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TLE1 [nucleoplasm]
Stable Identifier
R-HSA-212327
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
NOTCH1 Intracellular Domain Regulates Transcription (Homo sapiens)
HES1 binds TLE (Homo sapiens)
HES1:TLE [nucleoplasm] (Homo sapiens)
TLE [nucleoplasm] (Homo sapiens)
TLE1 [nucleoplasm] (Homo sapiens)
TLE [nucleoplasm] (Homo sapiens)
TLE1 [nucleoplasm] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Degradation of beta-catenin by the destruction complex (Homo sapiens)
Repression of WNT target genes (Homo sapiens)
TLE forms non-functional complexes with AES (Homo sapiens)
TLE [nucleoplasm] (Homo sapiens)
TLE1 [nucleoplasm] (Homo sapiens)
TLE:AES [nucleoplasm] (Homo sapiens)
TLE [nucleoplasm] (Homo sapiens)
TLE1 [nucleoplasm] (Homo sapiens)
TLE oligomerizes (Homo sapiens)
TLE [nucleoplasm] (Homo sapiens)
TLE1 [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE1 tetramer [nucleoplasm] (Homo sapiens)
TLE1 [nucleoplasm] (Homo sapiens)
TLE recruits HDAC1 to WNT promoters (Homo sapiens)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE1 tetramer [nucleoplasm] (Homo sapiens)
TLE1 [nucleoplasm] (Homo sapiens)
'canonical' WNT target genes:TCF/LEF:TLE tetramer:HDAC1 [nucleoplasm] (Homo sapiens)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE1 tetramer [nucleoplasm] (Homo sapiens)
TLE1 [nucleoplasm] (Homo sapiens)
TLE tetramers bind TCF/LEF at WNT promoters (Homo sapiens)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE1 tetramer [nucleoplasm] (Homo sapiens)
TLE1 [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE1 tetramer [nucleoplasm] (Homo sapiens)
TLE1 [nucleoplasm] (Homo sapiens)
Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes (Homo sapiens)
'canonical' WNT target genes:TCF/LEF:TLE tetramer:HDAC1 [nucleoplasm] (Homo sapiens)
'canonical' WNT target gene:TCF/LEF:TLE tetramer [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE1 tetramer [nucleoplasm] (Homo sapiens)
TLE1 [nucleoplasm] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Deactivation of the beta-catenin transactivating complex (Homo sapiens)
XIAP binds TLE (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE1 tetramer [nucleoplasm] (Homo sapiens)
TLE1 [nucleoplasm] (Homo sapiens)
TLE:XIAP [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE1 tetramer [nucleoplasm] (Homo sapiens)
TLE1 [nucleoplasm] (Homo sapiens)
XIAP monoubiquinates TLE (Homo sapiens)
TLE:XIAP [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE1 tetramer [nucleoplasm] (Homo sapiens)
TLE1 [nucleoplasm] (Homo sapiens)
beta-catenin is replaced by repression complexes at the promoter (Homo sapiens)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Homo sapiens)
TLE:HDAC1 [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE1 tetramer [nucleoplasm] (Homo sapiens)
TLE1 [nucleoplasm] (Homo sapiens)
TLE1:HDAC1 [nucleoplasm] (Homo sapiens)
TLE1 tetramer [nucleoplasm] (Homo sapiens)
TLE1 [nucleoplasm] (Homo sapiens)
Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
Beta-catenin displaces TLE:HDAC1 from TCF/LEF (Homo sapiens)
TCF/LEF:TLE:HDAC1 [nucleoplasm] (Homo sapiens)
TLE:HDAC1 [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE1 tetramer [nucleoplasm] (Homo sapiens)
TLE1 [nucleoplasm] (Homo sapiens)
TLE tetramer [nucleoplasm] (Homo sapiens)
TLE1 tetramer [nucleoplasm] (Homo sapiens)
TLE1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q04724 TLE1
Gene Names
TLE1
Chain
chain:1-770
Reference Genes
BioGPS Gene:7088 TLE1
COSMIC (genes):TLE1 TLE1
CTD Gene:7088 TLE1
dbSNP Gene:7088 TLE1
ENSEMBL:ENSG00000196781 TLE1
ENSEMBL_homo_sapiens_GENE:ENSG00000196781.16 TLE1
HGNC:11837 TLE1
KEGG Gene (Homo sapiens):7088 TLE1
Monarch:7088 TLE1
NCBI Gene:7088 TLE1
OMIM:600189 TLE1
UCSC:Q04724 TLE1
Reference Transcript
RefSeq:NM_005077.4 TLE1
RefSeq:NM_001303103.1 TLE1
RefSeq:NM_001303104.1 TLE1
Other Identifiers
11740414_a_at
17095150
203220_PM_s_at
203220_s_at
203221_PM_at
203221_at
203222_PM_s_at
203222_s_at
3176267
3211580
3211581
3211583
3211585
3211586
3211588
3211590
3211591
3211592
3211597
3211599
3211604
3211605
3211606
3211609
3211613
3211619
3211637
3211639
3211653
3211654
3211659
3211662
3211663
3211664
3979574
41489_at
7088
8161919
A_23_P135239
A_33_P3217719
GE58188
GO:0003714
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005829
GO:0006351
GO:0006355
GO:0007165
GO:0009887
GO:0010628
GO:0012501
GO:0016055
GO:0023052
GO:0030178
GO:0042802
GO:0043124
GO:0043226
GO:0045892
GO:0048856
GO:0090090
GO:0140110
GO:0140297
GO:1990907
GO:2000811
HMNXSV003033673
HMNXSV003043281
Hs.28935.0.A1_3p_a_at
Hs.28935.0.A3_3p_at
ILMN_1751572
M99435_at
PH_hs_0024679
TC09001258.hg
g4827027_3p_a_at
Participates
as a member of
TLE [nucleoplasm] (Homo sapiens)
TLE [nucleoplasm] (Homo sapiens)
as a component of
TLE1 tetramer [nucleoplasm] (Homo sapiens)
Other forms of this molecule
Ub-TLE1 [nucleoplasm]
Inferred To
gro [nucleoplasm]
(Drosophila melanogaster)
tle1 [nucleoplasm]
(Xenopus tropicalis)
TLE1 [nucleoplasm]
(Bos taurus)
TLE1 [nucleoplasm]
(Canis familiaris)
TLE1 [nucleoplasm]
(Gallus gallus)
TLE1 [nucleoplasm]
(Sus scrofa)
unc-37 [nucleoplasm]
(Caenorhabditis elegans)
Tle1 [nucleoplasm]
(Mus musculus)
Tle1 [nucleoplasm]
(Rattus norvegicus)
Cross References
RefSeq
NP_005068.2
,
NP_001290032.1
,
NP_001290033.1
OpenTargets
ENSG00000196781
GeneCards
Q04724
HPA
ENSG00000196781-TLE1
Ensembl
ENSP00000365682
,
ENSG00000196781
,
ENST00000376499
PRO
Q04724
Pharos - Targets
Q04724
PDB
4OM3
,
5MWJ
,
2CE8
,
4OM2
,
2CE9
,
1GXR
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13761 RUNX3
7
RUNX3 [nucleoplasm]
(R-HSA-8865393)
RUNX3 [cytosol]
(R-HSA-8937797)
Ac-K94,K171-RUNX3 [nucleoplasm]
(R-HSA-8951965)
PolyUb-K94,K148-RUNX3 [cytosol]
(R-HSA-8952400)
PolyUb-K94,K148-RUNX3 [nucleoplasm]
(R-HSA-8952387)
p-Y-RUNX3 [cytosol]
(R-HSA-8937805)
PolyUb-RUNX3 [nucleoplasm]
(R-HSA-8952417)
0.593
3
UniProt:Q08117 TLE5
1
AES [nucleoplasm]
(R-HSA-4648963)
0.564
3
UniProt:P04183 TK1
1
TK1 [cytosol]
(R-HSA-73500)
0.553
2
UniProt:O95231 VENTX
1
VENTX [nucleoplasm]
(R-HSA-8853887)
0.547
2
UniProt:Q9H2X6 HIPK2
3
p-HIPK2 [nucleoplasm]
(R-HSA-6799375)
HIPK2 [nucleoplasm]
(R-HSA-3215222)
monoSUMO1-K32-HIPK2 [nucleoplasm]
(R-HSA-4090405)
0.544
2
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.508
4
UniProt:Q9HC29 NOD2
1
NOD2 [cytosol]
(R-HSA-168411)
0.508
2
UniProt:P15336 ATF2
2
ATF2 [nucleoplasm]
(R-HSA-450336)
p-T69,T71-ATF2 [nucleoplasm]
(R-HSA-450243)
0.462
10
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