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Go!
EZH2 [nucleoplasm]
Stable Identifier
R-HSA-212298
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
KMT6
Icon
Locations in the PathwayBrowser for interactor UniProt:Q8IXJ9 ASXL1
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
E2F1/2/3 stimulates EZH2 transcription (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
Formation of PRC2-EZH2 complex (Homo sapiens)
EZH2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15910 EZH2
Gene Names
EZH2, KMT6
Chain
chain:1-746
Reference Genes
BioGPS Gene:2146 EZH2
COSMIC (genes):EZH2 EZH2
CTD Gene:2146 EZH2
dbSNP Gene:2146 EZH2
ENSEMBL:ENSG00000106462 EZH2
ENSEMBL_homo_sapiens_GENE:ENSG00000106462.12 EZH2
HGNC:3527 EZH2
KEGG Gene (Homo sapiens):2146 EZH2
Monarch:2146 EZH2
NCBI Gene:2146 EZH2
OMIM:601573 EZH2
UCSC:Q15910 EZH2
Reference Transcript
RefSeq:XM_011515884.2 EZH2
RefSeq:NM_001203247.1 EZH2
RefSeq:NM_004456.4 EZH2
RefSeq:NM_001203248.1 EZH2
RefSeq:NM_152998.2 EZH2
RefSeq:NM_001203249.1 EZH2
Other Identifiers
11717657_a_at
11748690_a_at
17064105
203358_PM_s_at
203358_s_at
2146
3078349
3078350
3078352
3078353
3078356
3078358
3078360
3078362
3078364
3078369
3078371
3078374
3078377
3078382
3078383
3078384
3078385
3078386
3078391
3078392
3078393
3078399
3078400
3078401
37305_at
3919611
3930675
8143663
A_23_P259641
A_33_P3252196
GE59277
GO:0000082
GO:0000122
GO:0000278
GO:0000781
GO:0000785
GO:0000976
GO:0000978
GO:0000979
GO:0001222
GO:0001932
GO:0002376
GO:0003012
GO:0003677
GO:0003682
GO:0003714
GO:0003723
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005677
GO:0005694
GO:0005721
GO:0006306
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006357
GO:0006954
GO:0008168
GO:0008284
GO:0009913
GO:0010468
GO:0010629
GO:0010718
GO:0014013
GO:0014834
GO:0014898
GO:0016279
GO:0016740
GO:0021695
GO:0021766
GO:0023052
GO:0030097
GO:0030154
GO:0030183
GO:0030216
GO:0031490
GO:0031507
GO:0031509
GO:0032200
GO:0032259
GO:0032355
GO:0034244
GO:0035098
GO:0035984
GO:0036211
GO:0036333
GO:0042054
GO:0042127
GO:0042752
GO:0043021
GO:0043226
GO:0043406
GO:0043547
GO:0043565
GO:0045120
GO:0045202
GO:0045605
GO:0045617
GO:0045814
GO:0045892
GO:0046976
GO:0048387
GO:0048511
GO:0048856
GO:0048863
GO:0050767
GO:0051154
GO:0051932
GO:0070301
GO:0070314
GO:0070734
GO:0070878
GO:0071168
GO:0071902
GO:0090183
GO:0097421
GO:0106222
GO:0140096
GO:0140110
GO:0140718
GO:0140938
GO:0140951
GO:1900006
GO:1900016
GO:1902808
GO:1904772
GO:1990841
GO:2000134
GO:2000737
HMNXSV003004831
ILMN_1652913
ILMN_1708105
ILMN_2364529
PH_hs_0025941
TC07001993.hg
U61145_at
g4758323_3p_a_at
Participates
as an output of
E2F1/2/3 stimulates EZH2 transcription (Homo sapiens)
as an input of
Formation of PRC2-EZH2 complex (Homo sapiens)
as a component of
PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)
Inferred To
EZH2 [nucleoplasm]
(Bos taurus)
EZH2 [nucleoplasm]
(Canis familiaris)
EZH2 [nucleoplasm]
(Gallus gallus)
EZH2 [nucleoplasm]
(Sus scrofa)
ezh2 [nucleoplasm]
(Danio rerio)
ezh2 [nucleoplasm]
(Xenopus tropicalis)
Ezh2 [nucleoplasm]
(Mus musculus)
Ezh2 [nucleoplasm]
(Rattus norvegicus)
mes-2 [nucleoplasm]
(Caenorhabditis elegans)
E(z) [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_694543.1
,
NP_001190176.1
,
NP_001190178.1
,
NP_004447.2
,
NP_001190177.1
,
XP_011514186.1
Guide to Pharmacology - Targets
2654
OpenTargets
ENSG00000106462
ZINC - Substances
EZH2_HUMAN
ZINC target
Q15910
PRO
Q15910
PDB
8FYH
,
5H19
,
5U5T
,
5U62
,
5H17
,
5LS6
,
5HYN
,
4MI5
,
6LO2
,
7QK4
,
5H15
,
7AT8
,
5WUK
,
5H14
,
6WKR
,
7QJU
,
6P5L
,
6U4Y
,
6C23
,
5H25
,
6C24
,
4MI0
,
5WG6
,
5IJ7
,
7QJG
,
5H24
,
5IJ8
,
5GSA
ZINC - Investigational
EZH2_HUMAN
HPA
ENSG00000106462-EZH2
GeneCards
Q15910
Ensembl
ENST00000478654
,
ENSP00000419050
,
ENSP00000417062
,
ENST00000460911
,
ENST00000483967
,
ENST00000320356
,
ENST00000476773
,
ENSP00000320147
,
ENSP00000223193
,
ENSG00000106462
,
ENSP00000419856
,
ENSP00000419711
,
ENST00000350995
Pharos - Targets
Q15910
Orphanet
20793
ZINC - Predictions - Purchasable
EZH2_HUMAN
HMDB Protein
HMDBP09013
Interactors (34)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15022 SUZ12
2
SUZ12 [nucleoplasm]
(R-HSA-212217)
monoSUMO1-K75-SUZ12 [nucleoplasm]
(R-HSA-4615932)
0.957
31
UniProt:O75530 EED
1
EED [nucleoplasm]
(R-HSA-212278)
0.922
17
UniProt:O43189 PHF1
1
PHF1 [nucleoplasm]
(R-HSA-5084105)
0.891
9
UniProt:Q9UBC3 DNMT3B
2
SUMO1-K-DNMT3B [nucleoplasm]
(R-HSA-4655334)
DNMT3B [nucleoplasm]
(R-HSA-212316)
0.834
14
UniProt:Q6ZN18 AEBP2
1
AEBP2 [nucleoplasm]
(R-HSA-5082342)
0.793
8
UniProt:Q96JN0 LCOR
0.788
6
UniProt:Q92833 JARID2
1
JARID2 [nucleoplasm]
(R-HSA-2160949)
0.788
7
UniProt:Q5T6S3 PHF19
1
PHF19 [nucleoplasm]
(R-HSA-5084115)
0.725
6
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.725
7
UniProt:Q9Y483 MTF2
1
MTF2 [nucleoplasm]
(R-HSA-5084119)
0.725
5
UniProt:A6NHQ4 EPOP
0.725
6
UniProt:Q16576 RBBP7
1
RBBP7 [nucleoplasm]
(R-HSA-212227)
0.725
7
UniProt:P26358 DNMT1
2
monoSUMO1-K-DNMT1 [nucleoplasm]
(R-HSA-4655353)
DNMT1 [nucleoplasm]
(R-HSA-212181)
0.693
8
UniProt:Q9Y6K1 DNMT3A
2
monoSUMO1-K-DNMT3A [nucleoplasm]
(R-HSA-4655415)
DNMT3A [nucleoplasm]
(R-HSA-212287)
0.677
6
UniProt:Q96MT8 CEP63
1
CEP63 [cytosol]
(R-HSA-380267)
0.666
4
UniProt:Q9BZS1 FOXP3
1
FOXP3 [nucleoplasm]
(R-HSA-8865539)
0.602
9
UniProt:Q13620 CUL4B
2
CUL4B [nucleoplasm]
(R-HSA-975973)
G76-NEDD8-K859-CUL4B [nucleoplasm]
(R-HSA-8952522)
0.597
15
UniProt:P84243 H3-3A
18
MeK-H3F3A [nucleoplasm]
(R-HSA-427369)
2xAcK-H3F3A [nucleoplasm]
(R-HSA-427504)
Me1K5-H3-3A [nucleoplasm]
(R-HSA-9864864)
MeK28-H3-3A [nucleoplasm]
(R-HSA-9822942)
H3R17me2a [nucleoplasm]
(R-HSA-9822613)
Me2K5,Me2aR2-H3F3A [nucleoplasm]
(R-HSA-8936573)
AcK10-H3F3A [nucleoplasm]
(R-HSA-5250654)
H3F3A [extracellular region]
(R-HSA-977567)
Me2K-10-H3F3A [nucleoplasm]
(R-HSA-427324)
p-T12-H3F3A [nucleoplasm]
(R-HSA-5625878)
p-T12,MeK-H3F3A [nucleoplasm]
(R-HSA-5625858)
p-T12, Me2K-10-H3F3A [nucleoplasm]
(R-HSA-5625800)
p-T12,Me3K-10-H3F3A [nucleoplasm]
(R-HSA-5625758)
Me3K-10-H3F3A [nucleoplasm]
(R-HSA-5625747)
Me3K5-H3F3A [nucleoplasm]
(R-HSA-1214216)
Me3K-28-H3F3A [nucleoplasm]
(R-HSA-212282)
H3F3A [nucleoplasm]
(R-HSA-212295)
Me2K5-H3F3A [nucleoplasm]
(R-HSA-1214206)
0.597
7
UniProt:Q15156 Q15156
0.576
8
UniProt:P10275 AR
4
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
monoSUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
AR [nucleoplasm]
(R-HSA-446174)
AR [cytosol]
(R-HSA-5618082)
0.564
2
UniProt:Q8IXJ9 ASXL1
1
ASXL1 [nucleoplasm]
(R-HSA-5689645)
0.558
6
UniProt:Q92833-1 JARID2
0.558
7
UniProt:P35226 BMI1
3
BMI1 [nucleoplasm]
(R-HSA-389121)
p-S-BMI1 [nucleoplasm]
(R-HSA-3229116)
monoSUMO1-K88-BMI1 [nucleoplasm]
(R-HSA-4551729)
0.527
7
UniProt:Q92800 EZH1
0.527
2
UniProt:P62877 RBX1
2
RBX1 [nucleoplasm]
(R-HSA-1234142)
RBX1 [cytosol]
(R-HSA-180582)
0.527
4
UniProt:P46100 ATRX
20
ATRX E288* [nucleoplasm]
(R-HSA-9670958)
ATRX K329Ifs*3 [nucleoplasm]
(R-HSA-9672232)
ATRX Q176* [nucleoplasm]
(R-HSA-9671592)
ATRX C268Qfs*18 [nucleoplasm]
(R-HSA-9672233)
ATRX Q177* [nucleoplasm]
(R-HSA-9671589)
ATRX K330Nfs*2 [nucleoplasm]
(R-HSA-9672231)
ATRX G161* [nucleoplasm]
(R-HSA-9671266)
ATRX Q176Hfs*13 [nucleoplasm]
(R-HSA-9671806)
ATRX R160Pfs*29 [nucleoplasm]
(R-HSA-9671801)
ATRX K319* [nucleoplasm]
(R-HSA-9671669)
ATRX W222* [nucleoplasm]
(R-HSA-9671670)
ATRX E63* [nucleoplasm]
(R-HSA-9670961)
ATRX S79* [nucleoplasm]
(R-HSA-9671244)
ATRX H166Mfs*4 [nucleoplasm]
(R-HSA-9672205)
ATRX Y266* [nucleoplasm]
(R-HSA-9671624)
ATRX L253* [nucleoplasm]
(R-HSA-9671688)
ATRX W263* [nucleoplasm]
(R-HSA-9671685)
ATRX Y187* [nucleoplasm]
(R-HSA-9671622)
ATRX Y204* [nucleoplasm]
(R-HSA-9671619)
ATRX Q292* [nucleoplasm]
(R-HSA-9671581)
0.524
2
UniProt:O43463 SUV39H1
1
SUV39H1 [nucleoplasm]
(R-HSA-427517)
0.508
2
UniProt:P40763 STAT3
12
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
p-STAT3 [cytosol]
(R-HSA-8982823)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.499
5
UniProt:Q9CWR8 Dnmt3l
1
Dnmt3l [nucleoplasm]
(R-MMU-5334127)
0.499
2
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.462
2
UniProt:A4PIW0 A4PIW0
0.462
5
IntAct:EBI-1265559 MYC
0.462
2
IntAct:EBI-5276484 ACTB
0.462
2
UniProt:Q16531 DDB1
1
DDB1 [nucleoplasm]
(R-HSA-53489)
0.462
10
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