Reactome | EHMT2 [nucleoplasm]

EHMT2 [nucleoplasm]

Stable Identifier

R-HSA-212151

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

G9a, Histone Methyltransferase G9a, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, KMT1C

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Locations in the PathwayBrowser for interactor UniProt:Q9H9B1 EHMT1

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External Reference Information

External Reference

UniProt:Q96KQ7 EHMT2

Gene Names

EHMT2, BAT8, C6orf30, G9A, KMT1C, NG36

Chain

initiator methionine:, chain:2-1210

Reference Genes

COSMIC (genes):EHMT2 EHMT2

dbSNP Gene:10919 EHMT2

ENSEMBL:ENSG00000204371 EHMT2

Participates

as a member of

EHMT1,2 [nucleoplasm] (Homo sapiens)

as an input of

Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene (Homo sapiens)

as a component of

Inferred To

Ghost homologue of EHMT2 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of EHMT2 [nucleoplasm] (Gallus gallus)

EHMT2 [nucleoplasm] (Bos taurus)

EHMT2 [nucleoplasm] (Canis familiaris)

EHMT2 [nucleoplasm] (Mus musculus)

EHMT2 [nucleoplasm] (Sus scrofa)

ehmt2 [nucleoplasm] (Xenopus tropicalis)

Ehmt2 [nucleoplasm] (Rattus norvegicus)

G9a [nucleoplasm] (Drosophila melanogaster)

Interactors (48)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60568 PLOD3	1	PLOD3 [endoplasmic reticulum membrane] (R-HSA-1981135)	0.831	8
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.794	9
UniProt:Q96JM2 ZN462			0.742	5
UniProt:Q9Y4X4 KLF12			0.739	5
UniProt:Q9H9B1 EHMT1	1	EHMT1 [nucleoplasm] (R-HSA-1183226)	0.725	4
UniProt:O95785 WIZ			0.725	4
UniProt:Q92769 HDAC2	2	HDAC2 [nucleoplasm] (R-HSA-205135) monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958)	0.69	8
UniProt:O94776 MTA2	1	MTA2 [nucleoplasm] (R-HSA-4657009)	0.677	7
UniProt:P57682 KLF3			0.659	4
UniProt:P83916 CBX1	1	CBX1 [nucleoplasm] (R-HSA-9653629)	0.643	3
UniProt:Q13185 CBX3	1	CBX3 [nucleoplasm] (R-HSA-427386)	0.643	3
UniProt:P23771 GATA3	2	GATA3 [nucleoplasm] (R-HSA-996768) PolyUb-GATA3 [nucleoplasm] (R-HSA-6783009)	0.612	20
UniProt:Q9BTC8 MTA3	1	MTA3 [nucleoplasm] (R-HSA-4657013)	0.612	18
UniProt:Q13330 MTA1	2	MTA1 [nucleoplasm] (R-HSA-3465550) polySUMO2,3-K509-MTA1 [nucleoplasm] (R-HSA-3465537)	0.577	9
UniProt:O60315 ZEB2	1	ZEB2 [nucleoplasm] (R-HSA-3108222)	0.577	6
UniProt:Q99801-1 NKX3-1			0.558	3
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.556	3
UniProt:Q96BV0 ZNF775	1	ZNF775 [nucleoplasm] (R-HSA-3110230)	0.556	3
UniProt:Q7Z3Z2 RD3			0.556	3
UniProt:Q9UM22 EPDR1			0.556	3
UniProt:Q14119 VEZF1			0.556	3
UniProt:P20592 MX2	1	MX2 [cytosol] (R-HSA-1015675)	0.556	3
UniProt:Q96EG3 ZN837			0.556	3
UniProt:Q96JB3 HIC2			0.556	3
UniProt:Q6VMQ6-2 ATF7IP			0.556	3
UniProt:Q9P2R6 RERE			0.556	3
UniProt:Q9BSU3 NAA11			0.556	3
UniProt:Q9NWS9-2 ZNF446			0.556	3
UniProt:A0A0S2Z5X4 A0A0S2Z5X4			0.556	3
UniProt:P84243 H3-3A	18	H3F3A [nucleoplasm] (R-HSA-212295) Me2K5-H3F3A [nucleoplasm] (R-HSA-1214206) Me3K-28-H3F3A [nucleoplasm] (R-HSA-212282) Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625747) p-T12,Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625758) p-T12, Me2K-10-H3F3A [nucleoplasm] (R-HSA-5625800) p-T12,MeK-H3F3A [nucleoplasm] (R-HSA-5625858) p-T12-H3F3A [nucleoplasm] (R-HSA-5625878) Me2K-10-H3F3A [nucleoplasm] (R-HSA-427324) Me3K5-H3F3A [nucleoplasm] (R-HSA-1214216) H3F3A [extracellular region] (R-HSA-977567) AcK10-H3F3A [nucleoplasm] (R-HSA-5250654) Me2K5,Me2aR2-H3F3A [nucleoplasm] (R-HSA-8936573) H3R17me2a [nucleoplasm] (R-HSA-9822613) MeK28-H3-3A [nucleoplasm] (R-HSA-9822942) Me1K5-H3-3A [nucleoplasm] (R-HSA-9864864) 2xAcK-H3F3A [nucleoplasm] (R-HSA-427504) MeK-H3F3A [nucleoplasm] (R-HSA-427369)	0.547	2
UniProt:Q99IB8-PRO_0000045599			0.547	2
UniProt:Q96GT9 XAGE2			0.547	3
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.527	2
UniProt:Q13363 CTBP1	3	CTBP1 [nucleoplasm] (R-HSA-212372) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200)	0.527	4
UniProt:Q9Y232 CDYL			0.527	2
UniProt:Q8N108 MIER1			0.527	2
UniProt:Q9H582 ZN644			0.527	2
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.524	3
UniProt:Q92831 KAT2B	1	KAT2B [nucleoplasm] (R-HSA-352430)	0.524	3
UniProt:Q07120 GFI1			0.524	3
UniProt:Q5JSZ5 PRC2B			0.508	2
UniProt:O60341-1 KDM1A			0.499	2
UniProt:Q9NQX1 PRDM5			0.499	3
UniProt:O14646 CHD1	1	CHD1 [nucleoplasm] (R-HSA-9012174)	0.499	2
UniProt:P48431 SOX2	1	SOX2 [nucleoplasm] (R-HSA-452271)	0.483	2
UniProt:Q9NHX6 Gug	1	GUG [cytosol] (R-DME-350975)	0.463	2
UniProt:O95983 MBD3	1	MBD3 [nucleoplasm] (R-HSA-4657010)	0.462	4
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.462	5

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