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EHMT2 [nucleoplasm]
Stable Identifier
R-HSA-212151
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
G9a, Histone Methyltransferase G9a, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, KMT1C
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)
Cdh1:APC/C complex binds EHMT1:EHMT2 (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
Cdh1:APC/C ubiquitinates EHMT1 and EHMT2 (Homo sapiens)
EHMT1:EHMT2:Cdh1:p-APC/C [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
Ub-EHMT1:Ub-EHMT2:Cdh1:p-APC/C [nucleoplasm] (Homo sapiens)
Ub-EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 methylates IL6 promoter (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 methylates IL8 promoter (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
Regulation of IL6 transcription (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
Stimulation of IL8 transcription in senescent cells (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
PKMTs methylate histone lysines (Homo sapiens)
EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9) (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9) (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Positive epigenetic regulation of rRNA expression (Homo sapiens)
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression (Homo sapiens)
Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9. (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
RNA Polymerase I Transcription (Homo sapiens)
RNA Polymerase I Promoter Clearance (Homo sapiens)
RNA Polymerase I Transcription Initiation (Homo sapiens)
Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Homo sapiens)
TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by E2F6 (Homo sapiens)
CBX3 and PRC1.6 associate with E2F6.com-1 (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
E2F1 gene transcription is inhibited by E2F6 (Homo sapiens)
E2F6:TFDP1/2,(E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6) [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6:E2F1 gene [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
E2F6.com-1 complex binds the E2F1 gene promoter (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6:E2F1 gene [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2:CBX3:PRC1.6 [nucleoplasm] (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 complex binds E2F6.com-1 core (Homo sapiens)
E2F6:TFDP1:MGA:MAX:EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Methylation (Homo sapiens)
EHMT1:EHMT2 dimethylates TP53 (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
Transcriptional Regulation by VENTX (Homo sapiens)
Regulation of IL6 transcription (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
Sensory Perception (Homo sapiens)
Olfactory Signaling Pathway (Homo sapiens)
Expression and translocation of olfactory receptors (Homo sapiens)
Expression of Olfactory Receptor (Homo sapiens)
EHMT2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96KQ7 EHMT2
Gene Names
EHMT2, BAT8, C6orf30, G9A, KMT1C, NG36
Chain
initiator methionine:1, chain:2-1210
Reference Genes
BioGPS Gene:10919 EHMT2
COSMIC (genes):EHMT2 EHMT2
CTD Gene:10919 EHMT2
dbSNP Gene:10919 EHMT2
ENSEMBL:ENSG00000204371 EHMT2
ENSEMBL:ENSG00000204371.11 EHMT2
ENSEMBL:ENSG00000206376.9 EHMT2
ENSEMBL:ENSG00000227333.8 EHMT2
ENSEMBL:ENSG00000232045.7 EHMT2
ENSEMBL:ENSG00000236759.7 EHMT2
ENSEMBL:ENSG00000238134.8 EHMT2
HGNC:14129 EHMT2
KEGG Gene (Homo sapiens):10919 EHMT2
Monarch:10919 EHMT2
NCBI Gene:10919 EHMT2
OMIM:604599 EHMT2
UCSC:Q96KQ7 EHMT2
Reference Transcript
RefSeq:NM_001289413.1 EHMT2
RefSeq:NM_001318833.1 EHMT2
RefSeq:NM_006709.4 EHMT2
RefSeq:NM_025256.6 EHMT2
Other Identifiers
0002340390
0006370112
10919
11732391_a_at
17017536
17026916
17029389
17032175
17036882
17039625
17042143
202326_PM_at
202326_at
207484_PM_s_at
207484_s_at
2949525
2949526
2949527
2949528
2949530
2949531
2949532
2949533
2949534
2949535
2949536
2949538
2949539
2949542
2949543
2949545
2949547
2949548
2949549
2949550
2949551
2949552
2949553
2949554
2949555
2949556
2949557
2949558
2949559
2949562
2949563
2949564
2949567
36200_at
8125172
8179884
A_23_P214638
A_24_P303390
GE59963
GO:0000122
GO:0000785
GO:0000977
GO:0001222
GO:0002039
GO:0003677
GO:0005515
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0006260
GO:0006275
GO:0006306
GO:0006325
GO:0006351
GO:0006355
GO:0006357
GO:0006914
GO:0007059
GO:0007130
GO:0007286
GO:0007616
GO:0008168
GO:0008270
GO:0009267
GO:0009566
GO:0010424
GO:0016279
GO:0016571
GO:0016607
GO:0016740
GO:0018024
GO:0018027
GO:0022414
GO:0030154
GO:0031667
GO:0032259
GO:0034968
GO:0035265
GO:0036166
GO:0036211
GO:0043226
GO:0044030
GO:0045471
GO:0046872
GO:0046974
GO:0046976
GO:0048148
GO:0048599
GO:0048665
GO:0048856
GO:0050877
GO:0051567
GO:0051569
GO:0051570
GO:0060992
GO:0070734
GO:0070742
GO:0071314
GO:0071466
GO:0140013
GO:0140096
GO:1902902
GO:1990841
HMNXSV003058422
ILMN_1700791
ILMN_1751081
PH_hs_0004285
TC06001550.hg
TC6_apd_hap1000091.hg
TC6_cox_hap2000177.hg
TC6_dbb_hap3000166.hg
TC6_mcf_hap5000152.hg
TC6_qbl_hap6000167.hg
TC6_ssto_hap7000146.hg
X69838_at
g13376865_3p_at
g13376865_3p_x_at
g5729833_3p_at
Participates
as an input of
Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene (Homo sapiens)
as a component of
TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Homo sapiens)
Ub-EHMT2 [nucleoplasm] (Homo sapiens)
EHMT1:EHMT2 [nucleoplasm] (Homo sapiens)
Inferred To
Ghost homologue of EHMT2 [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of EHMT2 [nucleoplasm]
(Gallus gallus)
EHMT2 [nucleoplasm]
(Bos taurus)
EHMT2 [nucleoplasm]
(Canis familiaris)
EHMT2 [nucleoplasm]
(Danio rerio)
EHMT2 [nucleoplasm]
(Mus musculus)
EHMT2 [nucleoplasm]
(Sus scrofa)
ehmt2 [nucleoplasm]
(Xenopus tropicalis)
Ehmt2 [nucleoplasm]
(Rattus norvegicus)
G9a [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_079532.5
,
NP_006700.3
,
NP_001305762.1
,
NP_001276342.1
Guide to Pharmacology - Targets
2652
OpenTargets
ENSG00000204371
IntEnz
2.1.1.367
HPA
ENSG00000204371-EHMT2
GeneCards
Q96KQ7
ZINC target
Q96KQ7
Ensembl
ENSG00000238134
,
ENSP00000416957
,
ENSP00000406110
,
ENSP00000372863
,
ENSP00000396119
,
ENST00000450229
,
ENST00000383372
,
ENST00000383373
,
ENSP00000372864
,
ENST00000421926
,
ENSG00000236759
,
ENSG00000232045
,
ENSP00000392305
,
ENSP00000400838
,
ENST00000450075
,
ENSG00000227333
,
ENST00000375537
,
ENSG00000204371
,
ENSG00000206376
,
ENSP00000411035
,
ENSP00000364680
,
ENSP00000364687
,
ENST00000429506
,
ENST00000420874
,
ENST00000420336
,
ENST00000375530
PRO
Q96KQ7
Pharos - Targets
Q96KQ7
PDB
3DM1
,
3K5K
,
5VSE
,
5JHN
,
5TTF
,
3RJW
,
7BTV
,
7DCF
,
5JIN
,
5T0M
,
7BUC
,
4NVQ
,
6MM1
,
2O8J
,
5V9I
,
5TUY
,
5VSC
,
5T0K
,
5JIY
,
5JJ0
HMDB Protein
HMDBP00419
Interactors (44)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60568 PLOD3
1
PLOD3 [endoplasmic reticulum membrane]
(R-HSA-1981135)
0.831
8
UniProt:Q9Y4X4 KLF12
0.739
5
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.737
7
UniProt:O95785 WIZ
0.725
4
UniProt:Q9H9B1 EHMT1
1
EHMT1 [nucleoplasm]
(R-HSA-1183226)
0.725
4
UniProt:O94776 MTA2
1
MTA2 [nucleoplasm]
(R-HSA-4657009)
0.677
7
UniProt:Q96JM2 ZN462
0.666
4
UniProt:P57682 KLF3
0.659
4
UniProt:P23771 GATA3
2
GATA3 [nucleoplasm]
(R-HSA-996768)
PolyUb-GATA3 [nucleoplasm]
(R-HSA-6783009)
0.612
20
UniProt:Q9BTC8 MTA3
1
MTA3 [nucleoplasm]
(R-HSA-4657013)
0.612
18
UniProt:Q92769 HDAC2
2
monoSUMO1-K462-HDAC2 [nucleoplasm]
(R-HSA-4615958)
HDAC2 [nucleoplasm]
(R-HSA-205135)
0.597
7
UniProt:O60315 ZEB2
0.577
6
UniProt:Q13330 MTA1
2
MTA1 [nucleoplasm]
(R-HSA-3465550)
polySUMO2,3-K509-MTA1 [nucleoplasm]
(R-HSA-3465537)
0.577
9
UniProt:Q99801-1 NKX3-1
0.558
3
UniProt:A0A0S2Z5X4 A0A0S2Z5X4
0.556
3
UniProt:Q9NWS9-2 ZNF446
0.556
3
UniProt:Q9BSU3 NAA11
0.556
3
UniProt:Q9P2R6 RERE
0.556
3
UniProt:Q6VMQ6-2 ATF7IP
0.556
3
UniProt:P38919 EIF4A3
2
EIF4A3 [cytosol]
(R-HSA-927868)
EIF4A3 [nucleoplasm]
(R-HSA-8849149)
0.556
3
UniProt:Q96JB3 HIC2
0.556
3
UniProt:Q96EG3 ZN837
0.556
3
UniProt:P20592 MX2
1
MX2 [cytosol]
(R-HSA-1015675)
0.556
3
UniProt:Q14119 VEZF1
0.556
3
UniProt:Q9UM22 EPDR1
0.556
3
UniProt:Q7Z3Z2 RD3
0.556
3
UniProt:Q96BV0 ZNF775
1
ZNF775 [nucleoplasm]
(R-HSA-3110230)
0.556
3
UniProt:Q99IB8-PRO_0000045599
0.547
2
UniProt:Q13185 CBX3
1
CBX3 [nucleoplasm]
(R-HSA-427386)
0.527
2
UniProt:Q9H582 ZN644
0.527
2
UniProt:P45973 CBX5
2
CBX5 [nucleoplasm]
(R-HSA-994093)
monoSUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
0.527
2
UniProt:Q8N108 MIER1
0.527
2
UniProt:P83916 CBX1
1
CBX1 [nucleoplasm]
(R-HSA-9653629)
0.527
2
UniProt:Q07120 GFI1
0.524
3
UniProt:Q92831 KAT2B
1
KAT2B [nucleoplasm]
(R-HSA-352430)
0.524
3
UniProt:Q6P1J9 CDC73
1
CDC73 [nucleoplasm]
(R-HSA-3322360)
0.524
3
UniProt:Q5JSZ5 PRC2B
0.508
2
UniProt:O60341-1 KDM1A
0.499
2
UniProt:O14646 CHD1
1
CHD1 [nucleoplasm]
(R-HSA-9012174)
0.499
2
UniProt:Q9NQX1 PRDM5
0.499
3
UniProt:P48431 SOX2
1
SOX2 [nucleoplasm]
(R-HSA-452271)
0.483
2
UniProt:Q9NHX6 Gug
1
GUG [cytosol]
(R-DME-350975)
0.463
2
UniProt:O95983 MBD3
1
MBD3 [nucleoplasm]
(R-HSA-4657010)
0.462
4
UniProt:O60341 KDM1A
1
KDM1A [nucleoplasm]
(R-HSA-996769)
0.462
5
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