Reactome | MED10 [nucleoplasm]

MED10 [nucleoplasm]

Stable Identifier

R-HSA-212410

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser for interactor UniProt:Q9NX70 MED29

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External Reference Information

External Reference

UniProt:Q9BTT4 MED10

Gene Names

MED10, L6, TRG17, TRG20

Chain

chain:1-135

Reference Genes

BioGPS Gene:84246 MED10

COSMIC (genes):MED10 MED10

CTD Gene:84246 MED10

dbSNP Gene:84246 MED10

ENSEMBL:ENSG00000133398 MED10

HGNC:28760 MED10

KEGG:hsa:84246 MED10

Monarch:84246 MED10

NCBI Gene:84246 MED10

OMIM:612382 MED10

UCSC:Q9BTT4 MED10

Reference Transcript

RefSeq:NM_032286.2 MED10

Other Identifiers

11742951_at

16994161

223247_PM_at

223247_at

2847265

2847266

2847267

2847268

2847272

2847273

2847275

2847276

2847279

2847280

78479_at

8110886

84246

A_23_P124022

A_23_P124024

GE62343

GO:0000151

GO:0003712

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0006355

GO:0006357

GO:0016567

GO:0016592

GO:0016740

GO:0032968

GO:0035019

GO:0045944

GO:0051123

GO:0060261

GO:0061630

GO:0065003

GO:0070847

GO:0140096

HMNXSV003043037

ILMN_1707631

PH_hs_0032208

TC05001137.hg

g13097161_3p_at

Participates

as a component of

as an input of

Inferred To

mdt-10 [nucleoplasm] (Caenorhabditis elegans)

Med10 [nucleoplasm] (Mus musculus)

Med10 [nucleoplasm] (Rattus norvegicus)

med10 [nucleoplasm] (Danio rerio)

med10 [nucleoplasm] (Schizosaccharomyces pombe)

med10 [nucleoplasm] (Xenopus tropicalis)

MED10 [nucleoplasm] (Bos taurus)

MED10 [nucleoplasm] (Canis familiaris)

MED10 [nucleoplasm] (Drosophila melanogaster)

MED10 [nucleoplasm] (Gallus gallus)

MED10 [nucleoplasm] (Sus scrofa)

NUT2 [nucleoplasm] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_115662.2

OpenTargets

ENSG00000133398

ENSEMBL

ENST00000708561, ENSG00000133398, ENST00000255764, ENSG00000291745, ENSP00000517281, ENSP00000255764

GeneCards

MED10

HPA

ENSG00000133398-MED10

PRO

Q9BTT4

Pharos - Targets

Q9BTT4

PDB

7ENJ, 8GXS, 8GXQ, 7ENC, 7ENA, 7NVR, 7EMF, 7LBM, 8T9D, 8TRH, 8TQW

Interactors (45)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NVC6 MED17	1	MED17 [nucleoplasm] (R-HSA-212401)	0.927	14
UniProt:Q9BUE0 MED18	1	MED18 [nucleoplasm] (R-HSA-556826)	0.92	14
UniProt:O43513 MED7	1	MED7 [nucleoplasm] (R-HSA-212430)	0.916	10
UniProt:Q96G25 MED8	1	MED8 [nucleoplasm] (R-HSA-556784)	0.911	13
UniProt:A0JLT2 MED19	1	MED19 [nucleoplasm] (R-HSA-556819)	0.911	12
UniProt:Q13503 MED21	1	MED21 [nucleoplasm] (R-HSA-212456)	0.911	12
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.909	12
UniProt:Q9H944 MED20	1	MED20 [nucleoplasm] (R-HSA-212428)	0.901	11
UniProt:O95402 MED26	1	MED26 [nucleoplasm] (R-HSA-556783)	0.901	12
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.901	9
UniProt:Q15528 MED22	1	MED22 [nucleoplasm] (R-HSA-556779)	0.901	9
UniProt:Q9P086 MED11	1	MED11 [nucleoplasm] (R-HSA-556808)	0.901	9
UniProt:O75448 MED24	1	MED24 [nucleoplasm] (R-HSA-212331)	0.867	8
UniProt:Q96HR3 MED30	1	MED30 [nucleoplasm] (R-HSA-212398)	0.867	8
UniProt:O75586 MED6	1	MED6 [nucleoplasm] (R-HSA-212359)	0.867	10
UniProt:Q9Y3C7 MED31	1	MED31 [nucleoplasm] (R-HSA-212429)	0.867	10
UniProt:Q9NX70 MED29	1	MED29 [nucleoplasm] (R-HSA-556821)	0.867	12
UniProt:Q93074 MED12	1	MED12 [nucleoplasm] (R-HSA-212343)	0.837	8
UniProt:Q6P2C8 MED27	1	MED27 [nucleoplasm] (R-HSA-556761)	0.825	8
UniProt:O60244 MED14	1	MED14 [nucleoplasm] (R-HSA-212441)	0.825	8
UniProt:Q9NWA0 MED9	1	MED9 [nucleoplasm] (R-HSA-556804)	0.825	9
UniProt:Q9Y2X0 MED16	1	MED16 [nucleoplasm] (R-HSA-556802)	0.825	7
UniProt:Q9ULK4 MED23	1	MED23 [nucleoplasm] (R-HSA-556823)	0.82	7
UniProt:P49336 CDK8	1	CDK8 [nucleoplasm] (R-HSA-212440)	0.802	10
UniProt:Q71SY5 MED25	1	MED25 [nucleoplasm] (R-HSA-212414)	0.793	7
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.788	6
UniProt:Q9H204 MED28	1	MED28 [nucleoplasm] (R-HSA-6804546)	0.775	7
UniProt:Q9UHV7 MED13	1	MED13 [nucleoplasm] (R-HSA-212391)	0.725	5
UniProt:Q71F56 MED13L	1	MED13L [nucleoplasm] (R-HSA-556797)	0.725	5
UniProt:Q96RN5 MED15	1	MED15 [nucleoplasm] (R-HSA-556827)	0.71	5
UniProt:Q9BWU1 CDK19	1	CDK19 [nucleoplasm] (R-HSA-556782)	0.708	6
UniProt:P19388 POLR2E	2	POLR2E [cytosol] (R-HSA-1964438) POLR2E [nucleoplasm] (R-HSA-83713)	0.643	3
UniProt:O15514 POLR2D	1	POLR2D [nucleoplasm] (R-HSA-63508)	0.643	3
UniProt:Q9NYB9-2 ABI2			0.556	3
UniProt:Q99819 ARHGDIG	1	ARHGDIG [cytosol] (R-HSA-195087)	0.556	3
UniProt:Q9H8W5-2 TRIM45			0.556	3
IntAct:EBI-22318856 CCSB ORF ID			0.556	3
UniProt:P04066 FUCA1	3	FUCA1 [extracellular region] (R-HSA-6806209) FUCA1 [azurophil granule lumen] (R-HSA-6798773) FUCA1 [lysosomal lumen] (R-HSA-5693804)	0.556	3
UniProt:P24928 POLR2A	8	p-S5(CTD)-POLR2A [nucleoplasm] (R-HSA-77100) POLR2A [nucleoplasm] (R-HSA-63502) p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-113420) p-3S-POLR2A [nucleoplasm] (R-HSA-6797701) Ub,p-S2,S5(CTD)-POLR2A [nucleoplasm] (R-HSA-6781855) p-S5,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6810226) p-S2,S7(CTD)-POLR2A [nucleoplasm] (R-HSA-6814543) p-S2(CTD)-POLR2A [nucleoplasm] (R-HSA-9970465)	0.527	3
UniProt:P30876 POLR2B	1	POLR2B [nucleoplasm] (R-HSA-63504)	0.527	2
UniProt:P0CG47 UBB	20	UBB(77-152) [endocytic vesicle membrane] (R-HSA-939253) UBB(1-76) [endocytic vesicle membrane] (R-HSA-939231) UBB(153-228) [endocytic vesicle membrane] (R-HSA-939171) Ub-33-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783023) Ub-109-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783008) Ub-185-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783046) Ub-158-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783162) Ub-6-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783014) Ub-82-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783015) Ub-163-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783025) Ub-87-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6782998) Ub-11-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783109) Ub-124-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783131) Ub-200-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783100) Ub-48-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783165) Ub-181-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783160) Ub-29-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783070) Ub-105-UBB(77-152) [mitochondrial outer membrane] (R-HSA-6783103) Ub-27-UBB(1-76) [mitochondrial outer membrane] (R-HSA-6783038) Ub-179-UBB(153-228) [mitochondrial outer membrane] (R-HSA-6783114)	0.527	2
UniProt:O15392 BIRC5	3	BIRC5 [cytosol] (R-HSA-50851) BIRC5 [nucleoplasm] (R-HSA-4655344) ub-BIRC5 [cytosol] (R-HSA-8955933)	0.527	2
UniProt:Q9BTT4 MED10	1	MED10 [nucleoplasm] (R-HSA-212410)	0.527	2
UniProt:P19387 POLR2C	1	POLR2C [nucleoplasm] (R-HSA-63506)	0.527	2
UniProt:O95988 TCL1B			0.527	2

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