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MED21 [nucleoplasm]
Stable Identifier
R-HSA-212456
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Adipogenesis (Homo sapiens)
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
Expression of ANGPTL4 (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED21 [nucleoplasm] (Homo sapiens)
Expression of Adiponectin (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED21 [nucleoplasm] (Homo sapiens)
Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED21 [nucleoplasm] (Homo sapiens)
Expression of CEBPA (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED21 [nucleoplasm] (Homo sapiens)
Expression of FABP4 (aP2) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED21 [nucleoplasm] (Homo sapiens)
Expression of Leptin (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED21 [nucleoplasm] (Homo sapiens)
Expression of Lipoprotein lipase (LPL) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED21 [nucleoplasm] (Homo sapiens)
Expression of Perilipin (PLIN) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED21 [nucleoplasm] (Homo sapiens)
Expression of Phosphoenolpyruvate carboxykinase 1 (PEPCK-C) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED21 [nucleoplasm] (Homo sapiens)
PPARG:RXRA heterodimer binds to fatty acid-like ligands (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED21 [nucleoplasm] (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED21 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
RSV-host interactions (Homo sapiens)
NS1 (1C) binds to Mediator complex (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED21 [nucleoplasm] (Homo sapiens)
Mediator:NS1 [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED21 [nucleoplasm] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Regulation of lipid metabolism by PPARalpha (Homo sapiens)
PPARA activates gene expression (Homo sapiens)
Expression of ANGPTL4 (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED21 [nucleoplasm] (Homo sapiens)
Expression of CD36 (platelet glycoprotein IV, FAT) (Homo sapiens)
PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm] (Homo sapiens)
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
MED21 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13503 MED21
Gene Names
MED21, SRB7, SURB7
Chain
chain:1-144
Reference Genes
BioGPS Gene:9412 MED21
COSMIC (genes):MED21 MED21
CTD Gene:9412 MED21
dbSNP Gene:9412 MED21
ENSEMBL:ENSG00000152944 MED21
HGNC:11473 MED21
KEGG:hsa:9412 MED21
Monarch:9412 MED21
NCBI Gene:9412 MED21
OMIM:603800 MED21
UCSC:Q13503 MED21
Reference Transcript
RefSeq:NM_004264.4 MED21
Other Identifiers
11719677_a_at
11719678_a_at
11758234_s_at
11758813_x_at
16749382
209362_PM_at
209362_at
209363_PM_s_at
209363_s_at
3409007
3409008
3409009
3409010
3409012
3409013
3409014
3409015
3409016
3409017
3409018
3409019
3409020
3409021
3409026
3409028
3409029
3409030
3409031
3409033
34356_at
34357_g_at
72986_at
7954503
9412
A_14_P201329
A_23_P2262
A_33_P3400547
GE498135
GE61821
GE880972
GO:0000151
GO:0001824
GO:0003712
GO:0003713
GO:0003824
GO:0003899
GO:0005515
GO:0005634
GO:0005654
GO:0006355
GO:0006357
GO:0016567
GO:0016592
GO:0016740
GO:0032968
GO:0035019
GO:0043226
GO:0045944
GO:0048856
GO:0051123
GO:0060090
GO:0060261
GO:0061630
GO:0065003
GO:0070847
GO:0140096
GO:0140098
GO:0140110
HMNXSV003001140
HMNXSV003010953
Hs.286145.0.A2_3p_at
ILMN_1773886
PH_hs_0014800
PH_hs_0019734
TC12000262.hg
U52960_at
g1197662_3p_a_at
Participates
as a component of
Mediator Complex (consensus) [nucleoplasm] (Homo sapiens)
Cross References
RefSeq
NP_004255.2
OpenTargets
ENSG00000152944
ENSEMBL
ENSP00000282892
,
ENST00000282892
HPA
ENSG00000152944-MED21
PRO
Q13503
Pharos - Targets
Q13503
PDB
8GXS
,
8GXQ
,
7ENJ
,
7EMF
,
7NVR
,
7ENA
,
7LBM
,
7ENC
Interactors (36)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BTT4 MED10
1
MED10 [nucleoplasm]
(R-HSA-212410)
0.901
11
UniProt:P49336 CDK8
1
CDK8 [nucleoplasm]
(R-HSA-212440)
0.886
12
UniProt:O95402 MED26
1
MED26 [nucleoplasm]
(R-HSA-556783)
0.877
12
UniProt:Q9NPJ6 MED4
1
MED4 [nucleoplasm]
(R-HSA-350263)
0.859
11
UniProt:O43513 MED7
1
MED7 [nucleoplasm]
(R-HSA-212430)
0.802
7
UniProt:Q15648 MED1
1
MED1 [nucleoplasm]
(R-HSA-212445)
0.802
7
UniProt:Q9H944 MED20
1
MED20 [nucleoplasm]
(R-HSA-212428)
0.788
7
UniProt:Q9Y3C7 MED31
1
MED31 [nucleoplasm]
(R-HSA-212429)
0.725
7
UniProt:Q9UHV7 MED13
1
MED13 [nucleoplasm]
(R-HSA-212391)
0.725
6
UniProt:O60244 MED14
1
MED14 [nucleoplasm]
(R-HSA-212441)
0.725
7
UniProt:O75448 MED24
1
MED24 [nucleoplasm]
(R-HSA-212331)
0.725
6
UniProt:O75586 MED6
1
MED6 [nucleoplasm]
(R-HSA-212359)
0.725
6
UniProt:Q93074 MED12
1
MED12 [nucleoplasm]
(R-HSA-212343)
0.725
6
UniProt:Q9NVC6 MED17
1
MED17 [nucleoplasm]
(R-HSA-212401)
0.725
6
UniProt:Q96HR3 MED30
1
MED30 [nucleoplasm]
(R-HSA-212398)
0.725
6
UniProt:A1L4H1 SSC5D
1
SSC5D [extracellular region]
(R-HSA-8878615)
0.718
6
UniProt:Q9ULK4 MED23
1
MED23 [nucleoplasm]
(R-HSA-556823)
0.706
6
UniProt:Q6P2C8 MED27
1
MED27 [nucleoplasm]
(R-HSA-556761)
0.643
6
UniProt:Q9Y2X0 MED16
1
MED16 [nucleoplasm]
(R-HSA-556802)
0.643
5
UniProt:P24863 CCNC
1
CCNC [nucleoplasm]
(R-HSA-212418)
0.643
5
UniProt:Q96G25 MED8
1
MED8 [nucleoplasm]
(R-HSA-556784)
0.643
5
UniProt:O14964 HGS
2
HGS [cytosol]
(R-HSA-182954)
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
0.556
3
UniProt:Q6ZMU5 TRIM72
1
TRIM72 [cytoplasmic vesicle membrane]
(R-HSA-5263653)
0.556
3
UniProt:Q9UL45 BLOC1S6
1
BLOC1S6 [cytosol]
(R-HSA-429816)
0.556
3
UniProt:O75911 DHRS3
2
DHRS3 [endoplasmic reticulum membrane]
(R-HSA-5419172)
DHRS3 [photoreceptor outer segment membrane]
(R-HSA-2980986)
0.527
3
UniProt:Q07065 CKAP4
7
CKAP4 [endoplasmic reticulum lumen]
(R-HSA-8956737)
p-CKAP4 [endoplasmic reticulum lumen]
(R-HSA-8956926)
CKAP4 [azurophil granule membrane]
(R-HSA-6799559)
CKAP4 [plasma membrane]
(R-HSA-5686306)
CKAP4 [specific granule membrane]
(R-HSA-6799552)
PALM-C100-CKAP4 [plasma membrane]
(R-HSA-5686280)
PALM-C100-CKAP4 [lamellar body]
(R-HSA-5686285)
0.527
2
UniProt:P19388 POLR2E
2
POLR2E [cytosol]
(R-HSA-1964438)
POLR2E [nucleoplasm]
(R-HSA-83713)
0.527
2
UniProt:Q7L9B9 EEPD1
1
EEPD1 [plasma membrane]
(R-HSA-9035163)
0.527
2
UniProt:P17677 GAP43
2
GAP43 [plasma membrane]
(R-HSA-452888)
PALM-C3,4-GAP43 [plasma membrane]
(R-HSA-8933482)
0.527
2
UniProt:Q15836 VAMP3
6
VAMP3 [recycling endosome membrane]
(R-HSA-2029063)
VAMP3 [phagocytic vesicle membrane]
(R-HSA-2029013)
VAMP3 [plasma membrane]
(R-HSA-8867599)
VAMP3 [trans-Golgi network membrane]
(R-HSA-6814624)
VAMP3 [transport vesicle]
(R-HSA-6814625)
VAMP3 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869130)
0.527
2
UniProt:O95470 SGPL1
1
PXLP-SGPL1 [endoplasmic reticulum membrane]
(R-HSA-428661)
0.527
2
UniProt:Q9BV40 VAMP8
11
VAMP8 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869137)
VAMP8 [secretory granule membrane]
(R-HSA-376368)
VAMP8 [cytoplasmic vesicle membrane]
(R-HSA-376373)
VAMP8 [Golgi membrane]
(R-HSA-266201)
VAMP8 [lysosomal membrane]
(R-HSA-432710)
VAMP8 [phagocytic vesicle membrane]
(R-HSA-8863896)
VAMP8 [recycling endosome membrane]
(R-HSA-8863891)
VAMP8 [tertiary granule membrane]
(R-HSA-6801024)
VAMP8 [specific granule membrane]
(R-HSA-6799707)
VAMP8 [plasma membrane]
(R-HSA-376365)
VAMP8 [azurophil granule membrane]
(R-HSA-6799703)
0.527
2
UniProt:Q71SY5 MED25
1
MED25 [nucleoplasm]
(R-HSA-212414)
0.527
4
UniProt:Q96RN5 MED15
1
MED15 [nucleoplasm]
(R-HSA-556827)
0.527
4
UniProt:P07947 YES1
2
MyrG-p-Y426-YES1 [plasma membrane]
(R-HSA-1810411)
YES1 [cytosol]
(R-HSA-373640)
0.527
2
UniProt:O15392 BIRC5
3
BIRC5 [cytosol]
(R-HSA-50851)
BIRC5 [nucleoplasm]
(R-HSA-4655344)
ub-BIRC5 [cytosol]
(R-HSA-8955933)
0.527
2
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