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EED [nucleoplasm]
Stable Identifier
R-HSA-212278
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Icon
Locations in the PathwayBrowser for interactor UniProt:Q8IXJ9 ASXL1
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
E2F1/2/3 stimulates EED transcription (Homo sapiens)
EED [nucleoplasm] (Homo sapiens)
Formation of PRC2-EZH2 complex (Homo sapiens)
EED [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75530 EED
Gene Names
EED
Chain
initiator methionine:, chain:2-441
Reference Genes
BioGPS Gene:8726 EED
COSMIC (genes):EED EED
CTD Gene:8726 EED
dbSNP Gene:8726 EED
ENSEMBL:ENSG00000074266 EED
ENSEMBL_homo_sapiens_GENE:ENSG00000074266.23 EED
HGNC:3188 EED
KEGG Gene (Homo sapiens):8726 EED
Monarch:8726 EED
NCBI Gene:8726 EED
OMIM:605984 EED
UCSC:O75530 EED
Reference Transcript
RefSeq:NM_003797.4 EED
RefSeq:NM_001308007.1 EED
Other Identifiers
11728378_a_at
11750166_a_at
11753489_a_at
16729712
209572_PM_s_at
209572_s_at
210656_PM_at
210656_at
31853_at
3343203
3343204
3343205
3343206
3343208
3343209
3343210
3343211
3343212
3343216
3343217
3343219
3343220
3343224
3343226
3343227
3343228
3343229
3343230
7942914
8726
A_14_P133848
A_14_P138443
A_23_P53217
GE81323
GO:0000122
GO:0001222
GO:0003682
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005829
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0008047
GO:0016740
GO:0021510
GO:0031491
GO:0035098
GO:0036211
GO:0042054
GO:0042802
GO:0043226
GO:0045892
GO:0048856
GO:0098772
GO:0140096
HMNXSV003036020
HMNXSV003039068
HMNXSV003042355
ILMN_1710150
ILMN_1796813
ILMN_2347917
PH_hs_0026886
TC11000870.hg
U90651_at
g3420789_3p_a_at
Participates
as an output of
E2F1/2/3 stimulates EED transcription (Homo sapiens)
as an input of
Formation of PRC2-EZH2 complex (Homo sapiens)
as a component of
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
Inferred To
EED [nucleoplasm]
(Bos taurus)
EED [nucleoplasm]
(Canis familiaris)
EED [nucleoplasm]
(Gallus gallus)
EED [nucleoplasm]
(Sus scrofa)
escl [nucleoplasm]
(Drosophila melanogaster)
Eed [nucleoplasm]
(Mus musculus)
Eed [nucleoplasm]
(Rattus norvegicus)
eed [nucleoplasm]
(Danio rerio)
eed [nucleoplasm]
(Xenopus tropicalis)
mes-6 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_003788.2
,
NP_001294936.1
Guide to Pharmacology - Targets
2487
OpenTargets
ENSG00000074266
HPA
ENSG00000074266-EED
GeneCards
O75530
ZINC target
O75530
Ensembl
ENST00000263360
,
ENSG00000074266
,
ENST00000351625
,
ENSP00000338186
,
ENST00000672825
,
ENSP00000500834
,
ENST00000327320
,
ENSP00000315587
,
ENSP00000263360
PRO
O75530
Pharos - Targets
O75530
PDB
5H17
,
6B3W
,
3IIW
,
3JZN
,
6V3Y
,
5H25
,
5IJ8
,
5U5T
,
6WKR
,
5IJ7
,
3IIY
,
6W7G
,
4W2R
,
5U5K
,
8FYH
,
3JPX
,
5WG6
,
5H14
,
5U8F
,
7QJG
,
5H15
,
6SFC
,
3JZG
,
3IJC
,
6U4Y
,
5U8A
,
5U6D
,
7P3G
,
6YVJ
,
5H19
,
6C24
,
6YVI
,
7P3C
,
5WP3
,
7KXT
,
6V3X
,
5GSA
,
5U62
,
7QK4
,
5K0M
,
7KTP
,
7TD5
,
7QJU
,
6W7F
,
3IJ0
,
5TTW
,
3JZH
,
5LS6
,
5U5H
,
5H24
,
3K27
,
5HYN
,
6SFB
,
5H13
,
7MSD
,
6LO2
,
7KSR
,
7MSB
,
7P3J
,
5U69
,
4X3E
,
7KSO
,
7SI5
,
3IJ1
,
6C23
,
3K26
,
5WUK
,
7SI4
Interactors (31)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15910 EZH2
1
EZH2 [nucleoplasm]
(R-HSA-212298)
0.922
17
UniProt:Q15022 SUZ12
2
SUZ12 [nucleoplasm]
(R-HSA-212217)
monoSUMO1-K75-SUZ12 [nucleoplasm]
(R-HSA-4615932)
0.909
12
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.788
8
UniProt:Q92800 EZH1
0.738
5
UniProt:O43189 PHF1
1
PHF1 [nucleoplasm]
(R-HSA-5084105)
0.725
6
UniProt:Q9UBC3 DNMT3B
2
SUMO1-K-DNMT3B [nucleoplasm]
(R-HSA-4655334)
DNMT3B [nucleoplasm]
(R-HSA-212316)
0.662
4
UniProt:Q6ZN18 AEBP2
1
AEBP2 [nucleoplasm]
(R-HSA-5082342)
0.648
5
UniProt:Q5T6S3 PHF19
1
PHF19 [nucleoplasm]
(R-HSA-5084115)
0.643
5
UniProt:Q9Y483 MTF2
1
MTF2 [nucleoplasm]
(R-HSA-5084119)
0.643
4
UniProt:Q92833 JARID2
1
JARID2 [nucleoplasm]
(R-HSA-2160949)
0.643
4
UniProt:Q16576 RBBP7
1
RBBP7 [nucleoplasm]
(R-HSA-212227)
0.643
6
UniProt:P26358 DNMT1
2
monoSUMO1-K-DNMT1 [nucleoplasm]
(R-HSA-4655353)
DNMT1 [nucleoplasm]
(R-HSA-212181)
0.623
3
IntAct:EBI-15887193 H3K27-1
0.618
3
UniProt:P49368 CCT3
1
CCT3 [cytosol]
(R-HSA-390463)
0.564
2
UniProt:Q16531 DDB1
1
DDB1 [nucleoplasm]
(R-HSA-53489)
0.564
4
IntAct:EBI-15643864 H3K9-1
0.558
5
IntAct:EBI-15887143 H3K79
0.558
2
IntAct:EBI-15887169 H1K26
0.558
2
IntAct:EBI-15697673 H4K20AC
0.558
2
UniProt:Q13620 CUL4B
2
CUL4B [nucleoplasm]
(R-HSA-975973)
G76-NEDD8-K859-CUL4B [nucleoplasm]
(R-HSA-8952522)
0.558
7
UniProt:Q96JN0 LCOR
0.527
4
UniProt:Q9JJY3
1
SMPD3 [plasma membrane]
(R-MMU-1606265)
0.527
5
UniProt:A6NHQ4 EPOP
0.527
3
UniProt:Q6ZN18-2 AEBP2
0.527
2
UniProt:P63244 RACK1
1
GNB2L1 [cytosol]
(R-HSA-5626956)
0.527
3
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.527
3
UniProt:O75530 EED
1
EED [nucleoplasm]
(R-HSA-212278)
0.525
2
UniProt:Q15156 Q15156
0.499
2
UniProt:Q8IXJ9 ASXL1
1
ASXL1 [nucleoplasm]
(R-HSA-5689645)
0.499
5
UniProt:Q92833-1 JARID2
0.499
4
UniProt:Q9Y6K1 DNMT3A
2
monoSUMO1-K-DNMT3A [nucleoplasm]
(R-HSA-4655415)
DNMT3A [nucleoplasm]
(R-HSA-212287)
0.499
2
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