Reactome | HIST1H3A [nucleoplasm]

HIST1H3A [nucleoplasm]

Stable Identifier

R-HSA-212070

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone H3.1, Histone H3a, Histone H3b, Histone H3c, Histone H3d, Histone H3f, Histone H3h, Histone H3i, Histone H3j, Histone H3k, Histone H3l

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of programmed cell death (Homo sapiens)
  - Defective pyroptosis (Homo sapiens)
    - The GSDME gene promoter is hypermethylated (Homo sapiens)
      - DNMT1,3A,3B:PRC2:Chromatin [nucleoplasm] (Homo sapiens)
        
        PRC2 Core:Chromatin [nucleoplasm] (Homo sapiens)
        
        Chromatin [nucleoplasm] (Homo sapiens)
        
        Nucleosome [nucleoplasm] (Homo sapiens)
        
        Histone H3 [nucleoplasm] (Homo sapiens)
        
        HIST1H3A [nucleoplasm] (Homo sapiens)
- Infectious disease (Homo sapiens)
  - HCMV Infection (Homo sapiens)
    - HCMV Early Events (Homo sapiens)
      - Activation of Latent HCMV Genome (Homo sapiens)
        
        Latent Transcriptionally Repressed HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Core histone octamer [nucleoplasm] (Homo sapiens)
        
        Histone H3:H4 tetramer [nucleoplasm] (Homo sapiens)
        
        Histone H3 [nucleoplasm] (Homo sapiens)
        
        HIST1H3A [nucleoplasm] (Homo sapiens)
      - Latent Transcriptinally Repressed HCMV Genome (Homo sapiens)
        
        Core histone octamer [nucleoplasm] (Homo sapiens)
        
        Histone H3:H4 tetramer [nucleoplasm] (Homo sapiens)
        
        Histone H3 [nucleoplasm] (Homo sapiens)
        
        HIST1H3A [nucleoplasm] (Homo sapiens)
        
        Latent Transcriptionally Repressed HCMV Genome [nucleoplasm] (Homo sapiens)
        
        Core histone octamer [nucleoplasm] (Homo sapiens)
        
        Histone H3:H4 tetramer [nucleoplasm] (Homo sapiens)
        
        Histone H3 [nucleoplasm] (Homo sapiens)
        
        HIST1H3A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P68431 H3C1

Gene Names

H3C1, H3FA, HIST1H3A, H3C2, H3FL, HIST1H3B, H3C3, H3FCHIST1H3C, H3C4, H3FB, HIST1H3D, H3C6, H3FD, HIST1H3E, H3C7, H3FI, HIST1H3F, H3C8, H3FH, HIST1H3G, H3C10, H3FK, HIST1H3H, H3C11, H3FF, HIST1H3I, H3C12, H3FJ, HIST1H3J

Chain

initiator methionine:1, chain:2-136

Reference Genes

BioGPS Gene:8350 H3C1

BioGPS Gene:8351 H3C1

BioGPS Gene:8352 H3C1

BioGPS Gene:8353 H3C1

BioGPS Gene:8354 H3C1

BioGPS Gene:8355 H3C1

BioGPS Gene:8356 H3C1

BioGPS Gene:8357 H3C1

BioGPS Gene:8358 H3C1

BioGPS Gene:8968 H3C1

CTD Gene:8350 H3C1

CTD Gene:8351 H3C1

CTD Gene:8352 H3C1

CTD Gene:8353 H3C1

CTD Gene:8354 H3C1

CTD Gene:8355 H3C1

CTD Gene:8356 H3C1

CTD Gene:8357 H3C1

CTD Gene:8358 H3C1

CTD Gene:8968 H3C1

dbSNP Gene:8350 H3C1

dbSNP Gene:8351 H3C1

dbSNP Gene:8352 H3C1

dbSNP Gene:8353 H3C1

dbSNP Gene:8354 H3C1

dbSNP Gene:8355 H3C1

dbSNP Gene:8356 H3C1

dbSNP Gene:8357 H3C1

dbSNP Gene:8358 H3C1

dbSNP Gene:8968 H3C1

ENSEMBL:ENSG00000197153 HIST1H3J

ENSEMBL:ENSG00000197409 HIST1H3D

ENSEMBL:ENSG00000273983 HIST1H3G

ENSEMBL:ENSG00000274750 HIST1H3E

ENSEMBL:ENSG00000275379 HIST1H3I

ENSEMBL:ENSG00000275714 HIST1H3A

ENSEMBL:ENSG00000277775 HIST1H3A

ENSEMBL:ENSG00000278828 HIST1H3H

ENSEMBL:ENSG00000286522 H3C1

ENSEMBL:ENSG00000287080 H3C1

HGNC:4766 H3C1

HGNC:4767 H3C1

HGNC:4768 H3C1

HGNC:4769 H3C1

HGNC:4771 H3C1

HGNC:4772 H3C1

HGNC:4773 H3C1

HGNC:4774 H3C1

HGNC:4775 H3C1

HGNC:4776 H3C1

KEGG Gene (Homo sapiens):8350 H3C1

KEGG Gene (Homo sapiens):8351 H3C1

KEGG Gene (Homo sapiens):8352 H3C1

KEGG Gene (Homo sapiens):8353 H3C1

KEGG Gene (Homo sapiens):8354 H3C1

KEGG Gene (Homo sapiens):8355 H3C1

KEGG Gene (Homo sapiens):8356 H3C1

KEGG Gene (Homo sapiens):8357 H3C1

KEGG Gene (Homo sapiens):8358 H3C1

KEGG Gene (Homo sapiens):8968 H3C1

Monarch:8350 H3C1

Monarch:8351 H3C1

Monarch:8352 H3C1

Monarch:8353 H3C1

Monarch:8354 H3C1

Monarch:8355 H3C1

Monarch:8356 H3C1

Monarch:8357 H3C1

Monarch:8358 H3C1

Monarch:8968 H3C1

NCBI Gene:8350 H3C1

NCBI Gene:8351 H3C1

NCBI Gene:8352 H3C1

NCBI Gene:8353 H3C1

NCBI Gene:8354 H3C1

NCBI Gene:8355 H3C1

NCBI Gene:8356 H3C1

NCBI Gene:8357 H3C1

NCBI Gene:8358 H3C1

NCBI Gene:8968 H3C1

OMIM:602810 H3C1

OMIM:602811 H3C1

OMIM:602812 H3C1

OMIM:602813 H3C1

OMIM:602814 H3C1

OMIM:602815 H3C1

OMIM:602816 H3C1

OMIM:602817 H3C1

OMIM:602818 H3C1

OMIM:602819 H3C1

UCSC:P68431 H3C1

Reference Transcript

Other Identifiers

0000580463

0001740113

0001990020

0002370435

0004210524

0004760253

0005910408

0006040088

0006620279

0006840746

11715100_at

11715101_s_at

11715102_x_at

11715121_s_at

11732103_s_at

11732968_at

11733426_at

11734573_at

11734574_x_at

11738783_at

11740594_s_at

11741186_at

11741809_at

11759077_at

11759374_at

17005532

17005539

17005593

17005862

17016363

17016400

17016403

17016503

17016509

206110_at

208496_x_at

208506_at

208575_at

208576_s_at

208577_at

214472_at

214509_at

214616_at

236278_at

2899091

2899092

2899093

2899094

2899104

2899234

2899235

2899236

2899237

2899238

2899239

2899240

2900052

2900053

2900054

2946216

2946217

2946218

2946327

2946328

2946329

2946365

2946366

2946370

2946371

2946372

2946374

2947078

2947079

2947096

2947097

2947098

33018_at

34964_at

35598_at

36757_at

47803_at

8117330

8117339

8117415

8117589

8124388

8124437

8124440

8124531

8124537

8350

8351

8352

8353

8354

8355

8356

8357

8358

8968

ADDON002433.hg

ADDON002456.hg

ADDON002746.hg

A_14_P111746

A_14_P120482

A_14_P138808

A_23_P111037

A_23_P133814

A_23_P219045

A_23_P30799

A_23_P333484

A_23_P42198

A_23_P70445

A_23_P93258

A_23_P93282

A_24_P174924

A_24_P217834

A_24_P9321

A_32_P794894

A_33_P3287879

A_33_P3404989

GE531056

GE561628

GE562418

GE61638

GE62561

GE81296

GE81297

GE85687

GE862238

GE88856

GO:0000183

GO:0000228

GO:0000786

GO:0002376

GO:0003674

GO:0003677

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0006325

GO:0006334

GO:0006335

GO:0006950

GO:0007165

GO:0007596

GO:0008150

GO:0009058

GO:0016020

GO:0022607

GO:0030154

GO:0032200

GO:0032991

GO:0034641

GO:0038111

GO:0043226

GO:0044267

GO:0045296

GO:0045652

GO:0045814

GO:0046982

GO:0048856

GO:0051276

GO:0060964

GO:0060968

GO:0065003

GO:0070062

HMNXSV003001551

HMNXSV003020607

HMNXSV003022329

HMNXSV003025282

HMNXSV003028444

HMNXSV003035115

HMNXSV003040184

HMNXSV003043869

HMNXSV003045300

HMNXSV003052745

Hs.132854.0.S1_3p_at

Hs.143522.0.S2_3p_at

Hs.239458.0.S1_3p_s_at

Hs.293557.0.A1_3p_at

ILMN_1698417

ILMN_1707257

ILMN_1712184

ILMN_1721127

ILMN_1726815

ILMN_1742688

ILMN_1749368

ILMN_1752063

ILMN_1776845

ILMN_1788489

ILMN_1881081

ILMN_1914800

ILMN_2207865

ILMN_2222163

ILMN_3235949

M60746_at

PH_hs_0013175

PH_hs_0029469

PH_hs_0029487

PH_hs_0031294

PH_hs_0032264

PH_hs_0032298

PH_hs_0032314

PH_hs_0036082

PH_hs_0038412

PH_hs_0039056

TC06000162.hg

TC06000164.hg

TC06000174.hg

TC06001342.hg

TC06001353.hg

TC06001354.hg

TC06001427.hg

TC06001429.hg

TC06004064.hg

X00090_f_at

Z80777_at

Z83735_at

g10440559_3p_at

g4504280_3p_at

g4504280_3p_x_at

g4504284_3p_at

g4504290_3p_at

g4504290_3p_x_at

g4504294_3p_at

g4504296_3p_s_at

Participates

as a candidate of

as a member of

Histone H3 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

HIST1H3A [extracellular region]

2xAcK-HIST1H3A [nucleoplasm]

Ack-Me3K5-HIST1H3A [nucleoplasm]

AcK-Me3K10-HIST1H3A [nucleoplasm]

AcK-Me3K28-HIST1H3A [nucleoplasm]

AcK19-HIST1H3A [nucleoplasm]

AcK5-HIST1H3A [nucleoplasm]

AcK24-HIST1H3A [nucleoplasm]

AcK15-HIST1H3A [nucleoplasm]

Ack15-HIST1H3A [nucleoplasm]

Me2aR27-HIST1H3A [nucleoplasm]

MeR27-HIST1H3A [nucleoplasm]

Me2aR18-HIST1H3A [nucleoplasm]

Me2sR9-HIST1H3A [nucleoplasm]

Me2sR3-HIST1H3A [nucleoplasm]

AcK9,14-p-S10-HIST1H3A [nucleoplasm]

AcK14,18,79-p-S10-HIST1H3A [nucleoplasm]

AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm]

AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm]

AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]

AcK14,18-p-S10-HIST1H3A [nucleoplasm]

AcK14,18,79-p-T11-HIST1H3A [nucleoplasm]

AcK14,18-p-T11-HIST1H3A [nucleoplasm]

AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]

Me3K10-HIST1H3A [nucleoplasm]

Me3K28-HIST1H3A [nucleoplasm]

Me2K28-HIST1H3A [nucleoplasm]

MeK37-HIST1H3A [nucleoplasm]

MeK80-HIST1H3A [nucleoplasm]

Me3K80-HIST1H3A [nucleoplasm]

Me2K80-HIST1H3A [nucleoplasm]

Me3K37-HIST1H3A [nucleoplasm]

Me2K37-HIST1H3A [nucleoplasm]

MeK10-HIST1H3A [nucleoplasm]

MeK28-HIST1H3A [nucleoplasm]

MeK-10-HIST1H3A [cytosol]

HIST1H3A [cytosol]

Me2aR3-HIST1H3A [nucleoplasm]

MeK5-HIST1H3A [nucleoplasm]

Cit27-HIST1H3A [nucleoplasm]

Cit3-HIST1H3A [nucleoplasm]

Cit9-HIST1H3A [nucleoplasm]

Cit18-HIST1H3A [nucleoplasm]

MeR18-HIST1H3A [nucleoplasm]

MeR3-HIST1H3A [nucleoplasm]

MeR27-HIST1H3A [nucleoplasm]

MeR9-HIST1H3A [nucleoplasm]

Ack10-HIST1H3A [nucleoplasm]

Me2K5,Me2aR3-HIST1H3A [nucleoplasm]

Me2K10-HIST1H3A [nucleoplasm]

p-T12-HIST1H3A [nucleoplasm]

p-T12,MeK-10-HIST1H3A [nucleoplasm]

Me3K-10-HIST1H3A [nucleoplasm]

p-T12, Me3K-10-HIST1H3A [nucleoplasm]

p-T12, Me2K-10-HIST1H3A [nucleoplasm]

Me3K5-HIST1H3A [nucleoplasm]

Me3K-28-HIST1H3A [nucleoplasm]

Me2K5-HIST1H3A [nucleoplasm]

Inferred To

cnp1 [nucleoplasm] (Schizosaccharomyces pombe)

HIST1H3A [nucleoplasm] (Bos taurus)

HIST1H3A [nucleoplasm] (Danio rerio)

HIST1H3A [nucleoplasm] (Xenopus tropicalis)

histone H3.1 [nucleoplasm] (Rattus norvegicus)

HIST1H3E [nucleoplasm] (Sus scrofa)

H3v1 [nucleoplasm] (Dictyostelium discoideum)

his-40 [nucleoplasm] (Caenorhabditis elegans)

CSE4 [nucleoplasm] (Saccharomyces cerevisiae)

H3C6 [nucleoplasm] (Canis familiaris)

Histone H3.1 [nucleoplasm] (Mus musculus)

Homologues of HIST3H3 [nucleoplasm] (Plasmodium falciparum)

HIST3H3 [nucleoplasm] (Plasmodium falciparum)

Cross References

RefSeq

NP_003525.1, NP_003521.2, NP_003524.1, NP_003527.1, NP_066298.1, NP_003526.1, NP_003520.1, NP_003528.1, NP_003523.1, NP_003522.1

Target Pathogen

57cdcfdfbe737e0b49b9a3bb, 5b2801b2be737e35a6de9484, 5b2801b2be737e35a6dea8d6, 57c5eaa7be737e5a0cb4f982, 5b2801b3be737e35a6dee562, 5b354852be737e166372eaa2, 5b354852be737e166372e957, 5b354852be737e166372eb9b, 57c08b76be737e1cc0a95c6a, 5b2801b2be737e35a6de88ae, 5b2801b3be737e35a6df1873, 57c0aa24be737e1cc0a9c2e3, 5b2801b3be737e35a6df0c8a, 5b2801b3be737e35a6df0ac2, 5b2801b3be737e35a6df0ddc, 57c0ab45be737e1cc0a9d2f0, 5b2801b2be737e35a6dea64d, 5b2801b3be737e35a6deea80, 5b354852be737e166372e85a, 57c0ab9bbe737e1cc0a9d7f0, 57c5e634be737e5a0cb4cb11, 5b2801b2be737e35a6dea9b5, 5b354852be737e166372eaa9

OpenTargets

ENSG00000275714

GeneCards

P68431

HPA

ENSG00000278272-HIST1H3C, ENSG00000275714-HIST1H3A, ENSG00000197409-HIST1H3D, ENSG00000275379-HIST1H3I, ENSG00000273983-HIST1H3G, ENSG00000197153-HIST1H3J, ENSG00000274267-HIST1H3B, ENSG00000277775-HIST1H3F, ENSG00000278828-HIST1H3H, ENSG00000274750-HIST1H3E

Ensembl

ENSG00000286522, ENSG00000197153, ENSG00000274750, ENSP00000489282, ENSP00000480826, ENST00000618052, ENSG00000273983, ENSG00000197409, ENSG00000275379, ENST00000616365, ENST00000369163, ENSP00000484841, ENSG00000275714, ENSG00000277775, ENSP00000358160, ENSP00000366999, ENSP00000484638, ENST00000621411, ENSP00000484658, ENST00000613854, ENSP00000352252, ENST00000612966, ENSG00000278828, ENSP00000482271, ENSP00000483283, ENSP00000484095, ENSG00000287080, ENST00000614911, ENST00000614378, ENST00000634733, ENST00000359303, ENST00000356476

PRO

P68431

PDB

6R90, 3U4S, 5HJB, 3O35, 2NDG, 6K1I, 2X0L, 6WAV, 5H6Q, 5HJD, 3SOW, 5V21, 5FB0, 5WVO, 4LKA, 5NND, 5AV8, 5B24, 6IQ4, 6E86, 5GSE, 2CV5, 5T0K, 4X3K, 6KE9, 3ZVY, 6L49, 6MIO, 2FSA, 6MIL, 5J3V, 5M5G, 5AVB, 6YOV, 5GT0, 6WW4, 3X1U, 3AZN, 5VA6, 6BHH, 6V2H, 3U5P, 5FFV, 3UIG, 6VIL, 2KWK, 2B2V, 2OT7, 2RI7, 6K1K, 3AZK, 5CPK, 3V43, 2CO0, 3MP1, 2C1J, 6HKT, 5TDW, 5KJH, 2B2T, 5Y20, 3LQI, 6UPK, 6LE9, 2V89, 5X60, 2VNF, 4C1Q, 5SVX, 5SZC, 3O37, 2V85, 5TBN, 5C3I, 5SVY, 5WLE, 7CCR, 4QBS, 5GT3, 3B95, 5XFQ, 5VGE, 5AV5, 5DAH, 6JR1, 3AFA, 6V3N, 3FDT, 3X1S, 5Y2F, 6R8Y, 3W99, 6T90, 1O9S, 3ZG6, 3W97, 5WYI, 6M3V, 6IEU, 5T0M, 4TN7, 6R93, 5GH9, 2OQ6, 2RR4, 4UP0, 6MIM, 6BHI, 3AZE, 5B31, 4LXL, 3AZM, 5CPI, 5WFC, 5Y0C, 4YHZ, 4YM5, 3WA9, 4UY4, 3UEF, 6AZE, 6UPL, 5Z30, 5C13, 6M4D, 1CS9, 5XF5, 3RIG, 5JIN, 3AZH, 4N4H, 4QBQ, 4Z2M, 6BHE, 6JXD, 5J9S, 6YIF, 6V41, 2L75, 5JIY, 6R91, 3O34, 2B2W, 5IQL, 2NDF, 4BD3, 4LK9, 6T93, 6M4G, 5KKL, 5LUG, 5NNC, 3SOU, 5H6R, 6R94, 5XNV, 5AV9, 3QJ6, 5V22, 4FWF, 4A0N, 6BHG, 3KQI, 6IIS, 5B2I, 5GSU, 2VPG, 3WKJ, 6K1J, 5WXG, 6USJ, 5AVC, 6KVD, 3X1T, 4A0J, 4LLB, 4Y6L, 3UII, 6LA8, 4F4U, 4U68, 3U5O, 6L4A, 6MIQ, 5CPJ, 6D07, 4A7J, 5VAB, 2B2U, 6L9H, 7C0M, 5XF3, 3AZJ, 1Q3L, 2KWJ, 5KJI, 5VNB, 4L7X, 3U3D, 3AZG, 6M4H, 3UIK, 6R8Z, 3AZF, 5JJ0, 4F56, 3AVR, 4QBR, 6HTS, 5JHN, 2LBM, 5JRG, 2UXN, 3U31, 6E83, 5AV6, 6JR0, 5GTC, 5WXH, 6AXJ, 1CT6, 3W98, 6V92, 6MIN, 5FB1, 6IPU, 5OY3, 5XFR, 2LGG, 6F6D, 6M44, 6R92, 6YIH, 3W96, 3KMT, 3X1V, 2M0O, 5MR8, 4Z0R, 5B2J, 5Z23, 5Y0D, 4HON, 5D6Y, 5T8R, 4YHP, 6IIT, 5HJC, 3WAA, 4I51, 3AZL, 2C1N, 7CCQ, 2OX0, 5TDR, 3AYW, 4YM6, 6JOU, 3RIY, 5T1G, 5C11, 3UEE, 5T1I, 5U2J, 6BHD, 3U5N, 3LQJ, 5SZB, 5XTZ, 6D08, 3AZI, 3A1B, 5HYN, 5XF4, 6LA9

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62805 H4C1	19	SUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) HIST1H4A [extracellular region] (R-HSA-977569) SUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-4568749) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) MeK-HIST1H4A [nucleoplasm] (R-HSA-2172676) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652)	0.891	7
UniProt:Q9Y294 ASF1A	1	ASF1A [nucleoplasm] (R-HSA-417169)	0.848	9
UniProt:P83916 CBX1	1	CBX1 [nucleoplasm] (R-HSA-9653629)	0.834	13
UniProt:P45973 CBX5	2	SUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849) CBX5 [nucleoplasm] (R-HSA-994093)	0.811	10
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.788	5
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.74	11
UniProt:Q13185 CBX3	1	CBX3 [nucleoplasm] (R-HSA-427386)	0.713	6
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.703	20
UniProt:Q03164 KMT2A	1	KMT2A [nucleoplasm] (R-HSA-1183223)	0.675	11
UniProt:Q9BVI0 PHF20	3	p-S291-PHF20 [nucleoplasm] (R-HSA-6805776) p-S291-PHF20 [cytosol] (R-HSA-6805794) PHF20 [nucleoplasm] (R-HSA-3222239)	0.655	6
UniProt:Q12888 TP53BP1	3	TP53BP1 [nucleoplasm] (R-HSA-61175) SUMO1-K-TP53BP1 [nucleoplasm] (R-HSA-2997591) p-S25,S1778-TP53BP1 [nucleoplasm] (R-HSA-5683418)	0.655	5
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.643	3
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.643	3
UniProt:P38991	2	IPL1 [cytosol] (R-SCE-174254) IPL1 [cytosol] (R-SCE-8854040)	0.623	2
UniProt:P49736 MCM2	1	MCM2 [nucleoplasm] (R-HSA-68557)	0.623	6
UniProt:Q61686 Cbx5	2	Cbx5 [nucleoplasm] (R-MMU-4616022) Sumo1-K84,K-Cbx5 [nucleoplasm] (R-MMU-4615870)	0.609	2
UniProt:Q8VDF2 Uhrf1	1	Uhrf1 [nucleoplasm] (R-MMU-5336220)	0.581	3
UniProt:Q9Y5B9 SUPT16H	1	SUPT16H [nucleoplasm] (R-HSA-112415)	0.569	3
UniProt:Q9Y468 L3MBTL1	1	L3MBTL1 [nucleoplasm] (R-HSA-3222110)	0.558	2
UniProt:Q8WUP2 FBLIM1	1	FBLIM1 [cytosol] (R-HSA-430301)	0.556	3
UniProt:P54252 ATXN3	2	ATXN3 [cytosol] (R-HSA-5625607) ATXN3 [nucleoplasm] (R-HSA-6783285)	0.556	3
UniProt:P37840 SNCA	4	SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569) SNCA [cytosol] (R-HSA-5658500) Ub-SNCA [cytosol] (R-HSA-5660754)	0.556	3
UniProt:O76024 WFS1	3	p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q9UNP9 PPIE	4	PPIE [ficolin-1-rich granule lumen] (R-HSA-6801393) PPIE [nucleoplasm] (R-HSA-6781959) PPIE [extracellular region] (R-HSA-6806493) PPIE [secretory granule lumen] (R-HSA-6801369)	0.544	3
UniProt:Q9NPI1 BRD7	1	BRD7 [nucleoplasm] (R-HSA-3222092)	0.536	2
UniProt:P51858 HDGF	1	HDGF [nucleoplasm] (R-HSA-535593)	0.483	4
UniProt:P09429 HMGB1	5	HC23,45-HMGB1 [extracellular region] (R-HSA-6797422) HMGB1 [ficolin-1-rich granule lumen] (R-HSA-6803291) HMGB1 [nucleoplasm] (R-HSA-266221) HMGB1 [extracellular region] (R-HSA-879382) HMGB1 [secretory granule lumen] (R-HSA-6803337)	0.483	2
UniProt:P09874 PARP1	4	SUMO1-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551686) SUMO2,3-K203,K486-PARP1 [nucleoplasm] (R-HSA-4551617) PAR-PARP1 [nucleoplasm] (R-HSA-5651713) PARP1 [nucleoplasm] (R-HSA-201568)	0.483	3
UniProt:P35659 DEK	1	DEK [nucleoplasm] (R-HSA-5250643)	0.483	2
UniProt:Q08945 SSRP1	1	SSRP1 [nucleoplasm] (R-HSA-65105)	0.483	2
UniProt:P78527 PRKDC	4	PRKDC [cytosol] (R-HSA-3134816) K48polyUb-PRKDC [cytosol] (R-HSA-8938766) PRKDC [nucleoplasm] (R-HSA-62161) p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm] (R-HSA-76302)	0.483	2