Reactome | CYP24A1 24-hydroxylates CTL

CYP24A1 24-hydroxylates CTL

Stable Identifier

R-HSA-211950

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix, mitochondrial inner membrane

Synonyms

CYP24A1 catalyzes the initial step in the deactivation of the hormonally active form of vitamin D3

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Catabolic inactivation of the active, hormonal form of vitamin D3 (1,25-dihydroxyvitamin D3, calcitriol, CTL) is initially carried out by 24-hydroxylation, mediated by CYP24A1 (1,25-dihydroxyvitamin D3 24-hydroxylase). The product formed is eventually transformed to calcitroic acid (CTLA), the major water-soluble metabolite that can be excreted in bile.

Literature References

PubMed ID	Title	Journal	Year
8679605	Human 25-hydroxyvitamin D3-24-hydroxylase, a multicatalytic enzyme Beckman, MJ, DeLuca, HF, Yamada, S, Prahl, J, Tadikonda, P, Werner, E	Biochemistry	1996
17646648	Single A326G mutation converts human CYP24A1 from 25-OH-D3-24-hydroxylase into -23-hydroxylase, generating 1alpha,25-(OH)2D3-26,23-lactone Prosser, DE, Kaufmann, M, Byford, V, Jones, G, O'Leary, B	Proc Natl Acad Sci U S A	2007
11012668	Dual metabolic pathway of 25-hydroxyvitamin D3 catalyzed by human CYP24 Komai, K, Sawada, N, Ohyama, Y, Shiozawa, S, Sakaki, T, Yamada, S, Inouye, K, Yamamoto, K	Eur J Biochem	2000