Reactome | EED [nucleoplasm]

EED [nucleoplasm]

Stable Identifier

R-HSA-212278

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

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Locations in the PathwayBrowser for interactor UniProt:Q9UBC3 DNMT3B

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External Reference Information

External Reference

UniProt:O75530 EED

Gene Names

EED

Chain

initiator methionine:, chain:2-441

Reference Genes

COSMIC (genes):EED EED

dbSNP Gene:8726 EED

ENSEMBL:ENSG00000074266 EED

Participates

as an output of

E2F1/2/3 stimulates EED transcription (Homo sapiens)

as an input of

Formation of PRC2-EZH2 complex (Homo sapiens)

as a component of

PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)

Inferred To

EED [nucleoplasm] (Bos taurus)

EED [nucleoplasm] (Canis familiaris)

EED [nucleoplasm] (Gallus gallus)

EED [nucleoplasm] (Sus scrofa)

escl [nucleoplasm] (Drosophila melanogaster)

Eed [nucleoplasm] (Mus musculus)

Eed [nucleoplasm] (Rattus norvegicus)

eed [nucleoplasm] (Danio rerio)

eed [nucleoplasm] (Xenopus tropicalis)

mes-6 [nucleoplasm] (Caenorhabditis elegans)

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15910 EZH2	1	EZH2 [nucleoplasm] (R-HSA-212298)	0.922	17
UniProt:Q15022 SUZ12	2	SUZ12 [nucleoplasm] (R-HSA-212217) monoSUMO1-K75-SUZ12 [nucleoplasm] (R-HSA-4615932)	0.909	12
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.788	8
UniProt:Q92800 EZH1			0.738	5
UniProt:O43189 PHF1	1	PHF1 [nucleoplasm] (R-HSA-5084105)	0.725	6
UniProt:Q9UBC3 DNMT3B	2	DNMT3B [nucleoplasm] (R-HSA-212316) SUMO1-K-DNMT3B [nucleoplasm] (R-HSA-4655334)	0.662	4
UniProt:Q6ZN18 AEBP2	1	AEBP2 [nucleoplasm] (R-HSA-5082342)	0.648	5
UniProt:Q5T6S3 PHF19	1	PHF19 [nucleoplasm] (R-HSA-5084115)	0.643	5
UniProt:Q9Y483 MTF2	1	MTF2 [nucleoplasm] (R-HSA-5084119)	0.643	4
UniProt:Q92833 JARID2	1	JARID2 [nucleoplasm] (R-HSA-2160949)	0.643	4
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.643	6
UniProt:P26358 DNMT1	2	DNMT1 [nucleoplasm] (R-HSA-212181) monoSUMO1-K-DNMT1 [nucleoplasm] (R-HSA-4655353)	0.623	3
IntAct:EBI-15887193 H3K27-1			0.618	3
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.564	2
UniProt:Q16531 DDB1	1	DDB1 [nucleoplasm] (R-HSA-53489)	0.564	4
IntAct:EBI-15643864 H3K9-1			0.558	5
IntAct:EBI-15887143 H3K79			0.558	2
IntAct:EBI-15887169 H1K26			0.558	2
IntAct:EBI-15697673 H4K20AC			0.558	2
UniProt:Q13620 CUL4B	2	CUL4B [nucleoplasm] (R-HSA-975973) G76-NEDD8-K859-CUL4B [nucleoplasm] (R-HSA-8952522)	0.558	7
UniProt:Q96JN0 LCOR			0.527	4
UniProt:Q9JJY3	1	SMPD3 [plasma membrane] (R-MMU-1606265)	0.527	5
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.527	3
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.527	3
UniProt:A6NHQ4 EPOP			0.527	3
UniProt:Q6ZN18-2 AEBP2			0.527	2
UniProt:O75530 EED	1	EED [nucleoplasm] (R-HSA-212278)	0.525	2
UniProt:Q15156 Q15156			0.499	2
UniProt:Q8IXJ9 ASXL1	1	ASXL1 [nucleoplasm] (R-HSA-5689645)	0.499	5
UniProt:Q92833-1 JARID2			0.499	4
UniProt:Q9Y6K1 DNMT3A	2	DNMT3A [nucleoplasm] (R-HSA-212287) monoSUMO1-K-DNMT3A [nucleoplasm] (R-HSA-4655415)	0.499	2

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