Reactome | EZH2 [nucleoplasm]

EZH2 [nucleoplasm]

Stable Identifier

R-HSA-212298

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

KMT6

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Locations in the PathwayBrowser for interactor UniProt:Q9UBC3 DNMT3B

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External Reference Information

External Reference

UniProt:Q15910 EZH2

Gene Names

EZH2, KMT6

Chain

chain:1-746

Reference Genes

COSMIC (genes):EZH2 EZH2

dbSNP Gene:2146 EZH2

ENSEMBL:ENSG00000106462 EZH2

Participates

as an output of

E2F1/2/3 stimulates EZH2 transcription (Homo sapiens)

as an input of

Formation of PRC2-EZH2 complex (Homo sapiens)

as a component of

PRC2 (EZH2) Core [nucleoplasm] (Homo sapiens)

Inferred To

EZH2 [nucleoplasm] (Bos taurus)

EZH2 [nucleoplasm] (Canis familiaris)

EZH2 [nucleoplasm] (Gallus gallus)

EZH2 [nucleoplasm] (Sus scrofa)

ezh2 [nucleoplasm] (Danio rerio)

ezh2 [nucleoplasm] (Xenopus tropicalis)

Ezh2 [nucleoplasm] (Mus musculus)

Ezh2 [nucleoplasm] (Rattus norvegicus)

mes-2 [nucleoplasm] (Caenorhabditis elegans)

E(z) [nucleoplasm] (Drosophila melanogaster)

Interactors (34)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15022 SUZ12	2	SUZ12 [nucleoplasm] (R-HSA-212217) monoSUMO1-K75-SUZ12 [nucleoplasm] (R-HSA-4615932)	0.957	31
UniProt:O75530 EED	1	EED [nucleoplasm] (R-HSA-212278)	0.922	17
UniProt:O43189 PHF1	1	PHF1 [nucleoplasm] (R-HSA-5084105)	0.891	9
UniProt:Q9UBC3 DNMT3B	2	DNMT3B [nucleoplasm] (R-HSA-212316) SUMO1-K-DNMT3B [nucleoplasm] (R-HSA-4655334)	0.834	14
UniProt:Q6ZN18 AEBP2	1	AEBP2 [nucleoplasm] (R-HSA-5082342)	0.793	8
UniProt:Q96JN0 LCOR			0.788	6
UniProt:Q92833 JARID2	1	JARID2 [nucleoplasm] (R-HSA-2160949)	0.788	7
UniProt:Q5T6S3 PHF19	1	PHF19 [nucleoplasm] (R-HSA-5084115)	0.725	6
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.725	7
UniProt:Q9Y483 MTF2	1	MTF2 [nucleoplasm] (R-HSA-5084119)	0.725	5
UniProt:A6NHQ4 EPOP			0.725	6
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.725	7
UniProt:P26358 DNMT1	2	DNMT1 [nucleoplasm] (R-HSA-212181) monoSUMO1-K-DNMT1 [nucleoplasm] (R-HSA-4655353)	0.693	8
UniProt:Q9Y6K1 DNMT3A	2	DNMT3A [nucleoplasm] (R-HSA-212287) monoSUMO1-K-DNMT3A [nucleoplasm] (R-HSA-4655415)	0.677	6
UniProt:Q96MT8 CEP63	1	CEP63 [cytosol] (R-HSA-380267)	0.666	4
UniProt:Q9BZS1 FOXP3	1	FOXP3 [nucleoplasm] (R-HSA-8865539)	0.602	9
UniProt:P84243 H3-3A	18	H3F3A [nucleoplasm] (R-HSA-212295) Me2K5-H3F3A [nucleoplasm] (R-HSA-1214206) Me3K-28-H3F3A [nucleoplasm] (R-HSA-212282) Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625747) p-T12,Me3K-10-H3F3A [nucleoplasm] (R-HSA-5625758) p-T12, Me2K-10-H3F3A [nucleoplasm] (R-HSA-5625800) p-T12,MeK-H3F3A [nucleoplasm] (R-HSA-5625858) p-T12-H3F3A [nucleoplasm] (R-HSA-5625878) Me2K-10-H3F3A [nucleoplasm] (R-HSA-427324) Me3K5-H3F3A [nucleoplasm] (R-HSA-1214216) H3F3A [extracellular region] (R-HSA-977567) AcK10-H3F3A [nucleoplasm] (R-HSA-5250654) Me2K5,Me2aR2-H3F3A [nucleoplasm] (R-HSA-8936573) H3R17me2a [nucleoplasm] (R-HSA-9822613) MeK28-H3-3A [nucleoplasm] (R-HSA-9822942) Me1K5-H3-3A [nucleoplasm] (R-HSA-9864864) 2xAcK-H3F3A [nucleoplasm] (R-HSA-427504) MeK-H3F3A [nucleoplasm] (R-HSA-427369)	0.597	7
UniProt:Q13620 CUL4B	2	CUL4B [nucleoplasm] (R-HSA-975973) G76-NEDD8-K859-CUL4B [nucleoplasm] (R-HSA-8952522)	0.597	15
UniProt:Q15156 Q15156			0.576	8
UniProt:P10275 AR	4	AR [cytosol] (R-HSA-5618082) AR [nucleoplasm] (R-HSA-446174) monoSUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984)	0.564	2
UniProt:Q8IXJ9 ASXL1	1	ASXL1 [nucleoplasm] (R-HSA-5689645)	0.558	6
UniProt:Q92833-1 JARID2			0.558	7
UniProt:P35226 BMI1	3	BMI1 [nucleoplasm] (R-HSA-389121) p-S-BMI1 [nucleoplasm] (R-HSA-3229116) monoSUMO1-K88-BMI1 [nucleoplasm] (R-HSA-4551729)	0.527	7
UniProt:Q92800 EZH1			0.527	2
UniProt:P62877 RBX1	2	RBX1 [cytosol] (R-HSA-180582) RBX1 [nucleoplasm] (R-HSA-1234142)	0.527	4
UniProt:P46100 ATRX	20	ATRX E288* [nucleoplasm] (R-HSA-9670958) ATRX K329Ifs3 [nucleoplasm] (R-HSA-9672232) ATRX Q176 [nucleoplasm] (R-HSA-9671592) ATRX C268Qfs18 [nucleoplasm] (R-HSA-9672233) ATRX Q177 [nucleoplasm] (R-HSA-9671589) ATRX K330Nfs2 [nucleoplasm] (R-HSA-9672231) ATRX G161 [nucleoplasm] (R-HSA-9671266) ATRX Q176Hfs13 [nucleoplasm] (R-HSA-9671806) ATRX R160Pfs29 [nucleoplasm] (R-HSA-9671801) ATRX K319* [nucleoplasm] (R-HSA-9671669) ATRX W222* [nucleoplasm] (R-HSA-9671670) ATRX E63* [nucleoplasm] (R-HSA-9670961) ATRX S79* [nucleoplasm] (R-HSA-9671244) ATRX H166Mfs4 [nucleoplasm] (R-HSA-9672205) ATRX Y266 [nucleoplasm] (R-HSA-9671624) ATRX L253* [nucleoplasm] (R-HSA-9671688) ATRX W263* [nucleoplasm] (R-HSA-9671685) ATRX Y187* [nucleoplasm] (R-HSA-9671622) ATRX Y204* [nucleoplasm] (R-HSA-9671619) ATRX Q292* [nucleoplasm] (R-HSA-9671581)	0.524	2
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.508	2
UniProt:P40763 STAT3	12	p-Y705-STAT3 [nucleoplasm] (R-HSA-1112554) p-Y705-STAT3 [cytosol] (R-HSA-914048) STAT3 [cytosol] (R-HSA-539044) p-Y705-STAT3 [cytosol] (R-HSA-8983130) p-Y705,S727-STAT3 [cytosol] (R-HSA-539048) p-S727-STAT3 [cytosol] (R-HSA-198705) p-Y705-STAT3 [nucleoplasm] (R-HSA-9027589) p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701429) AcK685- p-Y705,S727-STAT3 [nucleoplasm] (R-HSA-9701435) p-STAT3 [cytosol] (R-HSA-8982823) p-STAT3 [nucleoplasm] (R-HSA-8983188) Unfolded STAT3 [cytosol] (R-HSA-6813811)	0.499	5
UniProt:Q9CWR8 Dnmt3l	1	Dnmt3l [nucleoplasm] (R-MMU-5334127)	0.499	2
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.462	2
UniProt:A4PIW0 A4PIW0			0.462	5
IntAct:EBI-1265559 MYC			0.462	2
IntAct:EBI-5276484 ACTB			0.462	2
UniProt:Q16531 DDB1	1	DDB1 [nucleoplasm] (R-HSA-53489)	0.462	10