Reactome | CCNC [nucleoplasm]

CCNC [nucleoplasm]

Stable Identifier

R-HSA-212418

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CycC

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P24863 CCNC

Gene Names

CCNC

Chain

chain:1-283

Reference Genes

BioGPS Gene:892 CCNC

COSMIC (genes):CCNC CCNC

CTD Gene:892 CCNC

dbSNP Gene:892 CCNC

ENSEMBL:ENSG00000112237 CCNC

HGNC:1581 CCNC

KEGG:hsa:892 CCNC

Monarch:892 CCNC

NCBI Gene:892 CCNC

OMIM:123838 CCNC

UCSC:P24863 CCNC

Reference Transcript

Other Identifiers

11726983_s_at

11726984_a_at

11726985_x_at

1569126_PM_at

1569126_at

17021978

1923_at

201955_PM_at

201955_at

2966372

2966373

2966374

2966375

2966376

2966377

2966378

2966379

2966380

2966381

2966382

2966383

2966384

2966385

2966386

2966389

2966392

2966393

2966394

2966395

2966396

2966397

2966398

2966399

2966400

2966401

2966403

2966407

2966408

2966409

2966411

2966412

2966413

2966414

2966415

2966416

2966417

2966419

2966420

2966421

2966422

2966423

39251_at

74582_s_at

8128429

81732_at

88037_at

892

A_23_P145397

A_33_P3357337

GE58064

GO:0000307

GO:0005515

GO:0005634

GO:0005654

GO:0006355

GO:0006357

GO:0016538

GO:0016592

GO:0042802

GO:0043226

GO:0045023

GO:0045746

GO:0045944

GO:0098772

GO:1990508

HMNXSV003019843

HMNXSV003020256

HMNXSV003020747

Hs.118442.0.A2_3p_at

Hs2.382730.1.S1_3p_at

ILMN_1676423

ILMN_1798705

ILMN_2409395

M74091_at

PH_hs_0025404

TC06001966.hg

Participates

as a component of

as an input of

Inferred To

ccnc [nucleoplasm] (Danio rerio)

ccnc [nucleoplasm] (Xenopus tropicalis)

Ccnc [nucleoplasm] (Mus musculus)

Ccnc [nucleoplasm] (Rattus norvegicus)

cycC [nucleoplasm] (Dictyostelium discoideum)

cic-1 [nucleoplasm] (Caenorhabditis elegans)

SSN8 [nucleoplasm] (Saccharomyces cerevisiae)

CycC [nucleoplasm] (Drosophila melanogaster)

srb11 [nucleoplasm] (Schizosaccharomyces pombe)

CCNC [nucleoplasm] (Bos taurus)

CCNC [nucleoplasm] (Canis familiaris)

CCNC [nucleoplasm] (Gallus gallus)

CCNC [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_005181.2, NP_001013417.1

OpenTargets

ENSG00000112237

ENSEMBL

ENST00000523985, ENST00000523799, ENSP00000430014, ENSP00000428982, ENST00000520429, ENSP00000430119

HPA

ENSG00000112237-CCNC

PRO

P24863

Pharos - Targets

P24863

GlyGen

P24863

PDB

4G6L, 5BNJ, 4F6U, 5ICP, 5I5Z, 6Y0A, 5HBE, 5HBJ, 4F6S, 5IDP, 4F70, 5HNB, 5HBH, 5XQX, 4F6W, 4F7J, 6QTJ, 5XS2, 5HVY, 4F7N, 5IDN, 4CRL, 5FGK, 6T41, 5CEI, 4F7S, 6TPA, 4F7L, 6QTG, 6R3S, 3RGF

Interactors (110)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49336 CDK8	1	CDK8 [nucleoplasm] (R-HSA-212440)	0.978	40
UniProt:Q9BWU1 CDK19	1	CDK19 [nucleoplasm] (R-HSA-556782)	0.848	8
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.782	7
UniProt:Q00526 CDK3			0.75	7
UniProt:Q93074 MED12	1	MED12 [nucleoplasm] (R-HSA-212343)	0.748	7
UniProt:Q9BTT4 MED10	1	MED10 [nucleoplasm] (R-HSA-212410)	0.725	5
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.718	6
UniProt:O60244 MED14	1	MED14 [nucleoplasm] (R-HSA-212441)	0.669	4
UniProt:Q96AQ6 PBIP1			0.666	5
UniProt:Q96PV4 PNMA5			0.666	4
UniProt:Q9HAN9 NMNAT1	1	NMNAT1 [nucleoplasm] (R-HSA-200484)	0.666	4
UniProt:P80188 LCN2	2	LCN2 [extracellular region] (R-HSA-5215934) LCN2 [specific granule lumen] (R-HSA-6799614)	0.666	4
UniProt:P17022 ZNF18	1	ZNF18 [nucleoplasm] (R-HSA-975005)	0.666	4
UniProt:O43186 CRX			0.666	4
UniProt:Q9HCM9 TRIM39	1	TRIM39 [cytosol] (R-HSA-5688971)	0.666	4
UniProt:Q9Y3C7 MED31	1	MED31 [nucleoplasm] (R-HSA-212429)	0.643	4
UniProt:Q9NX70 MED29	1	MED29 [nucleoplasm] (R-HSA-556821)	0.643	5
UniProt:A0JLT2 MED19	1	MED19 [nucleoplasm] (R-HSA-556819)	0.643	4
UniProt:Q13503 MED21	1	MED21 [nucleoplasm] (R-HSA-212456)	0.643	5
UniProt:Q9NPJ6 MED4	1	MED4 [nucleoplasm] (R-HSA-350263)	0.643	5
UniProt:Q9UHV7 MED13	1	MED13 [nucleoplasm] (R-HSA-212391)	0.641	5
UniProt:O75448 MED24	1	MED24 [nucleoplasm] (R-HSA-212331)	0.564	3
UniProt:P42772 CDKN2B	1	CDKN2B [cytosol] (R-HSA-182586)	0.556	3
UniProt:Q8TD31-3 CCHCR1			0.556	3
UniProt:Q3KQV3 ZNF792	1	ZNF792 [nucleoplasm] (R-HSA-3110242)	0.556	3
UniProt:A0A6Q8PF08 A0A6Q8PF08			0.556	3
UniProt:Q96JP2 MY15B			0.556	3
UniProt:Q92529 SHC3	2	SHC3 [cytosol] (R-HSA-3006448) p-Y-SHC3 [cytosol] (R-HSA-3009043)	0.556	3
UniProt:Q7Z3Y8 KRT27	1	KRT27 [cytosol] (R-HSA-6809587)	0.556	3
UniProt:P17568 NDUFB7	1	NDUFB7 [mitochondrial inner membrane] (R-HSA-59940)	0.556	3
UniProt:Q53GS7 GLE1	1	GLE1 [nucleoplasm] (R-HSA-8932905)	0.556	3
UniProt:Q8TF47 ZFP90	1	ZFP90 [nucleoplasm] (R-HSA-974988)	0.556	3
UniProt:Q6ZNG0 ZNF620	1	ZNF620 [nucleoplasm] (R-HSA-2127603)	0.556	3
UniProt:P55212 CASP6	5	CASP6(194-293) [cytosol] (R-HSA-266128) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:Q9BUY5 ZNF426	1	ZNF426 [nucleoplasm] (R-HSA-1247530)	0.556	3
UniProt:Q8TD55-2 PLEKHO2			0.556	3
UniProt:O75400-2 PRPF40A			0.556	3
UniProt:P78424 PO6F2			0.556	3
UniProt:Q8WWB3 DYDC1			0.556	3
UniProt:Q8N8B7-2 TCEANC			0.556	3
UniProt:O15409 FOXP2			0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:Q9NS73-5 MBIP			0.556	3
UniProt:P61024 CKS1B	1	CKS1B [nucleoplasm] (R-HSA-187533)	0.556	3
UniProt:O76011 KRT34	1	KRT34 [cytosol] (R-HSA-6809608)	0.556	3
UniProt:Q9UBL3 ASH2L	1	ASH2L [nucleoplasm] (R-HSA-1629834)	0.556	3
UniProt:Q9BX70 BTBD2			0.556	3
UniProt:I6L9F6 I6L9F6			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q9UHX1 PUF60	1	PUF60 [nucleoplasm] (R-HSA-8865910)	0.556	3
UniProt:P19012 KRT15	1	KRT15 [cytosol] (R-HSA-6809589)	0.556	3
UniProt:Q49A26 GLYR1			0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:Q99932-2 SPAG8			0.556	3
UniProt:Q9Y371 SHLB1			0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:Q3B820 F161A			0.556	3
UniProt:Q8TAE8 GADD45GIP1	1	GADD45GIP1 [mitochondrial matrix] (R-HSA-5368253)	0.556	3
UniProt:Q99633 PRPF18	1	PRPF18 [nucleoplasm] (R-HSA-5688093)	0.556	3
UniProt:O95983-2 MBD3			0.556	3
UniProt:P0C7X2 ZNF688	1	ZNF688 [nucleoplasm] (R-HSA-2248884)	0.556	3
UniProt:Q9BXU0 TEX12	1	TEX12 [nucleoplasm] (R-HSA-912441)	0.556	3
UniProt:P24863 CCNC	1	CCNC [nucleoplasm] (R-HSA-212418)	0.556	3
UniProt:Q9Y247 FA50B			0.556	3
UniProt:P08779 KRT16	1	KRT16 [cytosol] (R-HSA-201581)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	9
UniProt:Q86YD7 F90A1			0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:Q6PJQ5 FOXR2			0.556	3
UniProt:P40337-2 VHL			0.556	3
UniProt:P61086 UBE2K	2	UBE2K [cytosol] (R-HSA-934631) Ub-C92-UBE2K [cytosol] (R-HSA-8864200)	0.556	3
UniProt:O14880 MGST3	1	MGST3 [endoplasmic reticulum membrane] (R-HSA-176053)	0.556	3
UniProt:O60664 PLIN3	7	p-PLIN3 [lysosomal lumen] (R-HSA-9639396) p-PLIN3 [cytosol] (R-HSA-9613664) p-PLIN3 [lipid droplet] (R-HSA-9613539) PLIN3 [lipid droplet] (R-HSA-9613337) p-PLIN3 [late endosome lumen] (R-HSA-9639393) PLIN3 [cytosol] (R-HSA-6814628) PLIN3 [transport vesicle] (R-HSA-6813900)	0.556	3
UniProt:P40937 RFC5	1	RFC5 [nucleoplasm] (R-HSA-68427)	0.556	5
UniProt:Q92870-2 Q928702			0.556	3
UniProt:Q9UJW9 SRTD3			0.556	3
UniProt:Q96M91 CFA53			0.556	3
UniProt:Q9NP79 VTA1	1	VTA1 [cytosol] (R-HSA-917735)	0.556	3
UniProt:O75528 TADA3	1	TADA3 [nucleoplasm] (R-HSA-3322966)	0.556	3
UniProt:P50222 MEOX2			0.556	3
UniProt:Q96IZ5 RBM41			0.556	3
UniProt:Q6QNY1 BL1S2			0.556	3
UniProt:Q96N21 AP4AT			0.556	3
UniProt:P15927 RPA2	2	RPA2 [nucleoplasm] (R-HSA-68457) p-S33-RPA2 [nucleoplasm] (R-HSA-5685148)	0.556	3
UniProt:Q04864-2 REL			0.556	3
UniProt:A1A4E9 A1A4E9			0.556	3
UniProt:Q8N443 RIBC1			0.556	5
UniProt:Q6ZRS2-3 SRCAP			0.556	3
UniProt:Q9ULR0 ISY1	1	ISY1 [nucleoplasm] (R-HSA-6781963)	0.556	3
UniProt:Q9Y228 T3JAM			0.556	3
UniProt:Q9BVN2 RUSC1			0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:Q96F24 NRBF2			0.556	3
UniProt:Q02548 PAX5	1	PAX5 [nucleoplasm] (R-HSA-158583)	0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:O75586 MED6	1	MED6 [nucleoplasm] (R-HSA-212359)	0.527	3
UniProt:Q71F56 MED13L	1	MED13L [nucleoplasm] (R-HSA-556797)	0.527	3
UniProt:Q9P086 MED11	1	MED11 [nucleoplasm] (R-HSA-556808)	0.527	3
UniProt:O43513 MED7	1	MED7 [nucleoplasm] (R-HSA-212430)	0.527	3
UniProt:Q71SY5 MED25	1	MED25 [nucleoplasm] (R-HSA-212414)	0.527	3
UniProt:Q9NWA0 MED9	1	MED9 [nucleoplasm] (R-HSA-556804)	0.527	3
UniProt:Q9H204 MED28	1	MED28 [nucleoplasm] (R-HSA-6804546)	0.527	3
UniProt:Q15528 MED22	1	MED22 [nucleoplasm] (R-HSA-556779)	0.527	3
UniProt:Q15648 MED1	1	MED1 [nucleoplasm] (R-HSA-212445)	0.527	3
UniProt:Q96HR3 MED30	1	MED30 [nucleoplasm] (R-HSA-212398)	0.527	2
UniProt:Q9H944 MED20	1	MED20 [nucleoplasm] (R-HSA-212428)	0.527	3
UniProt:Q9BUE0 MED18	1	MED18 [nucleoplasm] (R-HSA-556826)	0.527	4
UniProt:Q6P2C8 MED27	1	MED27 [nucleoplasm] (R-HSA-556761)	0.527	3
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.524	4
UniProt:Q9ULK4 MED23	1	MED23 [nucleoplasm] (R-HSA-556823)	0.483	3

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