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CTBP1 [nucleoplasm]
Stable Identifier
R-HSA-212372
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
CtBP
Icon
Locations in the PathwayBrowser for interactor UniProt:Q9H9B1 EHMT1
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
PRC1 SUMOylates CTBP1 with SUMO1 (Homo sapiens)
CTBP1 [nucleoplasm] (Homo sapiens)
PRC1 SUMOylates CTBP1 with SUMO2,3 (Homo sapiens)
CTBP1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Deactivation of the beta-catenin transactivating complex (Homo sapiens)
APC promotes disassembly of beta-catenin transactivation complex (Homo sapiens)
CTBP1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13363 CTBP1
Gene Names
CTBP1, CTBP
Chain
chain:1-440
Reference Genes
BioGPS Gene:1487 CTBP1
COSMIC (genes):CTBP1 CTBP1
CTD Gene:1487 CTBP1
dbSNP Gene:1487 CTBP1
ENSEMBL:ENSG00000159692 CTBP1
ENSEMBL_homo_sapiens_GENE:ENSG00000159692.18 CTBP1
HGNC:2494 CTBP1
KEGG Gene (Homo sapiens):1487 CTBP1
Monarch:1487 CTBP1
NCBI Gene:1487 CTBP1
OMIM:602618 CTBP1
UCSC:Q13363 CTBP1
Reference Transcript
RefSeq:NM_001328.2 CTBP1
RefSeq:XM_017007766.1 CTBP1
RefSeq:XM_017007764.1 CTBP1
RefSeq:XM_017007767.1 CTBP1
RefSeq:NM_001012614.1 CTBP1
RefSeq:XM_017007765.1 CTBP1
Other Identifiers
11719960_a_at
11719961_s_at
11738637_a_at
11745679_a_at
1487
203392_PM_s_at
203392_s_at
212863_PM_x_at
212863_x_at
213980_PM_s_at
213980_s_at
2757035
2757037
2757038
2757039
2757040
2757041
2757042
2757043
2757046
2757048
2757051
2757058
2757059
2757071
2757072
2757073
2757080
2757103
2757104
2757106
2757112
2757113
41308_at
41309_g_at
43382_s_at
55310_at
8098880
A_23_P41286
A_23_P41292
A_24_P208992
A_33_P3357979
GE61587
GO:0000122
GO:0001221
GO:0001222
GO:0003682
GO:0003713
GO:0003714
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0006351
GO:0006355
GO:0006357
GO:0006468
GO:0008285
GO:0016192
GO:0016491
GO:0016616
GO:0017053
GO:0019079
GO:0019904
GO:0030154
GO:0036211
GO:0042802
GO:0043226
GO:0045892
GO:0045893
GO:0048488
GO:0050872
GO:0051287
GO:0051726
GO:0061629
GO:0097091
GO:0098831
GO:0098978
GO:0098982
GO:0140110
GO:0140297
HMNXSV003052557
Hs.239737.2.A1_3p_a_at
Hs.239737.2.A1_3p_x_at
ILMN_1719158
ILMN_2278235
ILMN_2379734
TC04000963.hg
U37408_at
g4557496_3p_a_at
Participates
as an input of
PRC1 SUMOylates CTBP1 with SUMO1 (Homo sapiens)
PRC1 SUMOylates CTBP1 with SUMO2,3 (Homo sapiens)
APC promotes disassembly of beta-catenin transactivation complex (Homo sapiens)
as a member of
CTBPs [nucleoplasm] (Homo sapiens)
as a component of
APC:CTBP:CTNNB1:BTRC [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm] (Homo sapiens)
Other forms of this molecule
monoSUMO1-K428-CTBP1 [nucleoplasm]
polySUMO2,3-K428-CTBP1 [nucleoplasm]
Inferred To
wu:fa96d06 [nucleoplasm]
(Danio rerio)
CTBP1 [nucleoplasm]
(Bos taurus)
CTBP1 [nucleoplasm]
(Caenorhabditis elegans)
CTBP1 [nucleoplasm]
(Canis familiaris)
CTBP1 [nucleoplasm]
(Drosophila melanogaster)
CTBP1 [nucleoplasm]
(Gallus gallus)
CTBP1 [nucleoplasm]
(Mus musculus)
CTBP1 [nucleoplasm]
(Rattus norvegicus)
CTBP1 [nucleoplasm]
(Sus scrofa)
ctbp1 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001319.1
,
XP_016863256.1
,
XP_016863255.1
,
XP_016863254.1
,
NP_001012632.1
,
XP_016863253.1
OpenTargets
ENSG00000159692
HPA
ENSG00000159692-CTBP1
GeneCards
Q13363
Ensembl
ENSP00000515195
,
ENSP00000515211
,
ENSG00000159692
,
ENST00000382952
,
ENST00000290921
,
ENSP00000290921
,
ENST00000703163
,
ENSP00000372411
,
ENST00000703138
PRO
Q13363
Pharos - Targets
Q13363
Orphanet
29802
HMDB Protein
HMDBP02216
PDB
8ARI
,
6V89
,
6V8A
,
1MX3
,
4U6Q
,
6CDF
,
7KWM
,
6CDR
,
4LCE
,
4U6S
Interactors (60)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P56545 CTBP2
1
CTBP2 [nucleoplasm]
(R-HSA-5333990)
0.918
17
UniProt:Q92618 ZN516
0.884
16
UniProt:Q96JN0 LCOR
0.878
11
UniProt:P37275 ZEB1
1
ZEB1 [nucleoplasm]
(R-HSA-6789836)
0.859
12
UniProt:O75362 ZNF217
1
ZNF217 [nucleoplasm]
(R-HSA-9011738)
0.848
11
UniProt:Q8N3X6 LCORL
0.837
7
UniProt:O60315 ZEB2
1
ZEB2 [nucleoplasm]
(R-HSA-3108222)
0.802
9
UniProt:P25054 APC
20
APC R213* [cytosol]
(R-HSA-9666924)
APC C1410* [cytosol]
(R-HSA-9666925)
APC K1310* [cytosol]
(R-HSA-9666926)
APC R499* [cytosol]
(R-HSA-9666927)
APC R1450* [cytosol]
(R-HSA-5251499)
APC G1357* [cytosol]
(R-HSA-9666940)
APC L1488* [cytosol]
(R-HSA-9666941)
APC S1400* [cytosol]
(R-HSA-9666942)
APC S1346* [cytosol]
(R-HSA-9666943)
APC R405* [cytosol]
(R-HSA-9666936)
APC S1281* [cytosol]
(R-HSA-9666937)
APC E1573* [cytosol]
(R-HSA-9666938)
APC R805* [cytosol]
(R-HSA-9666939)
APC R1386* [cytosol]
(R-HSA-9666932)
APC S1327* [cytosol]
(R-HSA-9666933)
APC E1209* [cytosol]
(R-HSA-9666934)
APC Q1469* [cytosol]
(R-HSA-9666935)
APC R564* [cytosol]
(R-HSA-9666928)
APC E1536* [cytosol]
(R-HSA-9666929)
APC G1288* [cytosol]
(R-HSA-9666930)
0.802
6
UniProt:O60341 KDM1A
1
KDM1A [nucleoplasm]
(R-HSA-996769)
0.788
7
UniProt:Q9UKL0 RCOR1
1
RCOR1 [nucleoplasm]
(R-HSA-996766)
0.788
11
UniProt:O95785 WIZ
0.774
8
UniProt:Q13363 CTBP1
3
monoSUMO1-K428-CTBP1 [nucleoplasm]
(R-HSA-3108200)
polySUMO2,3-K428-CTBP1 [nucleoplasm]
(R-HSA-3108226)
CTBP1 [nucleoplasm]
(R-HSA-212372)
0.748
8
UniProt:Q99592 ZBT18
0.744
7
UniProt:Q9H6R7 WDCP
2
WDCP(1-680)-p-7Y-ALK(1061-1620) fusion [cytosol]
(R-HSA-9700468)
WDCP(1-680)-ALK(1061-1620) fusion [cytosol]
(R-HSA-9700460)
0.725
7
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.725
8
UniProt:Q96EK4 THA11
0.716
4
UniProt:Q9UHF7 TRPS1
0.706
4
UniProt:O00257 CBX4
2
monoSUMO1-K494-CBX4 [nucleoplasm]
(R-HSA-4551626)
CBX4 [nucleoplasm]
(R-HSA-389118)
0.695
5
UniProt:Q99708 RBBP8
4
p-S327,T847-RBBP8 [nucleoplasm]
(R-HSA-5684083)
RBBP8 [nucleoplasm]
(R-HSA-912399)
Ac-K-RBBP8 [nucleoplasm]
(R-HSA-5685955)
p-S327,T847,T859-RBBP8 [nucleoplasm]
(R-HSA-5684138)
0.691
4
UniProt:P48552 NRIP1
2
monoSUMO1-K756,K1154-NRIP1 [nucleoplasm]
(R-HSA-4086057)
NRIP1 [nucleoplasm]
(R-HSA-4086031)
0.683
3
UniProt:Q9H9B1 EHMT1
1
EHMT1 [nucleoplasm]
(R-HSA-1183226)
0.643
5
UniProt:Q96MY1 NOL4L
0.643
6
UniProt:Q96PK6 RBM14
1
RBM14 [nucleoplasm]
(R-HSA-8938345)
0.643
4
UniProt:Q92769 HDAC2
2
monoSUMO1-K462-HDAC2 [nucleoplasm]
(R-HSA-4615958)
HDAC2 [nucleoplasm]
(R-HSA-205135)
0.643
9
UniProt:P06400 RB1
20
RB1 R661W [nucleoplasm]
(R-HSA-9659801)
RB1 C706F [nucleoplasm]
(R-HSA-9659812)
RB1 N480del [nucleoplasm]
(R-HSA-9659792)
RB1 C706Y [nucleoplasm]
(R-HSA-9659821)
RB1 R661Q [nucleoplasm]
(R-HSA-9659807)
RB1 I703_E737del [nucleoplasm]
(R-HSA-9661065)
RB1 R830_G887del [cytosol]
(R-HSA-9661059)
RB1 K791* [cytosol]
(R-HSA-9662284)
RB1 Q176* [cytosol]
(R-HSA-9661774)
RB1 S114* [cytosol]
(R-HSA-9661775)
RB1 K765* [cytosol]
(R-HSA-9662281)
RB1 W99* [cytosol]
(R-HSA-9661769)
RB1 S149* [cytosol]
(R-HSA-9661770)
RB1 E166* [cytosol]
(R-HSA-9661767)
RB1 G100* [cytosol]
(R-HSA-9661763)
RB1 E125* [cytosol]
(R-HSA-9661784)
RB1 Q121* [cytosol]
(R-HSA-9661780)
RB1 E184* [cytosol]
(R-HSA-9661781)
RB1 E137* [cytosol]
(R-HSA-9661782)
RB1 K745* [cytosol]
(R-HSA-9662288)
0.643
3
UniProt:Q8N895 ZN366
0.633
5
UniProt:O94818 NOL4
0.615
3
UniProt:Q13029 PRDM2
0.615
3
UniProt:Q5H9F3 BCORL
0.615
3
UniProt:Q9HAZ2 PRDM16
2
PRDM16 [nucleoplasm]
(R-HSA-3222269)
PRDM16 [cytosol]
(R-HSA-5634812)
0.615
3
UniProt:Q03112 MECOM
2
MECOM [cytosol]
(R-HSA-5634790)
MECOM [nucleoplasm]
(R-HSA-8943897)
0.615
3
UniProt:Q9Y5P3 RAI2
0.594
3
UniProt:P03255 E1A
0.593
3
UniProt:Q14526 HIC1
2
monoSUMO1-K333-HIC1 [nucleoplasm]
(R-HSA-4090368)
HIC1 [nucleoplasm]
(R-HSA-4090364)
0.573
2
UniProt:Q6W2J9 BCOR
0.569
3
UniProt:O15409 FOXP2
0.553
2
UniProt:A7XYQ1 SOBP
0.547
2
UniProt:Q96JN0-2 LCOR
0.547
2
UniProt:Q69140 EBNA6
0.544
2
UniProt:P67870 CSNK2B
5
CSNK2B [secretory granule lumen]
(R-HSA-6801319)
CSNK2B [extracellular region]
(R-HSA-6806508)
CSNK2B [ficolin-1-rich granule lumen]
(R-HSA-6801290)
CSNK2B [nucleoplasm]
(R-HSA-6805067)
CSNK2B [cytosol]
(R-HSA-201693)
0.527
2
UniProt:P28749 RBL1
2
RBL1 [nucleoplasm]
(R-HSA-389104)
p-T369,S640,S964,S975-RBL1 [nucleoplasm]
(R-HSA-1226085)
0.527
2
UniProt:Q8IZ40 RCOR2
0.527
2
UniProt:Q5JU69 TOR2A
0.527
2
UniProt:Q96JB3 HIC2
0.527
2
UniProt:Q96KQ7 EHMT2
1
EHMT2 [nucleoplasm]
(R-HSA-212151)
0.527
4
UniProt:Q9P2K3 RCOR3
0.527
3
UniProt:P08833 IGFBP1
3
p-IGFBP1 [endoplasmic reticulum lumen]
(R-HSA-8957029)
IGFBP1 [endoplasmic reticulum lumen]
(R-HSA-8956699)
IGFBP1 [extracellular region]
(R-HSA-381513)
0.527
2
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.527
2
UniProt:Q13627 DYRK1A
1
DYRK1A [nucleoplasm]
(R-HSA-1362267)
0.527
2
UniProt:O43474 KLF4
1
KLF4 [nucleoplasm]
(R-HSA-434463)
0.524
4
UniProt:P57682 KLF3
0.519
2
UniProt:Q9Y4X4 KLF12
0.519
2
UniProt:Q9BXL5 HEMGN
0.508
2
UniProt:Q9NYB0 TERF2IP
1
TERF2IP [nucleoplasm]
(R-HSA-174873)
0.508
2
UniProt:Q15583 TGIF1
1
TGIF1 [nucleoplasm]
(R-HSA-2186594)
0.508
2
UniProt:A2APF7 A2APF7
0.499
2
UniProt:Q92766 RREB1
0.483
2
UniProt:Q8NDX5 PHC3
1
PHC3 [nucleoplasm]
(R-HSA-389116)
0.483
2
UniProt:Q6ZRI6 CO039
0.483
2
UniProt:Q96AV8 E2F7
1
E2F7 [nucleoplasm]
(R-HSA-6798305)
0.483
2
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