Reactome | EZH2 [nucleoplasm]

EZH2 [nucleoplasm]

Stable Identifier

R-HSA-212298

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

KMT6

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Locations in the PathwayBrowser for interactor UniProt:Q15022 SUZ12

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External Reference Information

External Reference

UniProt:Q15910 EZH2

Gene Names

EZH2, KMT6

Chain

chain:1-746

Reference Genes

BioGPS Gene:2146 EZH2

COSMIC (genes):EZH2 EZH2

CTD Gene:2146 EZH2

dbSNP Gene:2146 EZH2

ENSEMBL:ENSG00000106462 EZH2

HGNC:3527 EZH2

KEGG:hsa:2146 EZH2

Monarch:2146 EZH2

NCBI Gene:2146 EZH2

OMIM:601573 EZH2

UCSC:Q15910 EZH2

Reference Transcript

Participates

as an output of

E2F1/2/3 stimulates EZH2 transcription (Homo sapiens)

as an input of

Formation of PRC2-EZH2 complex (Homo sapiens)

as a component of

PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)

Inferred To

EZH2 [nucleoplasm] (Bos taurus)

EZH2 [nucleoplasm] (Canis familiaris)

EZH2 [nucleoplasm] (Gallus gallus)

EZH2 [nucleoplasm] (Sus scrofa)

ezh2 [nucleoplasm] (Danio rerio)

ezh2 [nucleoplasm] (Xenopus tropicalis)

Ezh2 [nucleoplasm] (Mus musculus)

Ezh2 [nucleoplasm] (Rattus norvegicus)

mes-2 [nucleoplasm] (Caenorhabditis elegans)

E(z) [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001190176.1, NP_694543.1, NP_001190177.1, XP_011514186.1, NP_001190178.1, NP_004447.2

Guide to Pharmacology - Targets

2654

OpenTargets

ENSG00000106462

ENSEMBL

ENSP00000223193, ENSP00000419711, ENSP00000419856, ENSP00000417062, ENST00000478654, ENST00000476773, ENST00000320356, ENST00000350995, ENST00000483967, ENST00000460911, ENSP00000419050, ENSG00000106462, ENSP00000320147

ZINC - Substances

EZH2_HUMAN

ZINC target

Q15910

PRO

Q15910

GlyGen

Q15910

PDB

8FYH, 5H19, 6LO2, 5IJ8, 5H17, 5IJ7, 7AT8, 5WG6, 7QK4, 5HYN, 5H25, 5GSA, 7QJG, 5LS6, 7QJU, 5H24, 4MI5, 5WUK, 8EQV, 5U5T, 6U4Y, 5U62, 8T9G, 6WKR, 9C8U, 4MI0, 8TB9, 6C24, 6C23, 8TAS, 5H15, 5H14, 6P5L

ZINC - Investigational

EZH2_HUMAN

IntEnz

2.1.1.356

GeneCards

EZH2

HPA

ENSG00000106462-EZH2

Pharos - Targets

Q15910

Orphanet

EZH2

ZINC - Predictions - Purchasable

EZH2_HUMAN

HMDB Protein

HMDBP09013

Interactors (34)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15022 SUZ12	2	SUZ12 [nucleoplasm] (R-HSA-212217) monoSUMO1-K75-SUZ12 [nucleoplasm] (R-HSA-4615932)	0.957	31
UniProt:O75530 EED	1	EED [nucleoplasm] (R-HSA-212278)	0.922	17
UniProt:O43189 PHF1	1	PHF1 [nucleoplasm] (R-HSA-5084105)	0.891	9
UniProt:Q9UBC3 DNMT3B	2	DNMT3B [nucleoplasm] (R-HSA-212316) SUMO1-K-DNMT3B [nucleoplasm] (R-HSA-4655334)	0.834	14
UniProt:Q6ZN18 AEBP2	1	AEBP2 [nucleoplasm] (R-HSA-5082342)	0.793	8
UniProt:Q92833 JARID2	1	JARID2 [nucleoplasm] (R-HSA-2160949)	0.788	7
UniProt:Q96JN0 LCOR			0.788	6
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.725	7
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.725	7
UniProt:A6NHQ4 EPOP			0.725	6
UniProt:Q9Y483 MTF2	1	MTF2 [nucleoplasm] (R-HSA-5084119)	0.725	5
UniProt:Q5T6S3 PHF19	1	PHF19 [nucleoplasm] (R-HSA-5084115)	0.725	6
UniProt:P26358 DNMT1	2	DNMT1 [nucleoplasm] (R-HSA-212181) monoSUMO1-K-DNMT1 [nucleoplasm] (R-HSA-4655353)	0.693	8
UniProt:Q9Y6K1 DNMT3A	2	DNMT3A [nucleoplasm] (R-HSA-212287) monoSUMO1-K-DNMT3A [nucleoplasm] (R-HSA-4655415)	0.677	6
UniProt:Q96MT8 CEP63	1	CEP63 [cytosol] (R-HSA-380267)	0.666	4
UniProt:Q9BZS1 FOXP3	1	FOXP3 [nucleoplasm] (R-HSA-8865539)	0.602	9
UniProt:P84243 H3-3A	18	H3F3A [nucleoplasm] (R-HSA-212295) Me2K5-H3F3A [nucleoplasm] (R-HSA-1214206) Me3K-28-H3F3A [nucleoplasm] (R-HSA-212282) Me3K5-H3F3A [nucleoplasm] (R-HSA-1214216) Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625747) p-T12,Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625758) p-T12, Me2K-10-H3F3A [nucleoplasm] (R-HSA-5625800) p-T12,MeK-H3F3A [nucleoplasm] (R-HSA-5625858) p-T12-H3F3A [nucleoplasm] (R-HSA-5625878) Me2K-10-H3F3A [nucleoplasm] (R-HSA-427324) H3F3A [extracellular region] (R-HSA-977567) AcK10-H3F3A [nucleoplasm] (R-HSA-5250654) Me2K5,Me2aR2-H3F3A [nucleoplasm] (R-HSA-8936573) H3R17me2a [nucleoplasm] (R-HSA-9822613) MeK28-H3-3A [nucleoplasm] (R-HSA-9822942) Me1K5-H3-3A [nucleoplasm] (R-HSA-9864864) 2xAcK-H3F3A [nucleoplasm] (R-HSA-427504) MeK-H3F3A [nucleoplasm] (R-HSA-427369)	0.597	7
UniProt:Q13620 CUL4B	2	CUL4B [nucleoplasm] (R-HSA-975973) G76-NEDD8-K859-CUL4B [nucleoplasm] (R-HSA-8952522)	0.597	15
UniProt:Q15156 Q15156			0.576	8
UniProt:P10275 AR	4	AR [nucleoplasm] (R-HSA-446174) AR [cytosol] (R-HSA-5618082) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984)	0.564	2
UniProt:Q92833-1 JARID2			0.558	7
UniProt:Q8IXJ9 ASXL1	1	ASXL1 [nucleoplasm] (R-HSA-5689645)	0.558	6
UniProt:P62877 RBX1	2	RBX1 [cytosol] (R-HSA-180582) RBX1 [nucleoplasm] (R-HSA-1234142)	0.527	4
UniProt:Q92800 EZH1			0.527	2
UniProt:P35226 BMI1	3	BMI1 [nucleoplasm] (R-HSA-389121) p-S-BMI1 [nucleoplasm] (R-HSA-3229116) monoSUMO1-K88-BMI1 [nucleoplasm] (R-HSA-4551729)	0.527	7
UniProt:P46100 ATRX	20	ATRX E288* [nucleoplasm] (R-HSA-9670958) ATRX K329Ifs3 [nucleoplasm] (R-HSA-9672232) ATRX Q176 [nucleoplasm] (R-HSA-9671592) ATRX C268Qfs18 [nucleoplasm] (R-HSA-9672233) ATRX Q177 [nucleoplasm] (R-HSA-9671589) ATRX K330Nfs2 [nucleoplasm] (R-HSA-9672231) ATRX G161 [nucleoplasm] (R-HSA-9671266) ATRX Q176Hfs13 [nucleoplasm] (R-HSA-9671806) ATRX R160Pfs29 [nucleoplasm] (R-HSA-9671801) ATRX K319* [nucleoplasm] (R-HSA-9671669) ATRX W222* [nucleoplasm] (R-HSA-9671670) ATRX E63* [nucleoplasm] (R-HSA-9670961) ATRX S79* [nucleoplasm] (R-HSA-9671244) ATRX H166Mfs4 [nucleoplasm] (R-HSA-9672205) ATRX Y266 [nucleoplasm] (R-HSA-9671624) ATRX L253* [nucleoplasm] (R-HSA-9671688) ATRX W263* [nucleoplasm] (R-HSA-9671685) ATRX Y187* [nucleoplasm] (R-HSA-9671622) ATRX Y204* [nucleoplasm] (R-HSA-9671619) ATRX Q292* [nucleoplasm] (R-HSA-9671581)	0.524	2
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.508	2
UniProt:Q9CWR8 Dnmt3l	1	Dnmt3l [nucleoplasm] (R-MMU-5334127)	0.499	2
UniProt:P40763 STAT3	12	p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-STAT3 [cytosol] (R-HSA-8982823) p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811)	0.499	5
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.462	2
UniProt:Q16531 DDB1	1	DDB1 [nucleoplasm] (R-HSA-53489)	0.462	10
IntAct:EBI-5276484 ACTB			0.462	2
IntAct:EBI-1265559 MYC			0.462	2
UniProt:A4PIW0 A4PIW0			0.462	5