Reactome | p-5S-PAK2 [cytosol]

p-5S-PAK2 [cytosol]

Stable Identifier

R-HSA-211609

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

partially autophosphorylated full length PAK-2 (inactive)

Locations in the PathwayBrowser for interactor UniProt:Q14161 GIT2

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External Reference Information

External Reference

UniProt:Q13177 PAK2

Gene Names

PAK2

Chain

initiator methionine:, chain:2-524, chain:2-212, chain:213-524

Reference Genes

BioGPS Gene:5062 PAK2

COSMIC (genes):PAK2 PAK2

CTD Gene:5062 PAK2

dbSNP Gene:5062 PAK2

ENSEMBL:ENSG00000180370 PAK2

ENSEMBL_homo_sapiens_GENE:ENSG00000180370.10 PAK2

HGNC:8591 PAK2

KEGG Gene (Homo sapiens):5062 PAK2

Monarch:5062 PAK2

NCBI Gene:5062 PAK2

OMIM:605022 PAK2

UCSC:Q13177 PAK2

Reference Transcript

Other Identifiers

11739268_s_at

11739269_s_at

11739270_at

11739271_s_at

11739272_x_at

11739273_at

11739274_s_at

11739275_x_at

1245_i_at

1559052_PM_s_at

1559052_s_at

1560_g_at

16950017

208875_PM_s_at

208875_s_at

208876_PM_s_at

208876_s_at

208877_3p_at

208877_PM_at

208877_at

208878_PM_s_at

208878_s_at

2659578

2659584

2659585

2659586

2659587

2659588

2659589

2659591

2659593

2659594

2659597

2659600

2659601

2659602

2659603

2659604

2659605

2659606

2659607

2659608

2659609

2659610

2659611

2659612

2659613

2659614

2659630

34329_at

3612676

3612683

3612686

3612689

3612690

3612691

3612693

5062

55663_at

8084963

A_14_P125078

A_23_P327307

A_32_P104075

A_33_P3220833

GE59022

GO:0000166

GO:0002223

GO:0002376

GO:0003012

GO:0003300

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0005911

GO:0006468

GO:0006469

GO:0006915

GO:0007010

GO:0007165

GO:0008152

GO:0012501

GO:0014069

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0019901

GO:0023052

GO:0030141

GO:0030154

GO:0030296

GO:0031267

GO:0031410

GO:0034330

GO:0034333

GO:0035556

GO:0036211

GO:0042802

GO:0043066

GO:0043226

GO:0043408

GO:0045296

GO:0046777

GO:0048010

GO:0048471

GO:0048856

GO:0050731

GO:0050770

GO:0051179

GO:0051493

GO:0051497

GO:0060996

GO:0070830

GO:0071407

GO:0071560

GO:0098542

GO:0098772

GO:0098978

GO:0106310

GO:0140096

GO:0150105

GO:2001238

GO:2001271

HMNXSV003025856

Hs.284275.0.S1_3p_a_at

Hs.284275.0.S2_3p_a_at

Hs.284275.0.S4_3p_at

Hs.284275.0.S4_3p_s_at

Hs.284275.0.S4_3p_x_at

Hs.56974.0.A1_3p_s_at

Hs2.56974.1.S1_3p_s_at

ILMN_1676385

ILMN_1712687

PH_hs_0014731

TC03001100.hg

U25975_at

g5138913_3p_a_at

Participates

as an output of

Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197 (Homo sapiens)

as an input of

Cleavage of PAK-2 at 212 (Homo sapiens)

Other forms of this molecule

p-S141,T402-PAK2 [plasma membrane]

PAK2(1-524) [plasma membrane]

p-Y130,S141,T402-PAK2 [cytosol]

K48polyUb-p-T402-PAK-2p43 [cytosol]

p-T402-PAK2(213-524) [nucleoplasm]

p-T402-PAK2(213-524) [cytosol]

p-5S-PAK2(2-212) [cytosol]

p-S141,T402-PAK2 [cytosol]

PAK2 [cytosol]

PAK2(213-524) [cytosol]

Modified Residues

Name

O-phospho-L-serine at 19

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 20

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 55

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 192

Coordinate

192

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 197

Coordinate

197

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_002568.2, XP_011511172.1, XP_016861990.1

ZINC - World Drugs

PAK2_HUMAN

Guide to Pharmacology - Targets

2134

OpenTargets

ENSG00000180370

ZINC - FDA approved

PAK2_HUMAN

ZINC - Substances

PAK2_HUMAN

ZINC target

Q13177

ZINC - Biogenic

PAK2_HUMAN

PRO

Q13177

PDB

3PCS

ZINC - Investigational

PAK2_HUMAN

GeneCards

Q13177

HPA

ENSG00000180370-PAK2

Ensembl

ENSG00000180370, ENST00000327134, ENSP00000314067

Pharos - Targets

Q13177

ZINC - Predictions - Purchasable

PAK2_HUMAN

HMDB Protein

HMDBP01457

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60953 CDC42	3	CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [cytosol] (R-HSA-442630) CDC42 [plasma membrane] (R-HSA-449545)	0.874	9
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.831	5
UniProt:Q15052 ARHGEF6	1	ARHGEF6 [cytosol] (R-HSA-195017)	0.825	8
UniProt:Q14155 ARHGEF7	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.81	8
UniProt:Q9Y2X7 GIT1	2	GIT1 [cytosol] (R-HSA-430326) p-Y383-GIT1 [cytosol] (R-HSA-3928463)	0.802	5
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.8	11
UniProt:Q9H4E5 RHOJ	1	RHOJ [plasma membrane] (R-HSA-3006725)	0.782	7
UniProt:O60504 SORBS3	1	SORBS3 [cytosol] (R-HSA-445805)	0.775	6
UniProt:P16333 NCK1	2	NCK1 [cytosol] (R-HSA-197954) NCK1 [plasma membrane] (R-HSA-202992)	0.775	6
UniProt:Q9NVF7 FBX28			0.725	6
UniProt:Q14161 GIT2	1	GIT2 [cytosol] (R-HSA-446034)	0.669	3
UniProt:O55043 Arhgef7	3	p-S516-Arhgef7 [cytosol] (R-RNO-9619782) Arhgef7 [cytosol] (R-RNO-442693) Arhgef7 [cytosol] (R-RNO-430346)	0.655	8
UniProt:Q13153 PAK1	5	PAK1 [plasma membrane] (R-HSA-3928409) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) Active PAK1 [cytosol] (R-HSA-8964622) PAK1 [cytosol] (R-HSA-162629) p-S144,T423-PAK1 [cytosol] (R-HSA-399819)	0.643	4
UniProt:P55210 CASP7	5	CASP7(24-198) [nucleoplasm] (R-HSA-351927) CASP7(207-303) [nucleoplasm] (R-HSA-351924) CASP7(2-303) [cytosol] (R-HSA-57029) CASP7(24-198) [cytosol] (R-HSA-141641) CASP7(207-303) [cytosol] (R-HSA-141642)	0.619	6
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524) PAK2(1-524) [plasma membrane] (R-HSA-164946) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653)	0.602	3
UniProt:Q5PP90 Q5PP90			0.558	2
UniProt:P53667 LIMK1	3	p-S,T508-LIMK1 [cytosol] (R-HSA-419610) p-T508-LIMK1 [cytosol] (R-HSA-399816) LIMK1 [cytosol] (R-HSA-397785)	0.558	2
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.558	2
UniProt:Q9NYB9-2 ABI2			0.556	3
UniProt:O60711 LPXN			0.527	2
UniProt:O60404 OR10H3	1	OR10H3 [endoplasmic reticulum membrane] (R-HSA-9751545)	0.527	2
UniProt:P05362 ICAM1	1	ICAM1 [plasma membrane] (R-HSA-197683)	0.527	2
UniProt:Q9BTV5 FSD1			0.527	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	4
UniProt:P02675 FGB	5	FGB(31-491) [platelet alpha granule lumen] (R-HSA-140921) FGB(31-491) [extracellular region] (R-HSA-140846) FGB [plasma membrane] (R-HSA-140917) FGB(31-44) [extracellular region] (R-HSA-140876) FGB [extracellular region] (R-HSA-140584)	0.527	2
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.527	2
UniProt:Q8WVK2 SNRNP27	1	SNRNP27 [nucleoplasm] (R-HSA-6806778)	0.527	2
UniProt:P48431 SOX2	1	SOX2 [nucleoplasm] (R-HSA-452271)	0.527	2
UniProt:Q92845 KIFAP3	3	KIFAP3 [cytosol] (R-HSA-984736) KIFAP3 [cilium] (R-HSA-5624882) KIFAP3 [ciliary tip] (R-HSA-5625382)	0.527	2
UniProt:Q9NYY3 PLK2	1	PLK2 [cytosol] (R-HSA-6801636)	0.527	2
UniProt:O94875 SRBS2			0.524	2
UniProt:Q8TEJ3 SH3R3			0.524	2
UniProt:Q9BX66 SORBS1	1	SORBS1 [cytosol] (R-HSA-445795)	0.524	2
UniProt:P08631 HCK	2	p-HCK [cytosol] (R-HSA-9676060) HCK [cytosol] (R-HSA-167708)	0.524	2
UniProt:P12931 SRC	6	p-Y419-SRC [nucleoplasm] (R-HSA-8937690) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.524	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.524	2

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