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H3F3A [nucleoplasm]
Stable Identifier
R-HSA-212295
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Histone H3.3
Locations in the PathwayBrowser for interactor UniProt:Q13112 CAF1B
Expand all
Cell Cycle (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Inhibition of DNA recombination at telomere (Homo sapiens)
Histone H3.3 deposition at telomere (Homo sapiens)
H3F3A [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Maternal to zygotic transition (MZT) (Homo sapiens)
Replacement of protamines by nucleosomes in the male pronucleus (Homo sapiens)
METTL23 dimethylates histone H3.3 arginine-17 (arginine-18 in the preprotein) (Homo sapiens)
H3F3A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P84243 H3-3A
Gene Names
H3-3A, H3.3A, H3F3, H3F3A, PP781, H3-3B, H3.3B, H3F3B
Chain
initiator methionine:, chain:2-136
Reference Genes
BioGPS Gene:3020 H3-3A
BioGPS Gene:3021 H3-3A
CTD Gene:3020 H3-3A
CTD Gene:3021 H3-3A
dbSNP Gene:3020 H3-3A
dbSNP Gene:3021 H3-3A
ENSEMBL:ENSG00000132475 H3F3B
ENSEMBL:ENSG00000163041 H3F3A
ENSEMBL_homo_sapiens_GENE:ENSG00000132475.10 H3-3A
ENSEMBL_homo_sapiens_GENE:ENSG00000163041.13 H3-3A
HGNC:4764 H3-3A
HGNC:4765 H3-3A
KEGG Gene (Homo sapiens):3020 H3-3A
KEGG Gene (Homo sapiens):3021 H3-3A
Monarch:3020 H3-3A
Monarch:3021 H3-3A
NCBI Gene:3020 H3-3A
NCBI Gene:3021 H3-3A
OMIM:601058 H3-3A
OMIM:601128 H3-3A
UCSC:P84243 H3-3A
Reference Transcript
RefSeq:NM_002107.4 H3-3A
RefSeq:NM_005324.4 H3-3A
Other Identifiers
11715189_s_at
11739481_x_at
11754775_s_at
11756379_x_at
11757037_s_at
11757038_x_at
11758593_s_at
16650285
16650289
16650291
16650293
16650295
16848888
16887898
18670604
18670605
18670606
200080_PM_s_at
200080_s_at
208755_PM_x_at
208755_x_at
209069_PM_s_at
209069_s_at
211940_PM_x_at
211940_x_at
211997_PM_x_at
211997_x_at
211998_PM_at
211998_at
211999_PM_at
211999_at
213828_PM_x_at
213828_x_at
2383063
2383064
2383065
2383067
2383068
2383069
2383070
2383071
2383075
2383076
2383077
2383078
2383079
2383080
2516451
2516452
2516453
2516454
2516455
254_at
2739999
2740001
2740002
2786723
2786725
2786727
2786729
3020
3021
31510_s_at
3449959
3493224
3493226
3493227
3770943
3770945
3770946
3770947
3770948
3770949
3770950
3770951
3770952
3770954
3770955
3770957
3770958
3770959
3770961
3989613
3989617
3989619
3989621
4003653
73099_at
7894282
7895579
7896511
7910124
8018439
8046515
8102860
8169740
90048_at
A_14_P138929
A_23_P152516
A_23_P23141
A_24_P105298
A_24_P82419
A_24_P91035
A_32_P208424
A_33_P3410194
GE80224
GE80274
GO:0000781
GO:0000786
GO:0000978
GO:0000979
GO:0003677
GO:0005198
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005694
GO:0006325
GO:0006334
GO:0030307
GO:0030527
GO:0031492
GO:0032200
GO:0032991
GO:0043226
GO:0043229
GO:0046982
GO:0065003
GO:0070062
HMNXSV003016235
HMNXSV003029246
HMNXSV003033897
Hs.180877.1.A1_3p_s_at
Hs.180877.1.A3_3p_at
Hs.180877.1.A4_3p_at
Hs.181307.4.A1_3p_a_at
ILMN_1656082
ILMN_1695706
ILMN_1699015
ILMN_2106331
ILMN_2402930
ILMN_2402936
M11353_at
PH_hs_0027287
PH_hs_0032025
PH_hs_0040066
TC01001857.hg
TC01005067.hg
TC17001882.hg
X05855_s_at
Z48950_at
g12654576_3p_s_at
Participates
as a component of
Nucleosome (H3.3,H2AX) [nucleoplasm] (Homo sapiens)
Nucleosome (H3F3A) [nucleoplasm] (Homo sapiens)
as an input of
METTL23 dimethylates histone H3.3 arginine-17 (arginine-18 in the preprotein) (Homo sapiens)
Histone H3.3 deposition at telomere (Homo sapiens)
as a candidate of
Histone H3 [nucleoplasm] (Homo sapiens)
as a member of
Histone H3 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
MeK-H3F3A [nucleoplasm]
2xAcK-H3F3A [nucleoplasm]
Me1K5-H3-3A [nucleoplasm]
MeK28-H3-3A [nucleoplasm]
H3R17me2a [nucleoplasm]
Me2K5,Me2aR2-H3F3A [nucleoplasm]
AcK10-H3F3A [nucleoplasm]
H3F3A [extracellular region]
Me2K-10-H3F3A [nucleoplasm]
p-T12-H3F3A [nucleoplasm]
p-T12,MeK-H3F3A [nucleoplasm]
p-T12, Me2K-10-H3F3A [nucleoplasm]
p-T12,Me3K-10-H3F3A [nucleoplasm]
Me3K-10-H3F3A [nucleoplasm]
Me3K5-H3F3A [nucleoplasm]
Me3K-28-H3F3A [nucleoplasm]
Me2K5-H3F3A [nucleoplasm]
Inferred To
hht1 [nucleoplasm]
(Schizosaccharomyces pombe)
h3f3b.1 [nucleoplasm]
(Danio rerio)
Histone H3.3 [nucleoplasm]
(Mus musculus)
H3-3B [nucleoplasm]
(Bos taurus)
Homologues of H3F3A [nucleoplasm]
(Drosophila melanogaster)
Homologues of H3F3A [nucleoplasm]
(Schizosaccharomyces pombe)
HHT2 [nucleoplasm]
(Saccharomyces cerevisiae)
H3-X [nucleoplasm]
(Gallus gallus)
His3.3A [nucleoplasm]
(Drosophila melanogaster)
H3-3A [nucleoplasm]
(Sus scrofa)
His3.3B [nucleoplasm]
(Drosophila melanogaster)
hht3 [nucleoplasm]
(Schizosaccharomyces pombe)
his-71 [nucleoplasm]
(Caenorhabditis elegans)
H3-3b [nucleoplasm]
(Rattus norvegicus)
LOC612779 [nucleoplasm]
(Canis familiaris)
Cross References
RefSeq
NP_005315.1
,
NP_002098.1
OpenTargets
ENSG00000163041
HPA
ENSG00000163041-H3-3A
,
ENSG00000132475-H3-3B
GeneCards
P84243
Ensembl
ENSG00000163041
,
ENSP00000355778
,
ENSP00000465813
,
ENST00000589599
,
ENSP00000499385
,
ENST00000586607
,
ENST00000366816
,
ENSP00000355781
,
ENSP00000355780
,
ENST00000655399
,
ENSP00000466020
,
ENST00000254810
,
ENSP00000254810
,
ENST00000366813
,
ENST00000587560
,
ENST00000366815
,
ENSG00000132475
,
ENST00000666609
,
ENST00000661429
,
ENSP00000468714
,
ENSP00000499275
,
ENSP00000499800
PRO
P84243
Pharos - Targets
P84243
PDB
3WTP
,
3MUL
,
4H9R
,
5JA4
,
6PZV
,
3MUK
,
5KDM
,
6J4X
,
7WBV
,
6J4Y
,
6J50
,
2L43
,
4H9O
,
6QXZ
,
6A5L
,
6J4Z
,
4TMP
,
7WBW
,
3AV2
,
7XTI
,
3ASL
,
5BNV
,
7WBX
,
5BNX
,
7CJ0
,
6A5P
,
6A5O
,
3ASK
,
6U04
,
6RNY
,
7V1M
,
7XSX
,
4QQ4
,
5B32
,
8KB5
,
4GU0
,
4N4I
,
3JVK
,
7CIZ
,
6A5R
,
6J9J
,
4U7T
,
5JLB
,
4GNE
,
5DWQ
,
5DX0
,
4GUS
,
7OKP
,
6IR9
,
4GUR
,
5JJY
,
4L58
,
4H9Q
,
7XTD
,
4H9P
,
7CWH
,
6J51
,
3QLC
,
5X7X
,
6INQ
,
3QLA
,
4HGA
,
4GY5
,
4H9N
,
7V1L
,
7XSE
,
8JH2
,
4O62
,
7VCQ
,
8JH4
,
3QL9
,
8JH3
,
4W5A
,
6R0C
,
4GNG
,
7W5M
,
5B33
,
7XSZ
,
7XT7
,
4GNF
,
6HGT
,
6A5U
,
6A5T
,
7A08
,
6J4W
,
4H9S
Interactors (26)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62805 H4C1
17
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
HIST1H4A [extracellular region]
(R-HSA-977569)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
HIST1H4 [nucleoplasm]
(R-HSA-181902)
0.861
12
UniProt:Q9UER7 DAXX
13
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX [nucleoplasm]
(R-HSA-3222068)
0.85
8
UniProt:Q9UER7-1 DAXX
0.781
21
UniProt:Q9NVP2 ASF1B
0.723
5
UniProt:Q8R5C8 ZMY11
0.691
6
UniProt:P45973 CBX5
2
CBX5 [nucleoplasm]
(R-HSA-994093)
monoSUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
0.667
3
UniProt:P49736 MCM2
1
MCM2 [nucleoplasm]
(R-HSA-68557)
0.656
3
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.643
3
UniProt:P54198 HIRA
1
HIRA [nucleoplasm]
(R-HSA-2532790)
0.643
3
UniProt:Q13111 CAF1A
0.623
3
UniProt:Q9Y6K1 DNMT3A
2
monoSUMO1-K-DNMT3A [nucleoplasm]
(R-HSA-4655415)
DNMT3A [nucleoplasm]
(R-HSA-212287)
0.618
7
UniProt:Q9Y294 ASF1A
1
ASF1A [nucleoplasm]
(R-HSA-417169)
0.597
5
UniProt:Q15910 EZH2
1
EZH2 [nucleoplasm]
(R-HSA-212298)
0.597
7
UniProt:Q8IZL8 PELP1
1
PELP1 [nucleoplasm]
(R-HSA-3826531)
0.591
11
UniProt:P46100 ATRX
20
ATRX E288* [nucleoplasm]
(R-HSA-9670958)
ATRX K329Ifs*3 [nucleoplasm]
(R-HSA-9672232)
ATRX Q176* [nucleoplasm]
(R-HSA-9671592)
ATRX C268Qfs*18 [nucleoplasm]
(R-HSA-9672233)
ATRX Q177* [nucleoplasm]
(R-HSA-9671589)
ATRX K330Nfs*2 [nucleoplasm]
(R-HSA-9672231)
ATRX G161* [nucleoplasm]
(R-HSA-9671266)
ATRX Q176Hfs*13 [nucleoplasm]
(R-HSA-9671806)
ATRX R160Pfs*29 [nucleoplasm]
(R-HSA-9671801)
ATRX K319* [nucleoplasm]
(R-HSA-9671669)
ATRX W222* [nucleoplasm]
(R-HSA-9671670)
ATRX E63* [nucleoplasm]
(R-HSA-9670961)
ATRX S79* [nucleoplasm]
(R-HSA-9671244)
ATRX H166Mfs*4 [nucleoplasm]
(R-HSA-9672205)
ATRX Y266* [nucleoplasm]
(R-HSA-9671624)
ATRX L253* [nucleoplasm]
(R-HSA-9671688)
ATRX W263* [nucleoplasm]
(R-HSA-9671685)
ATRX Y187* [nucleoplasm]
(R-HSA-9671622)
ATRX Y204* [nucleoplasm]
(R-HSA-9671619)
ATRX Q292* [nucleoplasm]
(R-HSA-9671581)
0.564
2
UniProt:P49321-2 NASP
0.556
3
UniProt:Q96KQ7 EHMT2
1
EHMT2 [nucleoplasm]
(R-HSA-212151)
0.547
2
UniProt:Q5VWG9 TAF3
1
TAF3 [nucleoplasm]
(R-HSA-212446)
0.544
3
UniProt:Q13112 CAF1B
0.527
2
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
5
UniProt:Q8IV20 LACC1
0.527
2
UniProt:Q16576 RBBP7
1
RBBP7 [nucleoplasm]
(R-HSA-212227)
0.527
2
UniProt:Q9Y496 KIF3A
3
KIF3A [cilium]
(R-HSA-5610394)
KIF3A [cytosol]
(R-HSA-984767)
KIF3A [ciliary tip]
(R-HSA-5625377)
0.527
2
UniProt:Q8WVS4 DYNC2I1
2
WDR60 [ciliary tip]
(R-HSA-5625409)
WDR60 [cilium]
(R-HSA-5624903)
0.508
2
UniProt:Q96EX3 DYNC2I2
2
WDR34 [ciliary tip]
(R-HSA-5625407)
WDR34 [cilium]
(R-HSA-5624900)
0.508
2
UniProt:C4QZQ7 C4QZQ7
0.495
2
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