
UniProt:P16284 PECAM1
5
PECAM1 [platelet alpha granule membrane]
(R-HSA-61489)
PECAM1 [plasma membrane]
(R-HSA-114686)
PECAM1 [secretory granule membrane]
(R-HSA-6804778)
p-Y663,Y686-PECAM1(27-?) [plasma membrane]
(R-HSA-210007)
p-Y713-PECAM1 [plasma membrane]
(R-HSA-9860772)
0.556
3
UniProt:P07196 NEFL
1
NEFL [cytosol]
(R-HSA-432284)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:P53350 PLK1
4
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [cytosol]
(R-HSA-164603)
0.527
2
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