Reactome | CYP26C1 4-hydroxylates 9cRA

CYP26C1 4-hydroxylates 9cRA

Stable Identifier

R-HSA-211923

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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Endogenous retinoic acids (RA) which play a role in gene regulation exist as either cis or trans isomers. While CYP26C1 can also hydroxylate the trans form, it is unique in 4-hydroxylating the 9-cis isomer of RA (9cRA) in vitro (Taimi et al. 2004). However, the importance of 9cRA as an endogenous retinoid outside of the pancreas has not been demonstrated.

Literature References

PubMed ID	Title	Journal	Year
14532297	A novel human cytochrome P450, CYP26C1, involved in metabolism of 9-cis and all-trans isomers of retinoic acid White, J, Taimi, M, Helvig, C, Petkovich, M, Ramshaw, H, Korczak, B, Amad, M, Wisniewski, J	J Biol Chem	2004